The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(17), P. 12658 - 12667
Published: Aug. 19, 2024
Nickel/photoredox
catalysis
has
emerged
as
a
powerful
platform
for
exploring
nontraditional
and
challenging
cross-couplings.
Herein,
metallaphotoredox
catalytic
protocol
been
developed
on
the
basis
of
tertiary
amine-ligated
boryl
radical-induced
halogen
atom
transfer
process
under
blue-light
irradiation.
A
wide
variety
aryl
heteroaryl
bromides
featuring
different
functional
groups
pharmaceutical
moieties
were
facilely
coupled
to
rapidly
install
C(sp3)-enriched
aromatic
scaffolds.
The
compatibility
Lewis
base-ligated
borane
with
nickel
was
well
exemplified
extend
chemical
space
Ni-catalyzed
cross-electrophile
coupling.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(14)
Published: Jan. 5, 2024
Bicycloalkanes,
cubanes
and
their
structural
analogues
have
emerged
as
bioisosteres
of
(hetero)arenes.
To
meet
increasing
demand,
the
chemical
community
has
developed
a
plethora
novel
synthetic
methods.
In
this
review,
we
assess
progress
made
in
field
light-driven
construction
functionalization
such
relevant
molecules.
We
focused
on
diverse
targets,
well
reaction
processes
giving
access
to:
(i)
[1.1.1]-bicyclopentanes
(BCPs);
(ii)
[2.2.1]-bicyclohexanes
(BCHs);
(iii)
[3.1.1]-bicycloheptanes
(BCHeps);
(iv)
cubanes;
other
structurally
related
scaffolds.
Finally,
future
perspectives
dealing
with
identification
manifolds
to
new
functionalized
bioisosteric
units
are
discussed.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 23, 2024
Abstract
Natural
stilbenes
have
shown
significant
potential
in
the
prevention
and
treatment
of
diseases
due
to
their
diverse
pharmacological
activities.
Here
we
present
a
mild
effective
Ti-catalyzed
intermolecular
radical-relay
[2σ
+
2π]
cycloaddition
bicyclo[1.1.0]-butanes
1,3-dienes.
This
transformation
enables
synthesis
bicyclo[2.1.1]hexane
(BCH)
scaffolds
containing
aryl
vinyl
groups
with
excellent
regio-
trans
-selectivity
broad
functional
group
tolerance,
thus
offering
rapid
access
structurally
stilbene
bioisosteres.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Rigid
bicyclic
hydrocarbons
have
emerged
as
important
building
blocks
in
the
drug
discovery
industry.
Despite
progress
this
general
area,
bicyclo[2.1.0]pentanes
(housanes)
are
an
understudied
class
of
molecules.
Herein
we
report
unconventional
synthesis
borylated
housanes.
Our
method
features
a
broad
scope
and
high
diastereoselectivities
versatile
intermediates.
The
route
involves
strain-release
diboration
bicyclo[1.1.0]butane
intramolecular
deborylative
alkylation.
versatility
bridgehead
boronic
ester
was
demonstrated
several
functionalizations.
Lastly,
mechanism
reaction
investigated,
unusual
stereospecific
diastereoselective
ring
expansion
uncovered.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(50), P. 6340 - 6361
Published: Jan. 1, 2024
In
this
review,
the
state-of-the-art
advances
in
radical-involved
C(sp
3
)–N
bond
formation
via
metallaphotoredox
catalysis
have
been
highlighted,
which
are
organized
according
to
different
catalytic
modes,
reaction
types,
and
substrate
classes.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Cross-electrophile
coupling
(XEC),
defined
by
us
as
the
cross-coupling
of
two
different
σ-electrophiles
that
is
driven
catalyst
reduction,
has
seen
rapid
progression
in
recent
years.
As
such,
this
review
aims
to
summarize
field
from
its
beginnings
up
until
mid-2023
and
provide
comprehensive
coverage
on
synthetic
methods
current
state
mechanistic
understanding.
Chapters
are
split
type
bond
formed,
which
include
C(sp
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(6), P. 4322 - 4345
Published: March 8, 2024
Photochemistry
has
emerged
as
a
transformative
force
in
organic
chemistry,
significantly
expanding
the
chemical
space
accessible
for
medicinal
chemistry.
Light-induced
reactions
enable
efficient
synthesis
of
intricate
structures
and
have
found
applications
throughout
different
stages
drug
discovery
development
processes.
Moreover,
photochemical
techniques
provide
innovative
solutions
biology,
allowing
precise
spatiotemporal
activation
targeted
delivery.
In
this
Perspective,
we
highlight
already
numerous
remarkable
even
more
promising
future
photochemistry
chemistry
biology.
