Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota DOI Creative Commons
Jing Zhang, Zhen Sun,

Lili Xu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.

Language: Английский

Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota DOI Creative Commons
Jing Zhang, Zhen Sun,

Lili Xu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.

Language: Английский

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