European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117321 - 117321
Published: Jan. 1, 2025
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114770 - 114770
Published: March 7, 2023
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains huge challenge due multiple barriers that significantly the ultimate therapeutic efficacy drugs. Recent advances in nanocarrier technology offer promising opportunity overcome these by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, targeted loaded eyes. This review primarily provides an overview progress contemporary applications nanocarriers, mainly polymer- lipid-based treating various eye highlighting their value achieving delivery. Additionally, covers administration routes, as well prospective future developments challenges field nanocarriers for diseases.
Language: Английский
Citations
151
Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075
Published: April 24, 2022
Language: Английский
Citations
130
Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)
Published: Feb. 1, 2023
Owing to the increase in multidrug-resistant bacterial isolates hospitals globally and lack of truly effective antimicrobial agents, antibiotic resistant infections have increased substantially. There is thus an urgent need develop new drugs their related formulations. In recent years, natural peptides (AMPs), AMP optimization, self-assembled AMPs, hydrogels, biomaterial-assisted delivery AMPs shown great potential treatment infections. this review, it focused on development prospects shortcomings various AMP-based biomaterials for treating animal model infections, such as abdominal, skin, eye It hoped that review will inspire further innovations design accelerate commercialization.
Language: Английский
Citations
130
Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)
Published: Feb. 12, 2023
Abstract Photothermal therapy (PTT) has emerged as an attractive technique for the treatment of bacterial infections. However, uncontrolled heat generation in conventional PTT inevitably causes thermal damages to healthy tissues and/or organs. It is thus essential develop a smart and universal strategy regulate photothermal equilibrium temperature preset safe threshold. Herein, thermoresponsive hydrogel‐enabled thermostatic system enhanced healing bacteria‐infected wounds reported. In this system, near‐infrared (NIR)‐triggered by nanomaterials spontaneously transferred hydrogel with lower critical solution (LCST), leading its rapid phase transition forming considerable light‐scattering centers block NIR penetration. Such dynamic reversible process automatically regulates phase‐transition point LCST‐type hydrogel. contrast temperature‐uncontrolled severe damages, provides effective protection on organs, which remarkably accelerates wound efficient eradication. This study establishes smart, simple platform, holding great promise skin
Language: Английский
Citations
78
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(29)
Published: May 5, 2023
Drug-resistant bacteria and biofilm-associated infections are prominent problems in the field of antibacterial medicine, seriously affecting human animal health. Despite great potential nanomaterials field, overcoming paradox size charge, efficient penetration, retention within biofilms remain a formidable challenge. Here, self-assembling chimeric peptide nanoassemblies composed multiple functional fragments designed for treatment drug-resistant infections. Notably, self-assembles into nanofibers at pH 7.4 is transformable nanoparticles acidic biofilm-infected microenvironment 5.0, thus achieves reduction charge increase, improving penetration bacterial killing by mechanism dominated membrane cleavage. In vivo mouse piglet infection models confirm ability to reduce load biofilms. Collectively, this research on pathological-environment-driven nanostructural transformations may provide theoretical basis designing high-performance advance application peptide-based medicine husbandry.
Language: Английский
Citations
57
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(23)
Published: Feb. 28, 2023
Abstract To tackle the problems caused by bacterial biofilms, herein, this study reports an antimicrobial hybrid amphiphile (aHA) via dynamic covalent bonds for eradicating staphylococcal biofilms. aHA is synthesized iminoboronate ester formation between DETA NONOate (nitric oxide donor), 3 4‐dihydroxybenaldehyde, and phenylboronic acid‐modified ciprofloxacin (Cip). can self‐assemble in aqueous solution with ultra‐small critical aggregation concentration of 3.80 × 10 –5 m high drug loading content 73.8%. The sensitive to acidic oxidative biofilm microenvironment, liberating nitric Cip that synergistically eradicate end, assemblies efficiently infections ameliorate inflammation murine peritoneal subcutaneous infection models without any notable side effects on normal tissues. Collectively, may provide a facile efficient alternative current development anti‐biofilm therapies.
Language: Английский
Citations
52
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(35)
Published: May 26, 2023
Cationic photosensitizers have good binding ability with negatively charged bacteria and fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT). However, cationic often display unsatisfactory transkingdom selectivity between mammalian cells pathogens, especially for eukaryotic fungi. It is unclear which biomolecular sites are more efficient damage, owing to the lack of systematic research same photosensitizer system. Herein, a series aggregation-induced emission (AIE) derivatives (CABs) (using berberine (BBR) as core) different length alkyl chains successfully designed synthesized flexible modulation cellular activities. The BBR core can efficiently produce reactive oxygen species (ROS) achieve high-performance aPDT . Through precise regulation chain length, bindings, localizations, killing effects CABs achieved investigated systematically among bacteria, cells. found that intracellular active substances, not membranes, damage aPDT. Moderate enable effectively kill Gram-negative fungi light, while still maintaining excellent cell blood compatibility. This study expected provide theoretical strategic guidance construction selectivity.
Language: Английский
Citations
46
Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 141, P. 101679 - 101679
Published: April 23, 2023
Language: Английский
Citations
45
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Nov. 18, 2023
The formation of biofilms is closely associated with persistent and chronic infections, physiological heterogeneity such as pH oxygen gradients renders highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication micellar nanoparticles adapted heterogeneous microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. key design feature involves use tertiary amine (TA) moieties, which function sacrificial agents avoid quenching photocatalysts under normoxic neutral conditions proton acceptors at acidic allow deep penetration. This biofilm-adaptive NO-releasing platform shows excellent antibiofilm activity against ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) both in vitro mouse skin infection model, providing strategy for combating biofilm-related infections.
Language: Английский
Citations
45
Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)
Published: Feb. 13, 2024
Abstract Wounds infected with multidrug‐resistant (MDR) bacteria are increasingly threatening public health and challenging clinical treatments because of intensive bacterial colonization, excessive inflammatory responses, superabundant oxidative stress. To overcome this malignant burden promote wound healing, a multifunctional cryogel (HA/TA2/KR2) composed hyaluronic acid (HA), tannic (TA), KR‐12 peptides is designed. The exhibited excellent shape‐memory properties, strong absorption performance, hemostatic capacity. In vitro experiments demonstrated that in the can be responsively released by stimulation hyaluronidase produced bacteria, reaching robust antibacterial activity against Escherichia coli ( E. coli) , MDR Pseudomonas aeruginosa (MDR‐PA), methicillin‐resistant Staphylococcus aureus (MRSA) disrupting cell membranes. Furthermore, synergetic effect TA efficiently scavenge ROS decrease expression pro‐inflammatory cytokines (tumor necrosis factor (TNF)‐α & interleukin (IL)−6), as well modulate macrophage phenotype toward M2 type. vivo animal tests indicated effectively destroy healing process via accelerating angiogenesis re‐epithelialization. Proteomic analysis revealed underlying mechanism which mainly reshaped microenvironment inhibiting Nuclear kappa B (NF‐κB) signaling pathway activating Janus kinase‐Signal transducer activator transcription (JAK‐STAT6) pathway. Therefore, HA/TA2/KR2 promising dressing candidate for bacteria‐infected healing.
Language: Английский
Citations
40