Bioaccumulation and Potential Endocrine Disruption Risk of Legacy and Emerging Organophosphate Esters in Cetaceans from the Northern South China Sea

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Despite the increasing health risks shown by continuous detection of organophosphate esters (OPEs) in biota recent years, information on occurrence and potential OPEs marine mammals remains limited. This study conducted first investigation into body burdens 10 traditional (tOPEs) five emerging (eOPEs) cetacean species (n = 84) from northern South China Sea (NSCS) during 2005–2021. All OPEs, except for 2-ethylhexyl diphenyl phosphate (EHDPHP), were detected these cetaceans, indicating their widespread NSCS. Although levels ∑10tOPEs humpback dolphins remained stable 2005 to 2021, concentrations ∑5eOPEs showed a significant increase, suggesting growing demand new-generation China. Dolphins proximity urban regions generally exhibited higher OPE than those rural areas, mirroring environmental trends occurring this area. congeners, EHDPHP, maternal transfer ratio >1, that dolphin placenta may not be an efficient barrier OPEs. The observed correlations between hormones (triiodothyronine, thyroxine, testosterone) indicated exposures might have endocrine disruption effects population.

Language: Английский

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Perfluorohexanesulfonic Acid (PFHxS) Impairs Lipid Homeostasis in Zebrafish Larvae through Activation of PPARα

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(37), P. 16258 - 16268

Published: Aug. 15, 2024

Perfluorohexanesulfonic acid (PFHxS), an emerging short-chain per- and polyfluoroalkyl substance, has been frequently detected in aquatic environments. Adverse outcome pathway studies have shown that perfluorinated compounds impair lipid homeostasis through peroxisome proliferator activated receptors (PPARs). However, many of these were performed at high concentrations may thus be a result overt toxicity. To better characterize the molecular key events PFHxS to biota, early life-stage zebrafish (Danio rerio) exposed environment (0.01, 0.1, 1, 10 μg/L). Lipidomic transcriptomic evaluations integrated predict potential targets. significantly impaired by dysregulation glycerophospholipids, fatty acyls, glycerolipids, sphingolipids, prenol lipids, sterol lipids. Informatic analyses lipidome transcriptome indicated alterations PPAR signaling pathway, with downstream changes retinol, linoleic acid, glycerophospholipid metabolism. assess role PPARs, binding PPARs was predicted animals coexposed antagonist (GW6471). Molecular simulation had 27.1% affinity than oleic endogenous agonist PPARα. Antagonist coexposures rescued glycerophosphocholine altered PFHxS. These data indicate PPARα activation important initiating event for

Language: Английский

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Environmental Chemical-Induced Cardiometabolic Disorders: Combined Epidemiological and Experimental Evidence

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Screening environmental pollutants that are harmful to the cardiometabolic status and understanding their key toxic pathways crucial for effective clinical intervention. Based on exposure data of 46 chemicals in a nationally representative 13,286 people, logistic regression mixture modeling were used preliminarily identify with significant impacts 12 indicators disorders. A total 15 found be associated integrated latent class, among which four (perfluorononanoic acid [PFNA], perfluorooctanoic [PFOA], thiocyanate, thallium) also contributed significantly effect. We constructed adverse outcome (AOPs) nine toxicants both models individual each disorder. Notably, fluoroalkyl substances affect multiple aspects hyperlipidemia by activating PPARα. performed molecular docking vitro experiments verify supplement toxicological mechanism PFNA. Through binding PPARα, PFNA increased levels downstream molecules including CD36 (fatty transfer), ACSL1 activation), CPT1a (intracellular transfer β-oxidation) ultimately promoted accumulation triglycerides lipid droplets HepG2 cells. These markers, together events other metabolic phenotypes, may potential targets scientific research or treatment.

Language: Английский

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Impact of Persistent Endocrine-Disrupting Chemicals on Human Nuclear Receptors: Insights from In Silico and Experimental Characterization

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2879 - 2879

Published: March 21, 2025

Endocrine-disrupting chemicals (EDCs) are notable for their persistence, bioaccumulation, and associations with cancer. Human nuclear receptors (hNRs) primary targets disrupted by these persistent EDCs, resulting in alterations to xenobiotic metabolism, lipid homeostasis, endocrine function, which can lead carcinogenic effects. Despite hazardous effects, comprehensive studies on EDC interactions impacts hNRs remain limited. Here, we profiled the of including PFAS, plastic additives, bisphenols, polybrominated diphenyl ethers, phthalates, key such as PXR, CAR, PPARα, PPARγ, PPARδ, AR, RORγt. Through controlled molecular docking simulations, observed strong binding EDCs receptors. Further analysis showed that exhibit activity towards preferentially interacting hydrophobic amino acids, namely leucine, isoleucine, methionine, phenylalanine. PFAS demonstrated highest affinity, characterized a combination complementary from fluorinated carbon chains polar functional groups (e.g., carboxylate, sulfonate) across all Distinct polycyclic trends, contributing NR binding, were evident non-PFAS nonplastic EDCs. The hNR assay HepG2 cells revealed agonistic effects dicyclohexyl phthalate (DCHP) di-2-ethylhexyl (DEHP) most receptors, except PPARα. transcription factor pathway increased gene expression VDRE suggesting potential chronic metabolism calcium homeostasis. Overall, our findings demonstrate need further research into disruption

Language: Английский

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Phenyltins May Pose a Higher Health Risk to Indo-Pacific Finless Porpoises Than Butyltins

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138190 - 138190

Published: April 1, 2025

Language: Английский

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Accumulation features and temporal trends (2002–2015) for legacy and emerging per- and polyfluoroalkyl substances (PFASs) in finless porpoises bycaught off Korean coasts

Environmental Pollution, Journal Year: 2024, Volume and Issue: 349, P. 123925 - 123925

Published: April 7, 2024

Language: Английский

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Binding of Per- and Polyfluoroalkyl Substances (PFAS) to the PPARγ/RXRα–DNA Complex

Journal of Chemical Information and Modeling, Journal Year: 2023, Volume and Issue: 63(23), P. 7423 - 7443

Published: Nov. 22, 2023

Nuclear receptors are the fundamental building blocks of gene expression regulation and focus many drug targets. While binding to DNA, nuclear act as transcription factors, governing a multitude functions in human body. Peroxisome proliferator-activator receptor γ (PPARγ) retinoid X α (RXRα) form heterodimers with unique properties have primordial role insulin sensitization. This PPARγ/RXRα heterodimer has been shown be impacted by per- polyfluoroalkyl substances (PFAS) linked variety significant health conditions humans. Herein, selection most common PFAS (legacy emerging) was studied utilizing molecular dynamics simulations for PPARγ/RXRα. The local global structural effects on known ligand pockets PPARγ RXRα well DNA domain (DBD) were inspected. free energies predicted computationally compared between different pockets. In addition, two electronic structure approaches utilized model interaction within domain, density functional theory (DFT) domain-based pair natural orbital coupled cluster perturbative triples (DLPNO–CCSD(T)) approaches, implicit solvation. Residue decomposition hydrogen-bonding analysis also performed, detailing prominent residues recognition. l-carnitine is explored potential vivo remediation strategy heterodimer. this work, it found that can bind agonists all investigated For first time literature, postulated nonspecific manner. shows promise replacing smaller from pocket.

Language: Английский

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Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps

Journal of Immunotoxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 7, 2024

Per- and polyfluoroalkyl substances (PFASs) are a large class of compounds used in variety processes consumer products. Their unique chemical properties make them ubiquitous persistent environmental contaminants while also making economically viable socially convenient. To date, several reviews have been published to synthesize information regarding the immunotoxic effects PFASs on adaptive immune system. However, these often do not include data impact innate immunity. Here, current literature is reviewed identify incorporate immunity humans, experimental models, wildlife. Known mechanisms by which modulate function reviewed, including disruption cell signaling, metabolism, tissue-level effects. For where available, results equivocal, raising additional questions about common or pathways toxicity, but highlighting that system within species can be perturbed exposure PFASs. Recommendations provided for future research inform hazard identification, risk assessment, management practices protect systems exposed organisms as well health.

Language: Английский

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Enhanced coagulation coupled with cyclic IX adsorption–ARP regeneration for removal of PFOA in drinking water treatment

Water Environment Research, Journal Year: 2023, Volume and Issue: 95(10)

Published: Sept. 23, 2023

Abstract Laboratory investigations were conducted to demonstrate a potentially transformative, cost‐efficient per‐ and polyfluoroalkyl substances (PFAS) treatment approach, consisting of enhanced coagulation repeated ion exchange (IX)–advanced reduction process (ARP) for concurrent PFAS removal IX resin regeneration. Enhanced alum at the optimal conditions (pH 6.0, 60 mg/L alum) could preferentially remove high molecular‐weight, hydrophobic natural organic matter (NOM) from 5.0‐ ~1.2‐mg/L DOC in simulated water. This facilitated subsequent adsorption perfluorooctanoic acid (PFOA, model this study) (20 μg/L) using IRA67 by minimizing competition NOM functional sites on resin. The PFOA/NOM‐laden was then treated ARP, generating hydrated electrons (e aq − ) that effectively degraded PFOA. combined IX‐ARP regeneration applied over six cycles treat PFOA pre‐coagulated water, nearly doubling compared with control group without ARP study underscores potential coupled cyclic as promising, cost‐effective solution addressing pollution Practitioner Points can substantially mitigate favor following Cyclic adsorption–ARP offers an effective, economical degrade during

Language: Английский

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Persistent metabolic toxicities following developmental exposure to hexafluoropropylene oxide trimer acid (HFPO-TA): Roles of peroxisome proliferator activated receptor gamma

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134337 - 134337

Published: April 17, 2024

Language: Английский

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