Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases DOI Creative Commons
Satoshi Kawaguchi, Bruno Moukette Moukette, Taiki Hayasaka

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2023, Volume and Issue: 10(4), P. 166 - 166

Published: April 12, 2023

Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and cardiovascular diseases (CVDs), which are a major cause of morbidity mortality. With advances RNA sequencing technology, the focus recent research has transitioned from studies specific candidates to whole transcriptome analyses. Thanks these types studies, new ncRNAs have been identified for their implication CVDs. In this review, we briefly describe classification into microRNAs, long ncRNAs, circular RNAs. We then discuss critical CVDs by citing most up-to-date articles. More specifically, summarize formation heart tube morphogenesis, mesoderm specification, embryonic cardiomyocytes progenitor cells. also highlight that recently emerged as key regulators focusing on six them. believe review concisely addresses perhaps not all but certainly aspects current progress ncRNA Thus, would be beneficial readers obtain picture mechanisms action

Language: Английский

Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions DOI Open Access
Paola Bontempo, Lucia Capasso, Luigi De Masi

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2399 - 2399

Published: July 24, 2024

Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality. These have multifaceted nature being influenced by multitude biochemical, genetic, environmental, behavioral factors. Epigenetic modifications crucial role in the onset progression CVD. Epigenetics, which regulates gene activity without altering DNA’s primary structure, can modulate cardiovascular homeostasis through DNA methylation, histone modification, non-coding RNA regulation. The effects environmental stimuli on CVD are mediated epigenetic changes, be reversible and, hence, susceptible to pharmacological interventions. This represents an opportunity prevent targeting harmful modifications. Factors such as high-fat diets or nutrient deficiencies influence enzymes, affecting fetal growth, metabolism, oxidative stress, inflammation, atherosclerosis. Recent studies shown that plant-derived bioactive compounds regulators inflammatory responses, contributing cardioprotective diets. Understanding these nutriepigenetic their reversibility is for developing effective interventions combat review delves into general mechanisms epigenetics, its regulatory roles CVD, potential epigenetics therapeutic strategy. It also examines natural (ENCs) intervention tools prevention therapy.

Language: Английский

Citations

12
The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis DOI Open Access

Qianyun Feng,

Sheng Zheng,

Jia Zheng

et al.

Bioscience Reports, Journal Year: 2018, Volume and Issue: 38(3)

Published: May 30, 2018

Osteoporosis, a common and multifactorial disease, is influenced by genetic factors environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may be underlying mechanisms link environmental with increased risks bone fracture. MicroRNA (miRNA), major category small noncoding RNA 20–22 bases in length, recognized as one important modification. It can mediate post-transcriptional regulation target genes cell differentiation apoptosis. In this review, we aimed to profile role miRNA remodeling its therapeutic implications for osteoporosis. A deeper insight into provide unique opportunities develop novel diagnostic approach

Language: Английский

Citations

83
Roles of CircRNAs in Autoimmune Diseases DOI Creative Commons
Xin Xia, Xinyi Tang, Shengjun Wang

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: April 2, 2019

Circular RNAs (circRNAs) are covalently linked single-stranded RNAs, compared to linear counterparts, that relatively abundant, conserved, stable and specific. Previously, most studies have revealed circRNAs function in gene expression processes participate the pathogenesis of cancers, cardiovascular diseases neurological diseases. With advances biotechnology, more biological functions been found several signaling pathways related tumorigenesis, immunity metabolism. Recently, many reported be expressed abnormally play important roles progression autoimmune Thus, may not only serve as potential biomarkers but also act immune regulators offer opportunities for therapy. This review briefly introduces properties well different stages expression. In addition, this article summarizes available knowledge about discusses their these diseases, which helps us understand regulatory mechanisms provides future research perspectives.

Language: Английский

Citations

74
Circulating exosomal miRNAs in cardiovascular disease pathogenesis: New emerging hopes DOI
Amirsaeed Sabeti Aghabozorgi, Najmeh Ahangari, Tasnim Eghbal Eftekhaari

et al.

Journal of Cellular Physiology, Journal Year: 2019, Volume and Issue: 234(12), P. 21796 - 21809

Published: July 5, 2019

Abstract Cardiovascular diseases (CVDs) are one of the leading causes morbidity and mortality. Standard therapies have failed to significantly increase patients’ survival. Moreover, majority conventional screening procedures ineffective for diagnosis CVDs at early stages. Accumulating evidence suggests that numerous cell types release a class nano‐sized vesicles named exosomes into extracellular space. Exosomes widely distributed in various body fluids contain number diverse biomolecules such as proteins, lipids, both mRNA noncoding RNAs which reflect host‐cell molecular architecture. MicroRNAs (miRNAs), can be found exosomes, could taken up by neighboring distal cells. Not only has recent indicated regulatory role exosomal miRNAs pathogenesis CVD, but it also been shown differential expression made them promising biomarkers detection CVDs. Owing these remarkable features, emerged hot spots research. This review summarizes discusses their potential application clinical setting therapeutic diagnostic tools.

Language: Английский

Citations

66
KCNQ1OT1, HIF1A‐AS2 and APOA1‐AS are promising novel biomarkers for diagnosis of coronary artery disease DOI
Yuan Zhang, Lei Zhang, Yu Wang

et al.

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2019, Volume and Issue: 46(7), P. 635 - 642

Published: April 3, 2019

Abstract This study aimed to evaluate the potential of long noncoding RNA s (lnc s) as biomarkers for coronary artery disease ( CAD ). We measured levels three atherosclerosis‐ or cardiac‐related lnc in peripheral blood monocyte cells PBMC from 20 patients and non‐ control participants using real‐time reverse transcription–polymerase chain reaction (real‐time RT – PCR ) methods. found that KCNQ 1 opposite strand/antisense transcript OT 1), hypoxia‐inducible factor alpha‐antisense 2 HIF 1A‐ AS 2) apolipoprotein A‐1 antisense APOA 1‐ were significantly increased by 2.38‐fold, P = 0.00042; 2.00‐fold, 0.0001; 4.52‐fold, 0.000048). The area under ROC curve was 0.865 1, 0.852 2, 0.967 . Furthermore, combination resulted a much higher AUC value 0.990 prediction Spearman's correlation analysis showed positively correlated with NT ‐pro BNP , CKMB MYO HsTnT, whereas HsTnT. Hence, elevation predicts these molecules may be considered novel

Language: Английский

Citations

59
MicroRNAs and Long Non-coding RNAs in Genetic Diseases DOI Creative Commons
Alessia Finotti, Enrica Fabbri, Ilaria Lampronti

et al.

Molecular Diagnosis & Therapy, Journal Year: 2019, Volume and Issue: 23(2), P. 155 - 171

Published: Jan. 4, 2019

Since the discovery and classification of non-coding RNAs, their roles have gained great attention. In this respect, microRNAs long RNAs been firmly demonstrated to be linked regulation gene expression onset human diseases, including rare genetic diseases; therefore they are suitable targets for therapeutic intervention. This issue, in context is being considered by an increasing number research groups key interest health community. case possibility developing personalized therapy precision medicine has attracted attention researchers clinicians involved "orphan medicinal products" proposing these European Medicines Agency (EMA) Food Drug Administration (FDA) Office Orphan Products Development (OOPD) United States. The major focuses activities evaluation development products (drugs, biologics, devices, or medical foods) promising diagnosis and/or treatment diseases conditions, diseases. analysis proven a strategy. These include, but not limited to, Duchenne muscular dystrophy, cystic fibrosis, Rett syndrome, β-thalassemia. conclusion, large approaches based on targeting expected field molecular therapy, with facilitated technological transfer virtue existing concerning

Language: Английский

Citations

58
Emerging roles of circRNAs in the pathological process of myocardial infarction DOI Creative Commons
Zeng-Jin Wen, Xin Hui, Yongchen Wang

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2021, Volume and Issue: 26, P. 828 - 848

Published: Oct. 9, 2021

Myocardial infarction (MI) is defined as cardiomyocyte death in a clinical context consistent with ischemic insult. MI remains one of the leading causes morbidity and mortality worldwide. Although there are number effective methods for diagnosis treatment MI, further investigation novel biomarkers molecular therapeutic targets required. Circular RNAs (circRNAs), non-coding RNAs, have been reported to function mainly by acting microRNA (miRNA) sponges or binding RNA-binding proteins (RBPs). The circRNA-miRNA-mRNA (protein) regulatory pathway regulates gene expression affects pathological mechanisms various diseases. Undoubtedly, more comprehensive understanding relationship between circRNA will lay foundation development circRNA-based diagnostic strategies MI. Therefore, this review summarizes pathophysiological process approaches measure levels patients, tissues, cells; highlights significance circRNAs regulation pathogenesis development; provides potential insight diagnosis, prognosis,

Language: Английский

Citations

46
Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview DOI Creative Commons
Fakhara Sabir, Mahmood Barani, Mahwash Mukhtar

et al.

Chemosensors, Journal Year: 2021, Volume and Issue: 9(4), P. 67 - 67

Published: March 30, 2021

Cardiovascular diseases (CVDs) are the world’s leading cause of mortality and represent a large contributor to costs medical care. Although tremendous progress has been made for diagnosis CVDs, there is an important need more effective early design novel diagnostic methods. The CVDs generally relies on signs symptoms depending molecular imaging (MI) or CVD-associated biomarkers. For early-stage however, reliability, specificity, accuracy analysis still problematic. Because their unique chemical physical properties, nanomaterial systems have recognized as potential candidates enhance functional use instruments. Nanomaterials such gold nanoparticles, carbon nanotubes, quantum dots, lipids, polymeric nanoparticles sources target CVDs. special properties nanomaterials including surface energy topographies actively cellular response within availability newly advanced techniques in science opens new avenues targeting successful application needs detailed understanding both disease moieties.

Language: Английский

Citations

42
Epigenetics-based therapeutics for myocardial fibrosis DOI
Xuping Li, Ying Yang, Sixuan Chen

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 271, P. 119186 - 119186

Published: Feb. 9, 2021

Language: Английский

Citations

41
circCELF1 Inhibits Myocardial Fibrosis by Regulating the Expression of DKK2 Through FTO/m6A and miR-636 DOI
Xuexun Li,

Bin Mu,

Xi Li

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2022, Volume and Issue: 15(5), P. 998 - 1009

Published: Feb. 7, 2022

Language: Английский

Citations

36