Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy DOI
Milad Ashrafizadeh, Kiavash Hushmandi, Sepideh Mirzaei

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

Smart Nano‐PROTACs Reprogram Tumor Microenvironment for Activatable Photo‐metabolic Cancer Immunotherapy DOI
Chi Zhang, Shasha He,

Ziling Zeng

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(8)

Published: Dec. 20, 2021

Protease inhibitors can modulate intratumoral metabolic processes to reprogram the immunosuppressive tumor microenvironment (TME), which however suffer from limited efficacy and off-targeted side effects. We report smart nano-proteolysis targeting chimeras (nano-PROTACs) with phototherapeutic ablation cancer-specific protein degradation TME for photo-metabolic cancer immunotherapy. This nano-PROTAC has a semiconducting polymer backbone linked cyclooxygenase 1/2 (COX-1/2)-targeting PROTAC peptide (CPP) via cathepsin B (CatB)-cleavable segment. CPP be activated by tumor-overexpressed CatB induce of COX-1/2 ubiquitin-proteasome system. The persistent depletes their metabolite prostaglandin E2 is responsible activation immune suppressor cells. Such strategy synergized phototherapy specifically reprograms reinvigorates antitumor immunity.

Language: Английский

Citations

100
Crosstalk between miRNA and PI3K/AKT/mTOR signaling pathway in cancer DOI

Maryam Akbarzadeh,

Ainaz Mihanfar,

Shabnam Akbarzadeh

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 285, P. 119984 - 119984

Published: Sept. 27, 2021

Language: Английский

Citations

88
RNA-based therapies: A cog in the wheel of lung cancer defense DOI Creative Commons
Parvez Κhan, Jawed A. Siddiqui, Imayavaramban Lakshmanan

et al.

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: March 19, 2021

Abstract Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small cell lung (NSCLC) and small (SCLC), remains the leading cause death worldwide. Despite recent advances in therapies, overall 5-year survival rate LC less than 20%. The efficacy current therapeutic approaches compromised by inherent or acquired drug-resistance severe off-target effects. Therefore, identification development innovative effective are critically desired for LC. RNA-mediated gene inhibition technologies was turning point field RNA biology. critical regulatory role different RNAs multiple pathways makes them rich source targets tools developing anticancer therapies. antisense sequences, short interfering (siRNAs), microRNAs (miRNAs miRs), anti-miRs, mRNA-based platforms holds great promise preclinical early clinical evaluation against In last decade, RNA-based therapies have substantially expanded tested trials malignancies, including This article describes understanding various aspects therapeutics, modern platforms, modifications, combinations with chemo-/immunotherapies that translational potential

Language: Английский

Citations

78
A bibliometric analysis of PROTAC from 2001 to 2021 DOI
Deping Li,

Dongmin Yu,

Yan Li

et al.

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 244, P. 114838 - 114838

Published: Oct. 14, 2022

Language: Английский

Citations

66
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy DOI
Milad Ashrafizadeh, Kiavash Hushmandi, Sepideh Mirzaei

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

Citations

63