ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(37)
Published: Oct. 6, 2023
Abstract
A
simple
and
beneficial
strategy
for
the
construction
of
2,3‐dihydrofurans
from
α‐bromochalcones
α‐substituted
cyanoketones
via
Michael
addition‐alkylation
reaction
has
been
realized.
This
transformation
was
well
compatible
with
various
cyanoketones,
corresponding
multifunctionalized
were
obtained
in
up
to
98
%
yield.
highly
diastereoselective
variant
also
developed.
Moreover,
could
be
performed
on
gram‐scale.
Organic & Biomolecular Chemistry,
Journal Year:
2021,
Volume and Issue:
19(14), P. 3087 - 3118
Published: Jan. 1, 2021
This
review
highlights
recent
developments
relating
to
the
preparation
of
β-keto
sulfones
and
thiosulfones.
And,
also
focused
on
widespread
synthetic
applications
for
assembling
many
valuable
carbo-
heterocycles.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(12), P. 8465 - 8471
Published: May 28, 2021
A
facile,
metal-free
method
for
the
synthesis
of
substituted
α-carbolines
from
secondary
Morita–Baylis–Hillman
(MBH)
acetates
nitroalkenes
is
presented.
The
cascade
reaction
MBH
with
tosyliminoindolines
occurs
regioselectively
to
form
various
a
wide
substrate
scope.
involves
mild
conditions,
and
products
are
formed
in
high
yields
within
short
time.
amenability
scale
up
synthetic
applications
have
been
demonstrated.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Trifluoromethyl
enone
emerges
as
a
versatile
and
multifaceted
building
block
in
organic
synthesis.
A
defluorinative
heterocyclization
reaction
of
readily
available
β,β-ditrifluoromethylated
enones
biocompatible
sodium
sulfinates
has
been
developed
for
the
modular
synthesis
densely
functionalized
furans
with
regio-defined
C2,4-bissulfonyl
C3-trifluoromethyl
substitutions.
This
three-component
method
proceeds
through
sequential
sulfonylation
intramolecular
O-cyclization,
enabling
assembly
one
furan
ring,
formation
C-SO2/C–O
bonds,
cleavage
three
C(sp3)-F
bonds
one-pot
manner
under
transition
metal-free
conditions.
Moreover,
obtained
product
can
further
react
benzyne
precursor
to
generate
1,4-epoxynaphthalene
Diels–Alder
cycloaddition.
The
is
also
distinguished
by
its
broad
substrate
scope,
excellent
functional
group
tolerance,
scalability.
Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
363(13), P. 3267 - 3282
Published: April 21, 2021
Abstract
A
synthetic
procedure,
catalysed
by
Ir(ppy)
3
under
visible‐light
irradiation,
for
the
chemodivergent
synthesis
of
2,3‐dihydrofurans
(
)
or
β,γ‐unsaturated
ketones
7
starting
from
α‐halo
1
and
alkenes
2
has
been
developed.
The
mild
reaction
conditions
redox‐neutral
nature
process
make
it
particularly
sustainable
avoiding
use
both
sacrificial
reactants
stoichiometric
strong
oxidants.
Careful
experimental
investigations,
supported
DFT
calculations,
allowed
to
disclose
in
details
a
possible
mechanistic
pathway
direct
chemodivergently
either
toward
,
depending
not
only
on
substrates,
but
also
choice
conditions.
magnified
image
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(31), P. 6243 - 6262
Published: Jan. 1, 2023
This
article
reviews
the
recent
applications
of
Morita–Baylis–Hillman
and
Rauhut–Currier
adducts
nitroalkenes.
It
also
covers
mechanistic
aspects,
including
key
intermediates
reaction
pathways.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(21), P. 14835 - 14846
Published: Jan. 1, 2024
In
this
work,
we
have
described
the
use
of
α-bromonitrostyrenes
in
synthesis
a
wide
variety
carbocyclic
and
heterocyclic
compounds
under
organocatalysis,
metal
catalysis,
base-catalysis
systems
as
well
catalyst-free
reactions.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(25), P. 5265 - 5273
Published: Jan. 1, 2023
Diastereoselective
formation
of
pyrrolidene-2-ylidenes
by
the
Huisgen
reaction
hydrogen-bond-assisted
azomethine
ylides
with
β-bromo-β-nitrostyrenes
is
reported.
