Synlett, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Abstract A novel one-pot cascade process of oxidation-initiated, N-heterocyclic carbene catalyzed, reintegration dibenzyl ethers has been developed for the first time. This protocol allows straightforward access to α-hydroxy ketones from ethers. It is noteworthy that present method attempt synthesize benzoin ether.
Language: Английский
Green Chemistry, Journal Year: 2023, Volume and Issue: 25(20), P. 7971 - 7977
Published: Jan. 1, 2023
Alkyl diacyl peroxides were demonstrated to be efficient alkylating reagents for the visible-light-induced 4CzIPN-catalyzed direct C–H alkylation of N -heteroaromatics.
Language: Английский
Citations
47
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(12), P. 7331 - 7336
Published: Jan. 1, 2024
A novel photocatalytic acylation strategy was developed harnessing tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst to facilitate the direct coupling of aldehydes with N-heterocycles at ambient temperature.
Language: Английский
Citations
17
Organic Letters, Journal Year: 2023, Volume and Issue: 25(20), P. 3739 - 3744
Published: May 15, 2023
We disclose a transition-metal-free NaI/PPh3-mediated direct C-H alkylation of azauracils using N-(acyloxy)pthalimides (NHPIs) as readily available alkyl surrogates under visible light irradiation. Detailed mechanistic studies reveal formation photoactivated electron donor-acceptor (EDA) complex between NaI/PPh3, TMEDA, and NHPI ester establish the crucial role TMEDA in increasing activity photoredox system. The reaction demonstrates broad scope, scalability, appreciable functional group tolerance. A variety are shown to undergo by primary, secondary, tertiary esters mild conditions, furnishing desired products good excellent yields.
Language: Английский
Citations
38
Organic Letters, Journal Year: 2024, Volume and Issue: 26(18), P. 3727 - 3732
Published: April 28, 2024
Photoexcitation electron donor-acceptor (EDA) complexes provide an effective approach to produce radicals under mild conditions, while the catalytic version of EDA complex photoactivation remains scarce. Herein, we report a visible-light-induced organophotocatalytic pathway for cyanoalkylation azauracils using inexpensive and readily available 1,4-diazabicyclo[2.2.2]octane (DABCO) as donor. This synthetic method exhibits exceptional compatibility with various functional groups presents 34 examples in high yields. The efficient offers environmentally friendly sustainable route toward enhancing structural diversity azauracils.
Language: Английский
Citations
11
Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7227 - 7232
Published: Aug. 20, 2024
We present an electrochemical alkylation of azauracils using N-(acyloxy)phthalimides (NHPI esters) as readily available alkyl radical progenitors under metal- and additive-free conditions. Several are shown to undergo with array NHPI esters (1°, 2°, 3°, sterically congested), providing the desired products in good excellent yields. This operationally simple method is robust, scalable, suitable for both batch flow setups.
Language: Английский
Citations
9
Green Chemistry, Journal Year: 2023, Volume and Issue: 25(14), P. 5721 - 5726
Published: Jan. 1, 2023
Herein, metal-free phosphonation of N-heterocycles with diphenylphosphine oxides, promoted by 1,5-diazabicyclo[5,4,0]undec-5-ene utilizing air as a green oxidant in dimethyl carbonate an eco-friendly solvent at room temperature, is presented.
Language: Английский
Citations
17
European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(8)
Published: Jan. 19, 2024
Abstract Over the past few years, organic chemistry has used dye rose bengal‘s ability to absorb visible light. In present‐day research, innovation of environmentally friendly processes for carbon‐carbon/carbon‐heteroatoms (Nitrogen, Oxygen, Sulphur, and Phosphorus) bond formation great importance. The photocatalyzed cross‐dehydrogenative coupling (CDC) reactions using bengal (RB) is a promising technique creating carbon‐carbon/carbon‐heteroatom bonds directly from readily available compounds. Our review focuses on current advancement in that uses bond‐making synthesize various important molecules via CDC reactions.
Language: Английский
Citations
6
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(27), P. 3665 - 3668
Published: Jan. 1, 2024
An innovative and eco-friendly method has been developed for synthesizing 6-arylated or 6-alkylated 1,2,4-triazine-3,5(2 H ,4 )-diones, utilizing a photoinduced cross-dehydrogenative coupling reaction with hydrazines.
Language: Английский
Citations
6
European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(7)
Published: Jan. 19, 2024
Abstract A Minisci‐type carbamoylation of azauracils was developed to afford 6‐carbamoyl in yields up 94 %. In this transformation, oxamic acids were employed as the carbamoyl radical sources under metal‐free conditions. It features high atom economy, good functional group compatibility and convenient operation.
Language: Английский
Citations
5
Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Comprehensive Summary Herein, we report a photo‐induced, metal‐/additive‐free protocol for the difluoromethylation of N ‐heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as reagent. The affords difluoromethylated in moderate to good yield (up 91%). transformation is compatible wide range substrates and has tolerance towards various functional groups. Moreover, synthetic value this method further demonstrated by applications gram‐scale synthesis late‐stage functionalization biologically important molecules.
Language: Английский
Citations
0