Journal of Hazardous Materials Advances,
Journal Year:
2023,
Volume and Issue:
11, P. 100355 - 100355
Published: Aug. 1, 2023
Regulations
for
contaminants
are
primarily
based
on
isolated
exposures
to
an
individual
toxicant.
This
practice
does
not
account
interactions
that
may
happen
between
toxicants.
The
assessment
of
chemical
mixtures
ought
be
routinely
studied
better
understand
the
risks
human
health,
yet
no
standard
protocol
exists.
study
provides
a
framework
focusing
complex
toxicants
and
how
can
affect
potential
regulatory
shift.
work
evaluates
binary
environmental
contaminants,
lead(II)
acetate,
copper(II)
nitrate,
glyphosate,
against
neuronal
brain
cell
model
(SH-SY5Y)
by
comparing
concentration
addition
(CA)
experimental
cytotoxicity
values.
Binary
mixture
effects
were
identified
interpreted
using
interaction
index
isobologram.
Isobolograms
developed
visualize
comparative
data.
Against
model,
EC50
values
composed
copper-lead
copper-glyphosate
showed
antagonistic
responses
with
indices
greater
than
one.
lead-glyphosate
produced
additive
within
95%
confidence
interval
These
results,
along
mechanism
elucidations,
illustrate
complexity
toxicology
need
further
studies
emphasizing
comparisons
prediction
modeling
results.
Journal of Environmental Exposure Assessment,
Journal Year:
2025,
Volume and Issue:
4(1)
Published: Feb. 19, 2025
This
perspective
presents
first-hand
research
insights
into
the
pervasive
environmental
distribution
of
neonicotinoid
insecticides
(NEOs)
and
their
consequent
human
exposure.
Our
findings
reveal
widespread
NEO
detection
across
biological
matrices,
indicating
potential
health
risks
highlighting
critical
gaps
in
current
risk
assessment
paradigms.
We
identify
an
urgent
need
for
longitudinal
epidemiological
studies,
particularly
focusing
on
vulnerable
populations,
to
comprehensively
assess
NEO-related
outcomes.
These
scientific
should
inform
evidence-based
policy
reforms
management
strategies
effectively
protect
both
public
integrity.
Journal of Hazardous Materials Advances,
Journal Year:
2023,
Volume and Issue:
11, P. 100355 - 100355
Published: Aug. 1, 2023
Regulations
for
contaminants
are
primarily
based
on
isolated
exposures
to
an
individual
toxicant.
This
practice
does
not
account
interactions
that
may
happen
between
toxicants.
The
assessment
of
chemical
mixtures
ought
be
routinely
studied
better
understand
the
risks
human
health,
yet
no
standard
protocol
exists.
study
provides
a
framework
focusing
complex
toxicants
and
how
can
affect
potential
regulatory
shift.
work
evaluates
binary
environmental
contaminants,
lead(II)
acetate,
copper(II)
nitrate,
glyphosate,
against
neuronal
brain
cell
model
(SH-SY5Y)
by
comparing
concentration
addition
(CA)
experimental
cytotoxicity
values.
Binary
mixture
effects
were
identified
interpreted
using
interaction
index
isobologram.
Isobolograms
developed
visualize
comparative
data.
Against
model,
EC50
values
composed
copper-lead
copper-glyphosate
showed
antagonistic
responses
with
indices
greater
than
one.
lead-glyphosate
produced
additive
within
95%
confidence
interval
These
results,
along
mechanism
elucidations,
illustrate
complexity
toxicology
need
further
studies
emphasizing
comparisons
prediction
modeling
results.
