Synthesis of N‐Acyl Indole‐3‐Carboxaldehyde Derivatives and Polyvinyl Alcohol Acetalization with 1‐Propionylindole‐3‐Carboxaldehyde

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(18)

Published: May 10, 2024

Abstract A series of seven stable amide derivatives based on indole‐3‐carboxaldehyde were synthesized with high yields using various aliphatic and aromatic acyl chlorides, triethylamine DMAP as the catalyst at room temperature. Structural characterization was performed FT‐IR, 1 H‐NMR, 13 C‐NMR LC–MS techniques. To develop bioactive material, acetalization water‐soluble polyvinyl alcohol achieved by reacting one N‐acyl derivatives, 1‐propionylindole‐3‐carboxaldehyde, in presence a p‐TSA to form acetal pendant groups. The polymer analyzed TGA, DSC, FE‐SEM EDX spectroscopic water‐insoluble enhanced thermal stability compared pure alcohol. This approach for developing then monomers improve its properties humid conditions has proven successful.

Language: Английский

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Monodentate transient directing group promoted Pd-catalyzed direct ortho-C‒H arylation and chlorination of α-ketoesters for three-step synthesis of Cloidogrel racemate

Tetrahedron, Journal Year: 2022, Volume and Issue: 123, P. 132980 - 132980

Published: Aug. 19, 2022

Language: Английский

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Indole-3-Carboxaldehyde: N-Acylation and its Role in Polyvinyl Alcohol Acetalization

Published: Jan. 1, 2023

A series of seven stable amide derivatives based on indole-3-carboxaldehyde were synthesized with high yields using various aliphatic and aromatic acyl chlorides, triethylamine DMAP as the catalyst at room temperature. Structural characterization was performed FT-IR, 1H-NMR, 13C-NMR LC-MS techniques. To develop bioactive material, acetalization water-soluble polyvinyl alcohol achieved by reacting one N-acyl derivatives, 1-propionylindole-3-carboxaldehyde, in presence a p-TSA to form acetal pendant groups. The polymer analyzed TGA, DSC, FE-SEM EDX spectroscopic water-insoluble enhanced thermal stability compared pure alcohol. This approach for developing then monomers improve its properties humid conditions has proven successful.

Language: Английский

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Electrophilic Halogen Reagents-mediated Halogenation: Synthesis of Halogenated Dihydro-1,3-oxazine Derivatives

Chemical Research in Chinese Universities, Journal Year: 2022, Volume and Issue: 39(6), P. 933 - 947

Published: Nov. 21, 2022

Language: Английский

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