An
efficient
heterogeneous
catalytic
system
for
the
[4+2]
annulation
reactions
between
tertiary
anilines
and
tetrahydrofuran
has
been
developed
based
on
CuCoFe
layered
double
oxide
in
study.
Cu+
species
was
believed
to
play
crucial
role
transformation,
synergistic
effect
Cu
CoFe
observed
reaction.
Various
could
be
tolerated
by
present
system.
A
series
of
control
experiments
were
conducted
determine
reaction
intermediates.
distinctive
mechanism
described
these
results
kinetic
isotopic
effects
experiments.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(5), P. 2645 - 2652
Published: Jan. 1, 2024
A
unique
imine-based
covalent
organic
framework
heterogeneous
catalyst
with
missing-linker
defects
was
designed
and
synthesized,
the
exhibited
excellent
photocatalytic
activity
for
efficient
synthesis
of
tetrahydroquinolines.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
study
demonstrates
a
visible-light-driven
intramolecular
alkene
difluorination
enabling
Heck-type
coupling,
hydrofluoramidation,
and
difunctionalization.
Diverse
difluoro-γ-lactams
were
synthesized
with
high
selectivity
substrate
generality.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(9), P. 5471 - 5476
Published: Jan. 1, 2024
The
photocatalytic
α-aminoalkyl
radical
addition
of
amines
faciliated
by
benzophenone
is
disclosed.
This
an
example
a
alkylation
method
that
uses
low-toxicity
solvents
and
mild
reaction
conditions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(19), P. 3471 - 3475
Published: May 4, 2023
A
novel
persulfate-mediated
oxidative
glycosylation
system
using
p-methoxyphenyl
(PMP)
glycosides
as
bench-stable
glycosyl
donors
is
developed.
This
study
shows
that
both
K2S2O8
an
oxidant
and
Hf(OTf)4
a
Lewis
acid
catalyst
play
important
roles
in
the
activation
of
PMP
group
into
potential
leaving
group.
convenient
protocol
proceeds
under
mild
conditions
delivers
wide
range
biologically
synthetically
valuable
glycoconjugates,
including
fluorides.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(8), P. 1788 - 1808
Published: Jan. 5, 2024
Abstract
A
Ruthenium(II)
catalyzed
additive‐free
oxidative,
dehydrogenative
annulation
of
different
malemides
on
3,4‐disubstituted
isoquinolone
to
afford
fused
and
spiro‐cyclized
isoquinolo‐isoquinolone
isoindolo‐isoquinolone
derivatives
is
reported
here.
By
simply
changing
solvent
oxidizing
agents,
under
two
conditions,
this
methodology
produced
poly‐N‐heterocyclized
products.
Isoquinolone‐NH
was
strategically
used
as
the
internal
directing
group
in
ortho
C−H
activation
using
Ru(II)
catalyst.
Mechanistically
dehydrogenative,
oxidative
C−C
followed
by
C−N
cross‐coupling
aza‐michael
reaction
pathway
led
corresponding
spiro‐products
respectively.
diversified
library
eighty‐one
(81)
such
products
were
synthesized
employing
methodology.
The
spirocyclized
polyheterocyclic
compounds
absorbed
at
λ
max
240–270
nm
range,
however
only
spiro‐compounds
blue
fluorescence
em
391–450
range.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(42), P. 8579 - 8583
Published: Jan. 1, 2023
Tuning
the
electronic
structure
of
protecting
groups
on
nitrogen
atom
substrates
has
emerged
as
an
effective
strategy
to
achieve
tandem
trifluoromethylation/C(sp2)-H
annulation
using
Langlois'
reagent
CF3
source
for
electrochemical
synthesis
functionalized
tetrahydroquinolines
and
dihydroquinolinones.
Vietnam Journal of Catalysis and Adsorption,
Journal Year:
2024,
Volume and Issue:
13(1), P. 32 - 35
Published: March 30, 2024
Methods
for
using
commercially
available
copper
ferrite
nanoparticles
organic
transformations
have
witnessed
emerging
development.
Herein
we
expand
the
application
of
such
material
heterogeneously
catalytic
annulation
N,N-dimethylaniline
and
maleimides
to
yield
tetrahydroquinolines.
Using
developed
conditions,
a
73%
tetrahydroquinoline
derived
from
N-benzylmaleimide
4,N,N-trimethylaniline
was
isolated.
Derivatives
bearing
fluoro,
thiophenyl,
alpha-methylbenzyl
groups
were
also
obtained
with
yields
varying
54%
80%.
The
could
be
easily
separated
after
reaction
showed
nearly
identical
XRD
result
compare
that
fresh
material.
