Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 25, 2023

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient’s quality of life. A disrupted barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components AD pathogenesis. Patients exhibit decreased expression antimicrobial peptides (AMPs) which linked to by . The microbiome itself source several AMPs. These host- microbiome-derived AMPs define landscape based on their differential activity against range microbes or quorum sensing inhibitory properties. particularly important in preventing limiting dysbiotic In addition, for immune homeostasis. this article, we share our perspectives about implications derived patients potential effects overlapping factors involved AD. We argue discuss bacterial as therapeutics

Language: Английский

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Recent developments in peptidomics for the quali-quantitative analysis of food-derived peptides in human body fluids and tissues

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 126, P. 41 - 60

Published: June 28, 2022

Language: Английский

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Peptidomics as a tool to analyze endogenous peptides in milk and milk-related peptides

Food Bioscience, Journal Year: 2022, Volume and Issue: 50, P. 102199 - 102199

Published: Nov. 13, 2022

Language: Английский

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Mass spectrometry‐based proteomics approaches to interrogate skeletal muscle adaptations to exercise

Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2023, Volume and Issue: 34(1)

Published: March 27, 2023

Acute exercise and chronic training elicit beneficial whole‐body changes in physiology that ultimately depend on profound alterations to the dynamics of tissue‐specific proteins. Since work accomplished during owes predominantly skeletal muscle, it has received majority interest from scientists attempt unravel adaptive mechanisms accounting for salutary metabolic effects performance improvements arise training. Contemporary are also beginning use mass spectrometry‐based proteomics, which is emerging as a powerful approach interrogate muscle protein signature more comprehensive manner. Collectively, these technologies facilitate analysis several viewpoints, including intracellular proteins (expression proteomics), secreted (secretomics), post‐translational modifications well fiber‐, cell‐, organelle‐specific changes. This review aims highlight recent literature leveraged new workflows advances proteomics further our understanding training‐related muscle. We call attention untapped areas research relating metabolism, basic points contention when applying analyses, particularly study human biology. encourage researchers couple hypothesis‐generating descriptive nature omics data with functional analyses propel complex responses occur acute exercise.

Language: Английский

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An omics review and perspective of researches on intrahepatic cholestasis of pregnancy

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Intrahepatic cholestasis of pregnancy (ICP) is one the common complications that may threaten health both pregnant women and their fetuses. Hence, it vital importance to identify key moleculars associated functional pathways ICP, which will help us better understand pathological mechanisms as well develop precise clinical biomarkers. The emerging developing multiple omics approaches enable comprehensive studies genome, transcriptome, proteome metabolome samples. present review collected summarized based aiming provide an overview current progress, limitations future directions. Briefly, these covered a broad range research contents by comparing different experimental groups including ICP patients, subtypes, fetuses, models other complications. Correspondingly, studied samples contain various types samples,

Language: Английский

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Origins, Technological Advancement, and Applications of Peptidomics

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 47

Published: Jan. 1, 2024

Language: Английский

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Network analysis of the proteome and peptidome sheds light on human milk as a biological system

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 30, 2024

Abstract Proteins and peptides found in human milk have bioactive potential to benefit the newborn support healthy development. Research has been carried out on health benefits of proteins peptides, but many questions still need be answered about nature these components, how they are formed, end up milk. This study explored elucidated complexity proteome peptidome. were analyzed with non-targeted nanoLC-Orbitrap-MS/MS a selection 297 samples from CHILD Cohort Study. Protein peptide abundances determined, network was inferred using Gaussian graphical modeling (GGM), allowing an investigation direct associations. showed that signatures (1) specific mechanisms transport different groups proteins, (2) proteolytic degradation by proteases aminopeptidases, (3) coagulation complement activation present These results show value integrated approach evaluating large-scale omics data sets provide valuable information for studies aim associate protein or profiles biofluids such as physiological characteristics.

Language: Английский

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Tools and technologies for biomarker discovery

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 63 - 82

Published: Jan. 1, 2025

Language: Английский

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Applications of Mass Spectrometry in the Characterization, Screening, Diagnosis, and Prognosis of COVID-19

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 33 - 61

Published: Jan. 1, 2024

Language: Английский

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Plasma/Serum Proteomics based on Mass Spectrometry

Protein and Peptide Letters, Journal Year: 2024, Volume and Issue: 31(3), P. 192 - 208

Published: March 1, 2024

Abstract: Human blood is a window of physiology and disease. Examination biomarkers in common clinical procedure, which can be informative diagnosis prognosis diseases, evaluating treatment effectiveness. There still huge demand on new assays for precision medicine nowadays, therefore plasma/serum proteomics has attracted increasing attention recent years. How to effectively proceed with the biomarker discovery diagnostic assay development question raised researchers who are interested this area. In review, we comprehensively introduce background advancement technologies proteomics, focus mass spectrometry (MS). Analyzing existing newly-built based MS shed light developing analytical methods. We summarize various protein analytes include total proteome, post-translational modifications, extracellular vesicles, focusing their corresponding sample preparation methods analysis. propose screening multiple same set samples order increase success rate discovery. also review trends techniques tests including automation, further provide our perspectives future directions.

Language: Английский

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