Chemistry - An Asian Journal,
Journal Year:
2022,
Volume and Issue:
18(4)
Published: Dec. 26, 2022
An
efficient
metal-free,
additive-free
synthetic
method
was
developed
to
access
benzooxepino-fused
pyrrole
derivatives
from
alkynyl
substituted
aziridines.
In
this
organic
transformation,
two
new
C-C
bonds
were
formed
via
initial
cleavage
of
bond
aziridine
ring
by
in
situ
generated
azomethine
ylides.
Moderate
excellent
yields
pyrroles
obtained
atom
economically
the
presence
t-BuOH
one-pot.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(1), P. 99 - 99
Published: Jan. 15, 2025
As
a
structural
and
catalytic
cofactor,
copper
is
involved
in
many
biological
pathways
required
for
the
biochemistry
of
all
living
organisms.
However,
excess
intracellular
can
induce
cell
death
due
to
its
potential
catalyze
generation
reactive
oxygen
species,
thus
homeostasis
strictly
regulated.
And
deficiency
or
accumulation
connected
with
various
pathological
conditions.
Since
success
platinum-based
compounds
clinical
treatment
types
neoplasias,
metal-based
drugs
have
shown
encouraging
perspectives
drug
development.
Compared
platinum,
an
essential
trace
element
that
may
better
prospects
development
than
platinum.
Recently,
therapeutic
role
copper-induced
autophagy
chronic
diseases
such
as
Parkinson’s,
Wilson’s,
cardiovascular
disease
has
already
been
demonstrated.
In
brief,
ions,
numerous
complexes,
copper-based
nano-preparations
could
autophagy,
lysosome-dependent
process
plays
important
human
diseases.
this
review,
we
not
only
focus
on
current
advances
elucidating
mechanisms
compounds/preparations
regulation
but
also
outline
association
between
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(37), P. 6761 - 6766
Published: Sept. 14, 2022
Gold(I)-catalyzed
efficient
synthetic
transformation
was
achieved
to
access
the
tetrahydrobenzo[h]cyclopropa[c]chromenes
from
allyl-substituted
1,6-diynes.
Cyclopropane-fused
tetrahydrobenzochromenes
were
obtained
regioselectively
in
≤92%
yields.
In
this
atom-economic
organic
transformation,
three
new
C-C
bonds
formed
sequentially
one
pot.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(21), P. 5705 - 5711
Published: Jan. 1, 2023
[1,3]-Nitrogen
rearrangement
reactions
of
O
-aryl
ketoximes
was
catalytically
promoted
by
IPrCuBr
and
BF
3
·OEt
2
.
The
oxidative
addition
the
N–O
bond
to
Cu
catalyst
is
accelerated
donation
electrons
from
both
nitrogen
oxygen
atoms.
Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
19(14)
Published: May 8, 2024
A
novel
gold
(I)-catalyzed
synthetic
strategy
has
been
achieved
for
an
efficient
construction
of
indenylidene
derivatives
from
substituted
1,6-diynes.
This
reaction
describes
the
unique
reactivity
catalysis
in
facilitating
intramolecular
[3,3]-sigmatropic
rearrangement,
5-exo
dig
cyclization
followed
by
1,5-migration
acryl
group,
resulting
formation
indenylidenes.
Various
indenylidenes
were
successfully
synthesized
with
up
to
92
%
yields.
In
this
protocol,
two
new
C-C
bonds
sequentially
formed
atom
economically
one
pot.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
25(1), P. 115 - 119
Published: Dec. 30, 2022
An
efficient
synthetic
method
was
developed
to
access
isoquinoline-derived
diene
esters
from
enynones
and
isoquinoline-N-oxides
in
an
atom-economic
manner.
The
isoquinoline-substituted
were
obtained
moderate
excellent
yields
via
[3
+
2]-cycloaddition
isoxazole
ring
opening
followed
by
a
[1,5]-sigmatropic
rearrangement
reaction,
which
resulted
one
C–C
two
C–O
bond
formations.
Further,
quinolin-2(1H)-ylidene-substituted
1,5-diones
achieved
reaction
of
with
quinoline-N-oxides
very
good
high
yields.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(10)
Published: Jan. 27, 2023
Abstract
An
efficient
method
for
the
regioselective
1,2‐hydrosilylation
of
N‐heteroarenes
is
reported
utilizing
silanes
as
hydride
donor.
The
ruthenium
complex
[RuCl(PPh
3
)
2
(η
5
‐(3‐phenylindenylidene))],
a
versatile
catalyst
is,
first
time,
employed
in
this
catalytic
reaction.
displays
high
efficiency
at
low
loading
and
operates
under
mild
conditions.
This
approach
showcases
compatibility
regioselectivity
with
quinolines
bearing
different
substituents
related
N‐
heterocyclic
compounds.
mechanism
transformation
was
probed
by
performing
stoichiometric
reactions
examined
using
DFT
calculations.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(15)
Published: June 21, 2023
Silver-catalyzed
N-aryl-1H-pyrazolyl
substituted
benzenesulfonamide
derivatives
were
obtained
regioselectively
from
ynamides
and
pyrazoles.
In
this
intermolecular
organic
transformation,
several
benzenesulfonamides
in
good
to
excellent
yields
by
forming
a
new
C-N
bond
under
mild
reaction
conditions.
