Comprehensive Characterization of Organic Light-Emitting Materials in Breast Milk by Target and Suspect Screening DOI
Shuping Zheng, Jingsheng Wang, Kai Luo

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(11), P. 5103 - 5116

Published: March 6, 2024

Organic light-emitting materials (OLEMs) are emerging contaminants in the environment and have been detected various samples. However, limited information is available regarding their contamination within human body. Here, we developed a novel QuEChERS (quick, easy, cheap, effective, rugged, safe) method coupled with triple quadrupole/high-resolution mass spectrometry to determine OLEMs breast milk samples, employing both target suspect screening strategies. Our analysis uncovered presence of seven out 39 targeted comprising five liquid crystal monomers two commonly used organic diode displays. The cumulative concentrations each sample ranged from ND 1.67 × 103 ng/g lipid weight, mean median concentration 78.76 0.71 respectively, which were higher compared that typical pollutants such as polychlorinated biphenyls polybrominated diphenyl ethers. We calculated estimated daily intake (EDI) rates for infants aged 0–12 months, EDI during lactation range 30.37 54.89 ng/kg bw/day. Employing approach, additionally identified 66 potential OLEMs, them, cholesteryl hydrogen phthalate benzoate, further confirmed using pure reference standards. These substances belong cholesteric raise concerns about endocrine-disrupting effects, indicated by silico predictive models. Overall, our present study established robust identification shedding light on findings indicate exposure should be investigated, including health risks.

Language: Английский

Particle size-dependent and route-specific exposure to liquid crystal monomers in indoor air: Implications for human health risk estimations DOI
Huiju Lin, Xinxing Li, Xian Qin

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168328 - 168328

Published: Nov. 4, 2023

Language: Английский

Citations

11
Toxicity Assessment of Environmental Liquid Crystal Monomers: A Bacteriological Investigation on Escherichia coli and Staphylococcus epidermidis DOI
Yiquan Huang,

Qijun Ruan,

Shuting Fang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 6, 2024

The widespread existence of liquid crystal monomers (LCMs) in various environmental matrices has been demonstrated, yet studies on the toxicological effects LCMs are considerably scarce and urgently needed to be conducted assess adverse impacts ecology human health. Here, we a bacteriological study two representative commensal bacteria,

Language: Английский

Citations

4
Hepatotoxicity of Three Common Liquid Crystal Monomers in Mus musculus: Differentiation of Actions Across Different Receptors and Pathways DOI
Zhichao Zhang, Shengjie Yuan,

Zhongchao Yang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Liquid crystal monomers (LCMs) of different chemical structures were widely detected in various environmental matrices. However, their health risk evaluation is lacking. Herein, three representative LCMs selected from 74 LCM candidates upon literature review and acute cytotoxicity evaluation, then Mus musculus exposed to the for 42 days at doses 0.5 50 μg/kg/d investigate hepatotoxicity mechanisms. Phenotypic histopathological results showed that (DTMDPB, MeO3bcH, 5OCB) induced hepatomegaly, only 5OCB fatty liver. DTMDPB MeO3bcH decreased total cholesterol (TCHO) triglyceride (TG) content, whereas increased TCHO, TG, alanine aminotransferase levels. Transcriptome molecular docking analysis revealed by agonizing farnesoid X receptor, resulting disruption unsaturated acid biosynthesis, ascorbic antioxidant pathways, circadian clock homeostasis. promoted inflammation altered acid, primary bile rhythm antagonizing aryl hydrocarbon receptor. antagonized peroxisome proliferator-activated receptors, leading liver caused steroid, cholesterol, terpenoid backbone biosynthesis pathways. This study provides references understanding with selection priority control LCMs.

Language: Английский

Citations

0
Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation DOI Creative Commons
Shaohan Zhang, Zhipeng Cheng, Tao Zhang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 31, 2025

Embryonic and fetal development can be affected during gestation by exposure to xenobiotics that cross the placenta. Liquid crystal monomers (LCMs) are emerging contaminants commonly found in indoor environments; however, whether they placenta affect placental remains unexplored. Here, we develop an evaluation system integrates human biomonitoring, uterine perfusion pregnant rats, cells. We find fourteen out of fifty-six LCMs detected maternal cord serum samples from ninety-three healthy women, at median levels 13.9 18.1 ng/mL, respectively. Subsequent explorations utero rats indicate aromatic amino acid transporter 1 (SLC16A10) mediates transplacental transportation LCMs. Placental cells exposed exhibit delayed reduced progesterone release. These findings show SLC16A10-mediated inhibits release, highlighting importance gestational contaminants. contaminants; authors SLC16A10- mediated

Language: Английский

Citations

0
Fluorinated Liquid-Crystal Monomers Distribution in Paired Urine from Mothers and Infants DOI

Runhui Yang,

Yanli Zhang, Qun Gao

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126283 - 126283

Published: April 1, 2025

Language: Английский

Citations

0
Current trends and future directions in novel electrochemical innovations for wastewater treatment: A multidimensional critique on financial viability, life cycle sustainability, and circular economical benefits DOI
Shiam Babu Ramesh,

Narasamma Nippatlapalli

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 74, P. 107799 - 107799

Published: April 29, 2025

Language: Английский

Citations

0
Fluorinated liquid-crystal monomers in infant formulas and implication for health risk DOI

Runqing Liu,

Runhui Yang,

Jiang Qian

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 358, P. 124502 - 124502

Published: July 3, 2024

Language: Английский

Citations

3
Environmental behavior, toxic potencies, and risks of liquid crystal monomers: A critical review DOI

Jiawei Cheng,

Xiaojuan Li, Yawen Yuan

et al.

Critical Reviews in Environmental Science and Technology, Journal Year: 2024, Volume and Issue: 54(24), P. 1902 - 1919

Published: July 11, 2024

Language: Английский

Citations

3
Fluorinated Liquid-Crystal Monomers in Serum from the General Population and Their Impact on Human Health DOI

Runhui Yang,

Xin Xu, Xinyi Wang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(36), P. 15949 - 15959

Published: Aug. 15, 2024

Fluorinated liquid-crystal monomers (FLCMs) are a potential emerging class of persistent, bioaccumulative, and toxic compounds. Humans inevitably ingest FLCMs via food the environment. However, there limited studies on internal exposure biomonitoring FLCMs. Herein, we evaluated estimated daily intakes (EDIs) in general population based serum residue levels. For first time, 38 were detected 314 samples from Beijing, with median value 132.48 ng/g lipid weight (lw). BDPrB is predominant FLCM serum. The EDI ∑

Language: Английский

Citations

3
Multifaceted Insight into Sensitivity Analysis and Environmental Impact on Human Health of Soil Contamination Risk Assessment DOI Creative Commons
Hao Zhang, Ping Du,

Bei Yuan

et al.

Environment & Health, Journal Year: 2023, Volume and Issue: 1(3), P. 214 - 227

Published: Aug. 4, 2023

Sensitivity analysis is a valuable method for evaluating the impact of model parameters on health risk characterization, thereby supporting prediction critical uncertainty factors. However, limitations arise in terms cross-disciplinary discussions and in-depth analyses previous research. To overcome these limitations, systematic multifaceted approach was introduced analyzing parameter sensitivities soil contamination assessment. This specifically targeted 12 main associated with 65 contaminants assessment, employing detailed authoritative statistics Screening revealed that identified heavy metals organics were influenced by key parameters, such as PM10, body weight adults (BWa), daily air inhalation rate (DAIRa), exchange (ER), typical parameters. PM10 showed positive 100% correlation inorganics metals, but BWa DAIRa exhibited different impacts chemicals, an increase potential observed higher lower DAIRa. Furthermore, incorporating compact could improve protection against vapor organic compounds human health. refined study presents comprehensive strategy sensitivity assessment contamination, offering substantial support preservation A logical framework also provided addressing facilitating understanding complex relationships between contamination.

Language: Английский

Citations

7