The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(16), P. 10449 - 10458
Published: July 23, 2019
By
altering
the
amount
of
Selectfluor,
highly
selective
mono-
and
difluorination
1,3-dicarbonyl
compounds
has
been
achieved,
affording
a
variety
2-fluoro-
2,2-difluoro-1,3-dicarbonyl
in
good
to
excellent
yields.
The
reaction
can
be
readily
performed
aqueous
media
without
any
catalyst
base,
which
features
practical
convenient
fluorination.
Importantly,
gram-scale
reaction,
transformation
2-fluoro-1,3-diphenylpropane-1,3-dione
4-fluoro-1,3,5-triphenyl-1H-pyrazole,
chlorination
bromination
are
realized
further
exhibit
its
synthetic
utility.
Organic Chemistry Frontiers,
Journal Year:
2019,
Volume and Issue:
6(7), P. 1022 - 1026
Published: Jan. 1, 2019
A
photoredox-catalyzed
alkene
acyldifluoroalkylation
with
difluoroacetic
acids
for
the
direct
synthesis
of
gem-difluorinated
cyclic
ketones
is
developed.
Green Chemistry,
Journal Year:
2020,
Volume and Issue:
22(7), P. 2270 - 2278
Published: Jan. 1, 2020
A
highly
efficient
and
straightforward
approach
has
been
developed
for
the
synthesis
of
sulfone-functionalized
chroman-4-ones
chromans
through
visible-light-induced
cascade
radical
cyclization.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(7), P. 1319 - 1325
Published: Feb. 23, 2022
Abstract
An
atom
and
step
economy
cascade
trifluoromethylation/cyclization
of
unactivated
alkene
with
Langlois
reagent
as
a
CF
3
source
is
described.
A
variety
polycyclic
quinazolinones
were
successfully
synthesized
in
52–81%
yields
under
transition
metal‐
oxidant‐free
conditions.
The
used
this
strategy
possesses
the
advantages
bench‐stablity,
cost‐effectivity
high‐efficiency.
Additionally,
gram‐scale
reaction,
broad
substrate
scope
good
functional
group
tolerance
demonstrated
synthetic
usefulness
protocol.
magnified
image
European Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
2020(11), P. 1588 - 1597
Published: Dec. 2, 2019
Radical
cascade
cyclizations
of
o
‐allyloxybenzaldehydes
have
emerged
as
a
powerful
strategy
for
the
synthesis
3‐substituted
chroman‐4‐ones.
This
minireview
summarizes
incorporation
various
functional
groups
into
C3‐position
chroman‐4‐ones
by
employing
appropriate
radical
precursors
through
transition‐metal‐free
systems,
silver‐catalyzed
or
visible‐light‐promoted
systems.
Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
361(16), P. 3723 - 3728
Published: June 13, 2019
Abstract
By
taking
advantage
of
dimethyl
sulfoxide
(DMSO)
as
an
oxidant,
the
photoredox‐catalyzed
alkene
oxydifluoroalkylation
for
formal
C(
sp
3
)−CF
2
R
and
)=O
formation
is
disclosed
first
time.
This
difunctionalization
reaction
employs
readily
available
styrenes
substrates
bromodifluoro
compounds
difluoroalkylating
reagents,
which
can
afford
difluorinated
ketones
in
acceptable
yields
with
excellent
regioselectivity.
Experiments
indicate
that
fac
‐Ir(ppy)
‐catalyzed
proceed
smoothly
under
base‐free
conditions
presence
AgTFA.
magnified
image
Organic Chemistry Frontiers,
Journal Year:
2019,
Volume and Issue:
6(9), P. 1471 - 1475
Published: Jan. 1, 2019
A
convenient
silver-catalyzed
cascade
radical
cyclization
of
2-(allyloxy)arylaldehydes
with
cyclopropanols
was
developed
to
synthesize
carbonyl-containing
alkyl-substituted
chroman-4-one
derivatives.
