Reactive Astrocytes: Production, Function, and Therapeutic Potential

Immunity, Journal Year: 2017, Volume and Issue: 46(6), P. 957 - 967

Published: June 1, 2017

Language: Английский

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Reactive astrocyte nomenclature, definitions, and future directions

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(3), P. 312 - 325

Published: Feb. 15, 2021

Language: Английский

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How neuroinflammation contributes to neurodegeneration

Science, Journal Year: 2016, Volume and Issue: 353(6301), P. 777 - 783

Published: Aug. 18, 2016

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most pressing problems of developed societies with aging populations. Neurons carry out essential functions signal transmission network integration in central nervous system main targets neurodegenerative disease. In this Review, I address how neuron's environment also contributes to neurodegeneration. Maintaining an optimal milieu for neuronal function rests supportive cells termed glia blood-brain barrier. Accumulating evidence suggests that neurodegeneration occurs part because is affected during disease a cascade processes collectively neuroinflammation. These observations indicate therapies targeting glial might provide benefit those afflicted by disorders.

Language: Английский

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Astrocyte scar formation aids central nervous system axon regeneration

Nature, Journal Year: 2016, Volume and Issue: 532(7598), P. 195 - 200

Published: March 29, 2016

Language: Английский

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The Microenvironmental Landscape of Brain Tumors

Cancer Cell, Journal Year: 2017, Volume and Issue: 31(3), P. 326 - 341

Published: March 1, 2017

Language: Английский

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Establishment and Dysfunction of the Blood-Brain Barrier

Cell, Journal Year: 2015, Volume and Issue: 163(5), P. 1064 - 1078

Published: Nov. 1, 2015

Language: Английский

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Physiology of Astroglia

Physiological Reviews, Journal Year: 2017, Volume and Issue: 98(1), P. 239 - 389

Published: Dec. 24, 2017

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense the central nervous system (CNS). highly heterogeneous in morphological appearance; they express a multitude receptors, channels, membrane transporters. This complement underlies their remarkable adaptive plasticity defines functional maintenance CNS development aging. tightly integrated into networks act within context tissue; astrocytes control at all levels organization from molecular to whole organ.

Language: Английский

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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Nature Medicine, Journal Year: 2016, Volume and Issue: 22(6), P. 586 - 597

Published: May 9, 2016

Language: Английский

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Diversity of astrocyte functions and phenotypes in neural circuits

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(7), P. 942 - 952

Published: June 25, 2015

Language: Английский

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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(7), P. 419 - 434

Published: May 18, 2017

Language: Английский

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