Cited by Rational design of pH-activated upconversion luminescent nanoprobes for bioimaging of tumor acidic microenvironment and the enhancement of photothermal therapy

Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment DOI

Yuting Xiang,

Qiaohui Chen,

Yayun Nan

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(13)

Published: Dec. 21, 2023

Abstract Almost all cancer treatments are significantly limited by the strong tumor microenvironment (TME) fortress formed abnormal vasculature, dense extracellular matrix (ECM), multidrug resistance (MDR) system, and immune “cold” environment. In huge efforts of dismantling TME fortress, nitric oxide (NO)‐based nanomedicines increasingly occupying a central position have already been identified as super “strong polygonal warriors” to dismantle for efficient treatment, benefiting from NO's unique physicochemical properties extremely fascinating biological effects. However, there is paucity systematic review elaborate on progress fundamental mechanism NO‐based in oncology this aspect. Herein, key characteristics potential NO reprogramming delineated highlighted. The evolution donors advantages discussed subsequently. Moreover, latest solid tumors comprehensively reviewed, including normalizing overcoming ECM barrier, reversing MDR, reactivating immunosuppression TME. Lastly, prospects, limitations, future directions manipulation provide new insights into construction more applicable anticancer nanomedicines.

Language: Английский

Citations

Cupric-ion-promoted fabrication of oxygen-replenishing nanotherapeutics for synergistic chemo and photodynamic therapy against tumor hypoxia DOI

Lin He,

Feijie Xu, Yongxin Li

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 162, P. 57 - 71

Published: March 20, 2023

Language: Английский

Citations

Current trends in gas-synergized phototherapy for improved antitumor theranostics DOI

Ziwei Yan, Zhu Liu, Haotian Zhang

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 174, P. 1 - 25

Published: Dec. 12, 2023

Language: Английский

Citations

Copper‐Based Metal‐Organic Framework Induces NO Generation for Synergistic Tumor Therapy and Antimetastasis Activity DOI

Debao Ren,

Yibin Cheng, Wenxuan Xu

et al.

Small, Journal Year: 2022, Volume and Issue: 19(4)

Published: Nov. 24, 2022

The interaction between platelets and circulating tumor cells (CTCs) contributes to distal metastasis by protecting CTCs from immunological assault shear stress, which can be disrupted nitric oxide (NO) through inhibiting platelet-mediated adhesion. To eradicate primitive tumors inhibit CTC-based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed encapsulating Cu+ -responsive S-nitrosoglutathione as NO donor into copper-based metal-organic framework (CuM). This work discovers that mCuMNO target regions deplete local glutathione (GSH) reduce Cu2+ , followed triggering release hydroxyl radicals (·OH) production, thereby interrupting platelet/CTC interplay contributing chemodynamic therapy. Detailed studies demonstrate exhibits high efficiency safety in therapy antimetastasis activity, sheding new light on the development of CuM-based synthetic

Language: Английский

Citations

Rational design of pH-activated upconversion luminescent nanoprobes for bioimaging of tumor acidic microenvironment and the enhancement of photothermal therapy DOI

Baojin Tan,

Chao Zhao, Jing Wang

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 155, P. 554 - 563

Published: Sept. 8, 2022

Language: Английский

Citations