Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(22), P. 4688 - 4693
Published: Aug. 20, 2024
Abstract
Metal
hydride
catalyzed
hydrogen
atom
transfer
(MHAT)
reaction
of
1,6‐enyne
and
electron‐poor
alkene
progresses
through
a
radical
cascade,
involving
ene‐yne
cyclization
exocyclic
C−C
bond
formation
superseding
the
direct
reductive
olefin
cross‐coupling;
which
is
realized
in
current
study.
The
generality
this
manifold
demonstrated
with
range
functionalized
dienes
structurally
distinct
olefins
alkynes
as
partners.
Current
work
unveils
merger
MHAT‐based
olefin‐hydro
functionalization
ene‐one
cyclization.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(9), P. 6405 - 6415
Published: April 11, 2024
An
oxidative
cascade
iodocyclization
of
1,7-
or
1,8-dienes
has
been
realized
under
mild
conditions.
By
employing
I2
as
an
iodine
source,
this
protocol
provides
a
concise
and
efficient
approach
to
great
deal
biologically
significant
iodinated
benzo[b]azepine
benzo[b]azocine
derivatives
in
moderate
good
yields.
The
gram-scale
synthesis
further
transformation
products
render
the
practical
attractive.
Radical
trapping
deuterium-labeling
experiments
help
understand
mechanism.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(18)
Published: July 28, 2023
Abstract
The
synergistic
systems
of
photoredox
and
copper
catalyst
have
already
appeared
as
a
novel
formation
green
synthetic
chemistry,
which
open
new
avenues
for
chemical
synthesis
applications.
We
describe
strategy
the
cyclization
alkyne‐tethered
α
‐bromocarbonyls
initiated
by
cleavage
C(sp
3
)−Br
bond
via
collaboration
catalyst.
present
protocol
exhibits
mildness
using
economical
visible‐light
at
room
temperature.
gram‐scale
sunlight
irradiation
experiments
proceeded
smoothly
to
show
practicality
methodology.
It
is
notable
that
newly
generated
oxygen
in
product
originates
from
H
2
O.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(1), P. 687 - 691
Published: Dec. 15, 2023
An
iodoform-promoted
functionalization
of
ether
with
secondary
sulfonyl
amides
under
visible-light
irradiation
was
developed
toward
synthesis
hemiaminal
skeleton
good
to
excellent
isolated
yields.
The
characterization
the
and
iodoform
complex
revealed
regioselective
hydrogen
atom
transfer
initiate
carbon
radical
formation
enabled
amination
reaction
sulfonamide.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(22), P. 4688 - 4693
Published: Aug. 20, 2024
Abstract
Metal
hydride
catalyzed
hydrogen
atom
transfer
(MHAT)
reaction
of
1,6‐enyne
and
electron‐poor
alkene
progresses
through
a
radical
cascade,
involving
ene‐yne
cyclization
exocyclic
C−C
bond
formation
superseding
the
direct
reductive
olefin
cross‐coupling;
which
is
realized
in
current
study.
The
generality
this
manifold
demonstrated
with
range
functionalized
dienes
structurally
distinct
olefins
alkynes
as
partners.
Current
work
unveils
merger
MHAT‐based
olefin‐hydro
functionalization
ene‐one
cyclization.
