Modular Cascade of Flow Reactors: Continuous Flow Synthesis of Water‐Insoluble Diazo Dyes in Aqueous System DOI

Jihong Ouyang,

Wenbo Yang,

Zhaoyan Guo

et al.

ChemSusChem, Journal Year: 2024, Volume and Issue: unknown

Published: May 4, 2024

Abstract Continuous flow synthesis is pivotal in dye production to address batch‐to‐batch variations. However, synthesizing water‐insoluble dyes an aqueous system poses a challenge that can lead clogging. This study successfully achieved the safe and efficient of azo by selecting optimizing reactor modules for different reaction types two‐step implementing cascade cooperation. Integrating continuous microreactor with stirred tank (CSTR) enabled Sudan Yellow 3G without introducing water‐soluble functional groups or using organic solvents enhance solubility. Optimizing conditions (acidity/alkalinity, temperature, residence time) within initial modular resulted remarkable 99.5% isolated yield, 98.6 % purity, rate 2.90 g h −1 . Scaling‐up based on module characteristics further increased 74.4 while maintaining high yield purity. The construction this small 3D‐printing cascaded process scaling‐up provide technical support dyes, particularly high‐market‐share dyes. Moreover, versatile methodology proves applicable processes involving various homogeneous heterogeneous cascades.

Language: Английский

Sustainable and Scalable Amidations in Water Using Continuous Slurry-Flow Technology DOI Creative Commons

Saravanan Rajendran,

Sabrina Kogler,

Philipp Kögl

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Intensified reactors for a paradigm shift in chemical processing: the case for spinning disc reactors DOI Creative Commons
Arnab Chaudhuri, J. van der Schaaf

Current Opinion in Chemical Engineering, Journal Year: 2024, Volume and Issue: 46, P. 101052 - 101052

Published: Oct. 1, 2024

Language: Английский

Citations

3
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source DOI Creative Commons
Arnab Chaudhuri,

Wouter F.C. de Groot,

J. Schuurmans

et al.

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: 29(2), P. 460 - 471

Published: Jan. 14, 2025

Photochemical transformations have garnered renewed interest over the past decade for their ability to enable unique reactions under mild conditions. However, scaling up such processes, particularly in multiphase systems (e.g., gas–liquid), remains challenging. Previously, we demonstrated potential of photochemical rotor-stator spinning disc reactor (pRS-SDR) photooxidation α-terpinene ascaridole, though system was limited by light source, resulting suboptimal operation a photon-limited regime. In this work, unlock full pRS-SDR integrating high-powered source (up 652 W optical output) specifically designed reactor. The results show that high gas–liquid mass transfer rates achievable allow significant productivity improvements irradiance (16.3 kg day–1 at 92% conversion and 2.52 cm–2 27 mL irradiated volume), representing an order magnitude increase compared our previous study. β-citronellol exhibited notable limitations, highlighting importance selecting appropriate model when evaluating intensified reactors.

Language: Английский

Citations

0
HiGee process intensification in biorefineries: innovations, challenges, and outlook DOI Creative Commons
Kamelia Boodhoo, Fernando Russo Abegão

Current Opinion in Chemical Engineering, Journal Year: 2025, Volume and Issue: 48, P. 101119 - 101119

Published: March 29, 2025

Language: Английский

Citations

0
Modular Cascade of Flow Reactors: Continuous Flow Synthesis of Water‐Insoluble Diazo Dyes in Aqueous System DOI

Jihong Ouyang,

Wenbo Yang,

Zhaoyan Guo

et al.

ChemSusChem, Journal Year: 2024, Volume and Issue: unknown

Published: May 4, 2024

Abstract Continuous flow synthesis is pivotal in dye production to address batch‐to‐batch variations. However, synthesizing water‐insoluble dyes an aqueous system poses a challenge that can lead clogging. This study successfully achieved the safe and efficient of azo by selecting optimizing reactor modules for different reaction types two‐step implementing cascade cooperation. Integrating continuous microreactor with stirred tank (CSTR) enabled Sudan Yellow 3G without introducing water‐soluble functional groups or using organic solvents enhance solubility. Optimizing conditions (acidity/alkalinity, temperature, residence time) within initial modular resulted remarkable 99.5% isolated yield, 98.6 % purity, rate 2.90 g h −1 . Scaling‐up based on module characteristics further increased 74.4 while maintaining high yield purity. The construction this small 3D‐printing cascaded process scaling‐up provide technical support dyes, particularly high‐market‐share dyes. Moreover, versatile methodology proves applicable processes involving various homogeneous heterogeneous cascades.

Language: Английский

Citations

1