Amplified Cascade Catalysis for RAFT Polymerization

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

We report a conceptually new amplified cascade catalysis that converts oxygen to hydroxyl radical for controlled RAFT polymerization. This consists of two sequential reactions, deoxygenation catalyzed by glucose oxidase and Fenton reaction ferrocene. The catalysts can communicate with each other, leading ferrocene recycling hence amplification in generation. Ferrocene was confirmed UV/Vis spectroscopy, molecular docking simulation, electron paramagnetic resonance as well polymerization studies. applied various monomers, yielding well-defined homopolymers diblock copolymers weights low dispersities. Poly(N,N-dimethyl acrylamide) weight over 1 million g mol

Language: Английский

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Horseradish peroxidase-catalyzed polyacrylamide gels: monitoring their polymerization with BSA-stabilized gold nanoclusters and their functional validation in electrophoresis

RSC Advances, Journal Year: 2024, Volume and Issue: 14(4), P. 2182 - 2191

Published: Jan. 1, 2024

Polyacrylamide gel (PAG) is extensively used as a matrix for biomolecular analysis and fractionation. However, the traditional polymerization catalyst system N,N,N',N'-tetramethylethylenediamine (TEMED)/ammonium persulphate (APS) of PAG presents non-negligible toxicity. Herein, we utilized green efficient bio-enzyme horseradish peroxidase (HRP) to catalyze polyacrylamide. At same time, efficacy this in separating nucleic acids proteins was confirmed by applying electrophoresis. This study aims explore higher biosafety polyacrylamide catalytic which can be applied electrophoresis technology. Furthermore, order differentiate between bio-enzymatic toxic during polymerization, aggregation-induced luminescence (AIE) bovine serum albumin-stabilized gold nanoclusters (BSA-Au NCs) monitor reaction system. The results indicated that fluorescence intensity polymeric containing BSA-Au NCs increased with monomers. Subsequently, assessed whether certain components acid protein such sodiumdodecylsulfate (SDS) TBE buffer (Tris-boric acid, EDTA, pH 8.3) would affect gels catalyzed biological enzymes. experimental conditions were also optimized optimal concentration ternary HRP, H2O2 ACAC. Our suggested bioenzyme-catalyzed could feasible alternative TEMED/APS-catalyzed system, provide new insights into methods monitoring

Language: Английский

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Amide-Containing Bottlebrushes via Continuous-Flow Photoiniferter Reversible Addition–Fragmentation Chain Transfer Polymerization: Micellization Behavior

Polymers, Journal Year: 2023, Volume and Issue: 16(1), P. 134 - 134

Published: Dec. 31, 2023

Herein, a series of ternary amphiphilic amide-containing bottlebrushes were synthesized by photoiniferter (PI-RAFT) polymerization macromonomers in continuous-flow mode using trithiocarbonate as chain transfer agent. Visible light-mediated under mild conditions enabled the preparation thermoresponsive copolymers with low dispersity and high yields very short time, which is not typical for classical reversible addition–fragmentation process. Methoxy oligo(ethylene glycol) methacrylate alkoxy(C12–C14) used basic monomers providing properties. The study investigated how modifying comonomers, acrylamide (AAm), methacrylamide (MAAm), N-methylacrylamide (-MeAAm) affect features bottlebrush micelle formation, their critical concentration, loading capacity pyrene, hydrophobic drug model. results showed that process scalable can produce tens grams pure copolymer per day. unmodified formed unimolecular micelles at temperatures below LCST aqueous solutions, revealed DLS SLS data. incorporation AAm, MAAm, N-MeAAm units resulted an increase aggregation numbers. resulting uni- or bimolecular extremely concentrations. These possess making them promising choice targeted delivery.

Language: Английский

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Rationally designed block copolymer-based nanoarchitectures: An emerging paradigm for effective drug delivery

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(11), P. 103786 - 103786

Published: Sept. 22, 2023

Language: Английский

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Self-healing Polymers (SHPs) via Reversible Deactivation Radical Polymerization (RDRP): Syntheses, Property and Applications.

Polymer, Journal Year: 2024, Volume and Issue: 313, P. 127686 - 127686

Published: Oct. 9, 2024

Language: Английский

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