International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2809 - 2809

Published: March 20, 2025

Carbon monoxide (CO) plays a multifaceted role in both physiology and pathophysiology. At high levels, it is lethal to humans due its tight binding globins cytochrome c oxidase. low doses, CO can exhibit beneficial effects; serves as an endogenous signaling molecule possesses antibacterial properties, which opens up possibilities for use antimicrobial agent. For this purpose, research progress develop metal-based CO-releasing molecules, metal-free organic prodrugs, CO-generating hydrogel microspheres. The energy metabolism of prokaryotes key point that may be targeted by kill invading pathogens. cornerstone prokaryotic series membrane-bound enzyme complexes, constitute respiratory chain. Terminal oxidases, at the end chain, contain hemes are therefore potential targets CO. However, area very early stage. impact on bacterial also provide basis biotechnological applications gas present. This review discusses molecular effects microbial growth aerobic respiration supported different terminal oxidases light recent findings.

Language: Английский