Adipogenic and osteogenic effects of OBS and synergistic action with PFOS via PPARγ–RXRα heterodimers DOI Creative Commons
Hui Qin,

Yueming Lang,

Yiteng Wang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 183, P. 108354 - 108354

Published: Nov. 25, 2023

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is a novel alternative to perfluorooctane sulfonate (PFOS), with environmental health risks largely unknown. The present study aims unravel the adipogenesis effects and underlying molecular initiating events of OBS, which are crucial for understanding predicting its adverse outcome. In undifferentiated human mesenchymal stem cells (hMSCs), exposure 1-100 nM OBS 7 days stimulated reactive oxygen species production. subsequent multipotent differentiation, hMSCs favored repressed osteogenesis. point departure (PoD) cellular responses was 38.85 nM, higher than PFOS (0.39 nM). Notably, OBS/PFOS co-exposure inhibited osteogenesis synergistically promoted adipogenesis. Consistently, expression adipogenic marker genes up-regulated, while that osteogenic down-regulated. decreased adiponectin elevated tumour necrosis factor α (TNFα) secretion were observed in differentiated exposed mixture PFOS. co-treatment peroxisome proliferator-activated receptor γ (PPARγ) antagonist alleviated combination OBS. Moreover, induced PPARγ activation reporter gene assays, increased formation - retinoid X (RXRα) heterodimers measured by co-immunoprecipitation assays. Molecular docking showed interaction energy (-20.7 kcal/mol) intact PPARγ-RXRα complex lower (-25.9 kcal/mol). Overall, single exhibited potency inducing but comparable repressing osteogenesis, whereas increases heterodimers, resulting synergistic PPARγ, ultimately enhancing at expense differentiation. results indicate potential obesity bone density caused PFOS, as well other perfluorinated alkylated substances mixtures.

Language: Английский

Association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort DOI

Xin-xin Gao,

Qian-lin Zuo,

Xihang Fu

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116812 - 116812

Published: Aug. 1, 2023

Language: Английский

Citations

8
Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort DOI Creative Commons
Carolyn Waugh Kinkade, Zorimar Rivera‐Núñez, Sally W. Thurston

et al.

Environmental Health, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 2, 2023

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals found in drinking water consumer products, resulting ubiquitous human exposure. PFAS have been linked to endocrine disruption altered weight gain across the lifespan. A limited inconsistent body of research suggests may impact gestational (GWG) postpartum mass index (BMI), which important predictors overall infant maternal health, respectively. Methods In Understanding Pregnancy Signals Infant Development (UPSIDE/UPSIDE-MOMs) study ( n = 243; Rochester, NY), we examined second trimester serum (PFOS: perfluorooctanesulfonic acid, PFOA: perfluorooctanoic PFNA: perfluorononanoic PFHxS: perfluorohexanesulfonic PFDA: perfluorodecanoic acid) relation GWG (kg, weekly rate gain) postpartum, retention (PPWR (kg) total fat percentage (measured by bioelectrical impedance)). We fit multivariable linear regression models examining these outcomes log-transformed whole cohort as well stratified pre-pregnancy BMI (< 25 vs. > kg/m 2 ), adjusting for demographics lifestyle factors. used weighted quantile sum find combined influence 5 on GWG, PPWR, percentage. Results PFOA PFHxS were inversely associated with (PFOA: ß -1.54 kg, 95%CI: -2.79, -0.30; -0.05 kg/week, -0.09, -0.01; -1.59 -3.39, 0.21; -0.11, 0.01) PPWR at 6 12 months (PFOA months: -2.39 -4.17, -0.61; -4.02 -6.58, -1.46; -2.94 -5.52, -0.35; -5.13 -8.34, -1.93). was additionally lower (ß -1.75, -3.17, -0.32; -1.64, -3.43, 0.16, respectively) stronger associations observed participants higher BMI. The mixture -2.030, -3.486, -0.573) amongst all participants. Conclusion PFAS, particular PFHxS, pregnancy patterns adiposity potential implications fetal development long-term cardiometabolic health.

Language: Английский

Citations

7
The Association between Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Respiratory Tract Infections in Preschool Children: A Wuhan Cohort Study DOI Creative Commons
Haiyun Huang, Xiaojun Li,

Yican Deng

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(11), P. 897 - 897

Published: Nov. 2, 2023

This study investigates the association between prenatal exposure to per- and polyfluoroalkyl substances (PFASs) incidence frequency of respiratory tract infections (RTIs) in preschool children. We selected 527 mother–infant pairs from Wuhan Healthy Baby Cohort (WHBC), China. Ten PFASs were measured umbilical cord serum, we collected data on common RTIs children aged 4 years through a questionnaire. Associations single with analyzed via Logistic regression Poisson regression, while collective effect was assessed by weighted quantile sum (WQS) regression. Furthermore, stratified interaction analyses performed evaluate if there sex-specific associations. found positive correlation perfluorododecanoic acid (PFDoDA) tonsillitis, several also showing associations its frequency. Moreover, perfluorotridecanoic (PFTrDA) showed link cold. The results WQS revealed that after adjusting for other covariates, mixture cold, episodes. In particular, perfluoroundecanoic (PFUnDA), PFDoDA, PFTrDA, perfluorodecanoic (PFDA) 8:2 chlorinated polyfluorinated ether sulfonic (8:2 Cl-PFESA) had most significant impact this combined effect. suggest both mixed exposures may cause However, no statistically different sex.

Language: Английский

Citations

7
Associations between maternal exposure to perfluoroalkylated substances (PFASs) and infant birth weight: a meta-analysis DOI

Linchen Lan,

Hongcheng Wei, Danrong Chen

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(38), P. 89805 - 89822

Published: July 17, 2023

Language: Английский

Citations

6
Adipogenic and osteogenic effects of OBS and synergistic action with PFOS via PPARγ–RXRα heterodimers DOI Creative Commons
Hui Qin,

Yueming Lang,

Yiteng Wang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 183, P. 108354 - 108354

Published: Nov. 25, 2023

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is a novel alternative to perfluorooctane sulfonate (PFOS), with environmental health risks largely unknown. The present study aims unravel the adipogenesis effects and underlying molecular initiating events of OBS, which are crucial for understanding predicting its adverse outcome. In undifferentiated human mesenchymal stem cells (hMSCs), exposure 1-100 nM OBS 7 days stimulated reactive oxygen species production. subsequent multipotent differentiation, hMSCs favored repressed osteogenesis. point departure (PoD) cellular responses was 38.85 nM, higher than PFOS (0.39 nM). Notably, OBS/PFOS co-exposure inhibited osteogenesis synergistically promoted adipogenesis. Consistently, expression adipogenic marker genes up-regulated, while that osteogenic down-regulated. decreased adiponectin elevated tumour necrosis factor α (TNFα) secretion were observed in differentiated exposed mixture PFOS. co-treatment peroxisome proliferator-activated receptor γ (PPARγ) antagonist alleviated combination OBS. Moreover, induced PPARγ activation reporter gene assays, increased formation - retinoid X (RXRα) heterodimers measured by co-immunoprecipitation assays. Molecular docking showed interaction energy (-20.7 kcal/mol) intact PPARγ-RXRα complex lower (-25.9 kcal/mol). Overall, single exhibited potency inducing but comparable repressing osteogenesis, whereas increases heterodimers, resulting synergistic PPARγ, ultimately enhancing at expense differentiation. results indicate potential obesity bone density caused PFOS, as well other perfluorinated alkylated substances mixtures.

Language: Английский

Citations

4