Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101678 - 101678
Published: May 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 5, 2024
Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.
Language: Английский
Citations
85
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 421 - 439
Published: Jan. 16, 2025
Aerosol delivery represents a rapid and non-invasive way to directly reach the lungs while escaping hepatic first-pass effect. The development of pulmonary drugs for respiratory diseases such as cystic fibrosis, lung infections, fibrosis or cancer requires an enhanced understanding relationships between natural physiology system pathophysiology these conditions. This knowledge is crucial better predict thereby control drug deposition. Moreover, aerosol administration faces several challenges, including tract, immune system, mucociliary clearance, presence fluid on airway surfaces, and, in some cases, bacterial colonisation. Each them influences bioavailability active molecule. In addition particle size device used administer treatment are critical factors that can significantly impact biodistribution drugs. Nanoparticles very promising new formulations delivery, they be fine-tuned entire tract overcome difficulties encountered along way. However, properly assess preclinical studies need more thorough efficiently enhance delivery.
Language: Английский
Citations
1
Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)
Published: Nov. 30, 2024
Abstract Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since discovery in 2012, extensive research has demonstrated pivotal roles tumorigenesis, metastasis cancer therapy. The tumor microenvironment (TME) complex ecosystem comprising cells, non-cancer extracellular matrix, metabolites cytokines. Recent studies have underscored new paradigm which cells the TME, such as immune stromal also play significant regulating progression therapeutic resistance typically through complicated crosstalk with cells. Notably, this TME were partially mediated ferrotopsis-related mechanisms. This review provides comprehensive systematic summary current findings concerning ferroptosis how ferroptosis-mediated reprogramming impacts progression. Additionally, outlines various ferroptosis-related strategies aimed at targeting TME.
Language: Английский
Citations
8
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969
Published: June 10, 2024
Language: Английский
Citations
7
ACS Nano, Journal Year: 2024, Volume and Issue: 18(37), P. 25685 - 25694
Published: Sept. 2, 2024
Phosphates within tumors function as key biomolecules, playing a significant role in sustaining the viability of tumors. To disturb homeostasis cancer cells, regulating phosphate organism proves to be an effective strategy. Herein, we report single-atom Ce-doped Pt hydrides (Ce/Pt-H) with high phosphatase-like activity for hydrolysis. The resultant Ce/Pt-H exhibits 26.90- and 6.25-fold increase comparison Ce/Pt Pt-H, respectively. Mechanism investigations elucidate that Ce Lewis acid site facilitates coordination groups, while surface enhance electron density promoting catalytic ability H
Language: Английский
Citations
7
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 442(1), P. 114198 - 114198
Published: Aug. 3, 2024
Language: Английский
Citations
6
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 324, P. 103087 - 103087
Published: Jan. 11, 2024
Language: Английский
Citations
5
Polyoxometalates, Journal Year: 2025, Volume and Issue: 4(1), P. 9140074 - 9140074
Published: March 1, 2025
In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases vitro vivo, their main therapeutic mechanisms are related to generation reactive oxygen species causing oxidative stress. The site production is mitochondria, therefore, mechanism may be mitochondrial biosynthesis. This paper describes one diabetes mellitus, which involves increase species, resulting stress; at same time, preliminarily as antioxidants antitumor mellitus tumors, antioxidant properties provide an additional possibility for future a drug disease treatment; on basis study stress biomolecule due it, associating therapy actually closely through biosynthesis regulation relationship between mitochondria its impact three aspects order in-depth role drugs aspects.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
To simplify the composition and improve efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to deliver programmed death ligand-1 (PD-L1) antibody (anti-PD-L1) for combined tumor chemo/chemodynamic/immune therapy. Here, generation 5 poly(amidoamine) dendrimers conjugated with gossypol (Gos) through boronic ester bonds were used as a synthetic polyphenol coordinate Mn2+, then complexed anti-PD-L1 obtain nanocomplexes (for short, DPGMA). The prepared DPGMA exhibited good water dispersibility hydrodynamic size 166.3 nm tumor-microenvironment-responsive drug release behavior. integration Gos Mn2+ within resulted in significant inhibition immunogenic cell activation Gos-mediated chemotherapy Mn2+-catalyzed chemodynamic therapy, respectively, thereby leading dendritic maturation due role played mediate stimulator interferon genes (STING) pathway. Moreover, promoted recognition uptake by PD-L1-overexpressed tumors targeting, achieving combinational therapy mouse melanoma model, where immunotherapy modes three parts via chemotherapy/CDT-mediated ICD, Mn2+-mediated STING activation, antibody-mediated immune checkpoint blockade. With Mn2+-endowed r1 relaxivity (1.38 mM–1 s–1), can also be MR imaging. dendrimer-mediated may developed advanced nanomedicine tackle other cancer types.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123125 - 123125
Published: Jan. 1, 2025
Language: Английский
Citations
0