The role of neutrophils in osteosarcoma: insights from laboratory to clinic DOI Creative Commons
Ming Xia, Yu Han,

Lihui Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the intricate interactions within its tumor microenvironment (TME), particularly involving neutrophils. This review delineates multifaceted roles of neutrophils, including tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), in osteosarcoma’s pathogenesis. TANs exhibit both pro- anti-tumor phenotypes, modulating growth immune evasion, while NETs facilitate cell adhesion, migration, immunosuppression. Clinically, neutrophil-related markers such as neutrophil-to-lymphocyte ratio (NLR) predict patient outcomes, highlighting potential for neutrophil-targeted therapies. Unraveling these complex crucial developing novel treatment strategies that harness TME to improve osteosarcoma management.

Language: Английский

Disrupting the dangerous alliance: Dual anti-inflammatory and anticoagulant strategy targets platelet-neutrophil crosstalk in sepsis DOI

Sa Chen,

Aijia Wu,

Xinran Shen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 814 - 831

Published: Jan. 28, 2025

Language: Английский

Citations

1
Nanocapsuled Neutrophil Extracellular Trap Scavenger Combating Chronic Infectious Bone Destruction Diseases DOI Creative Commons

Siying Tao,

Yingming Yang,

Chenzhou Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Abstract Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative. The retention of neutrophil extracellular traps (NETs) in niches found be barrier inflammation resolution. However, whether ruining existing NETs within local lesions can contribute resolve and repair understudied. Herein, nanocapsuled delivery system that scavenges dual‐responsively near‐infrared light switch themselves microenvironment sensor designed. Besides, photothermal photodynamic effects endow nanocapsules with antibacterial properties. Together ability clear NETs, features facilitate restoration normal response. immunocorrective properties inherent pro‐osteogenic finally promote repair. Together, NET scavenging address challenge impaired due biased response excessive NETs. This study provides new concepts strategies for repairing attributable via correcting responses diseases.

Language: Английский

Citations

0
Physicochemical Design of Nanoparticles to Interface with and Degrade Neutrophil Extracellular Traps DOI Creative Commons
Preethi Raghavan,

Cynthia A. Perez,

Thomas A. Sorrentino

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(6), P. 8862 - 8874

Published: Jan. 30, 2025

Neutrophil extracellular traps (NETs) are networks of decondensed chromatin, histones, and antimicrobial proteins released by neutrophils in response to an infection. NET overproduction can cause exacerbated hyperinflammatory a variety diseases lead host tissue damage without clearance Nanoparticle drug delivery is promising avenue for creating materials that both target NETs deliver sustained amounts NET-degrading drugs alleviate hyperinflammation. Here, we study how particle physicochemical properties influence interaction leverage our findings create NET-interfacing particles. We fabricated panel particles varying sizes (200 1000 nm) charges (positive, neutral, negative) found positive charge the main driver NET-particle interaction, with smaller 200 nm having 10-fold increase binding compared larger Negative neutral were mostly noninteracting, except small negatively charged exhibited very low levels localization. Interaction strength was quantified via shear flow assays atomic force microscopy. This information leveraged DNase-loaded could adhere at degrees therefore degrade different rates vitro. Positively charged, showed highest degree led faster degradation sizes, underscoring importance design NET-targeting delivery. Overall, this work provides fundamental knowledge drivers particle-NET basis designing various disease states.

Language: Английский

Citations

0
Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics DOI Creative Commons
Haisong Li, Can Li, Cong Fu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, tumors. While they help capture eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly achieving precise drug delivery maintaining stability. Nanoparticle (NP)-based systems offer innovative solutions for overcoming limitations conventional therapies. This review explores biological mechanisms formation, their interactions with NPs, therapeutic applications NP-based modulating NETs. We discuss how NPs be designed either promote inhibit provide a comprehensive analysis potential treating NET-related diseases. Additionally, we address current future prospects therapies research, aiming bridge gap between nanotechnology development novel approaches.

Language: Английский

Citations

0
Neutrophil Extracellular Traps: Emerging Biomarker and Prototype of Functional Materials DOI Open Access
Bo Pang, Liping Wen, Linlin Zheng

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Functional biomaterials composed of multiple biomacromolecules have significant advantages over those made from a single type. However, harmoniously integrating various remains challenging. Neutrophil extracellular traps (NETs), an emerging biological structure released neutrophils, serve as natural prototype worth investigating and learning from. NETs consist intricate exhibit web‐like microstructure, endowing them with multifaceted roles in both physiological pathological processes. In this review, research progress is systematically examined on materials science perspective. First, the origin transformation are introduced, their functional mechanisms NET components thoroughly dissected rather than conventionally treating entity. Second, given complex functions, revealed potential biomarker for disease prediction. Third, typical characterization technologies analysis summarized. Fourth, artificial inspired by discussed. addition, regulatory processes provide bio‐inspired prototypes design advanced materials. Finally, perspectives opportunities challenges advancing presented biomarkers models development

Language: Английский

Citations

0
Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage DOI Creative Commons

Linghui Kong,

Song Hu, Ying Zhao

et al.

Breast Cancer Research, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 23, 2025

The mechanisms underpinning neoadjuvant chemotherapy-induced vascular endothelial injury in breast cancer remain elusive. Our study aims to demonstrate that Neutrophil Extracellular Traps (NETs) play a pivotal role cancer, elucidating upregulation of Solute Carrier 11a1 (Slc11a1) modulates Reactive Oxygen Species (ROS) generation, which may be critical for NETs formation. We investigated the impact chemotherapy on formation and by analyzing dsDNA serum markers patients, cells, mouse models. RNA sequencing neutrophils from models was performed identify potential formation-associated gene Slc11a1, further validated through cellular animal experiments assessing Slc11a1 expression, intracellular ferrous ion content, ROS levels. Knockdown human were also confirm phenotypic results. revealed plasma significantly elevated patients undergoing docetaxel & carboplatin (TCb) chemotherapy, compared controls. In these associated with augmentation markers. Chemotherapy demonstrated TCb treatment markedly injury, can mitigated CI-amidine, protein-arginine deiminase inhibitor. neutrophils, we chemotherapeutic agents (combination carboplatin) induced NETs, subsequently facilitated damage umbilical vein cells vitro. identified as key formation-related gene, upregulated leading increased content generation. its reversal effect TCb-induced upregulation, research underscores capacity augment Slc11a1-mediated is linked injury. elucidates underlying perioperative offering novel insights into therapeutic management strategies patients.

Language: Английский

Citations

0
Global research trends and focus on the link between neutrophil extracellular traps and tumor: a bibliometric and visualization analysis from 2006 to 2024 DOI Creative Commons

Chaoyue Xiao,

Xiang Feng,

Zengyi Zhao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 24, 2024

Background Neutrophil extracellular traps (NETs) have long been consistently considered an innate immune defense against foreign pathogens, but this oversimplified view has decelerated the progression of perceiving NET biology in chronic diseases. It is now increasingly accepted that NETs are not exclusive to anti-infection responses, also central players with a double-edged sword role cancer progression. gradually emerged as tumor diagnostic, predictive, and prognostic biomarkers, strenuous endeavors devoted tapping their potential new therapeutic targets. Correspondingly, boom studies on tumors recent years achieved series scientific outputs, which opens up perspective for sophisticated landscapes microenvironment. However, there still much room translate NET-targeted immunotherapies into clinical practice. Therefore, it necessary explore knowledge structure latent hotspots links between using bibliometric analysis. Methods publications from 2006 2024 were extracted Web Science Core Collection. Bibliometric analysis visualization conducted Microsoft Excel, VOSviewer, CiteSpace, R-bibliometrix. Results The included 1,339 authored by 7,747 scholars affiliated 1,926 institutions across 70 countries/regions relevant articles published 538 journals. Despite China’s maximum number publications, United States continued dominate field global cooperation center overwhelming citation counts. Frontiers Immunology most whereas Blood was cited journal. Wagner, Denisa D. Kaplan, Mariana J. concurrently both top 10 prolific authors author lists. Tumor microenvironment immunotherapy will likely be focus future research. Conclusions A comprehensive first map current landscape link hope providing guidance fresh perspectives further research field. promising antitumor targets, perhaps eventual destination realm

Language: Английский

Citations

1
The role of neutrophils in osteosarcoma: insights from laboratory to clinic DOI Creative Commons
Ming Xia, Yu Han,

Lihui Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the intricate interactions within its tumor microenvironment (TME), particularly involving neutrophils. This review delineates multifaceted roles of neutrophils, including tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), in osteosarcoma’s pathogenesis. TANs exhibit both pro- anti-tumor phenotypes, modulating growth immune evasion, while NETs facilitate cell adhesion, migration, immunosuppression. Clinically, neutrophil-related markers such as neutrophil-to-lymphocyte ratio (NLR) predict patient outcomes, highlighting potential for neutrophil-targeted therapies. Unraveling these complex crucial developing novel treatment strategies that harness TME to improve osteosarcoma management.

Language: Английский

Citations

0