Nutrients,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3631 - 3631
Published: Oct. 25, 2024
Impaired
cognition
is
a
key
trait
of
the
diseases
aging
and
an
important
quality
life
factor
for
older
adults
their
families.
Over
past
decade,
there
has
been
increasing
appreciation
role
microbiome
in
cognition,
as
well
emerging
evidence
that
probiotics,
such
those
yogurt
other
dairy
products,
can
have
positive
impact
on
cognitive
function.
However,
it
unclear
to
what
extent
consumption
associated
with
improved
function
adults.
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(6), P. 558 - 558
Published: May 30, 2024
Mood
disorders
and
substance
use
disorder
(SUD)
are
of
immense
medical
social
concern.
Although
significant
progress
on
neuronal
involvement
in
mood
reward
circuitries
has
been
achieved,
it
is
only
relatively
recently
that
the
role
glia
these
attracted
attention.
Detailed
understanding
glial
functions
devastating
diseases
could
offer
novel
interventions.
Here,
following
a
brief
review
involved
regulation
perception,
specific
contributions
neurotrophic
factors,
neuroinflammation,
gut
microbiota
to
highlighted.
In
this
context,
cells
(e.g.,
microglia,
astroglia,
oligodendrocytes,
synantocytes)
phenotypic
manifestation
or
SUD
emphasized.
addition,
knowledge
potential
development
therapeutics
touched
upon.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Aging
is
associated
with
disrupted
sleep
patterns,
such
as
fragmented
and
reduced
efficiency,
leading
to
negative
health
outcomes.
There
evidence
of
a
bidirectional
relationship
between
gut
microbiota,
which
plays
key
role
in
the
gut-brain
axis
overall
health.
However,
studies
on
this
older
adults
have
limited
generalizability
show
conflicting
results,
highlighting
need
for
further
research.
This
study
aimed
investigate
associations
quality
microbiota
composition
healthy
Chinese
using
subjective
objective
measures
capture
various
aspects
explore
potential
impacts
emotional
well-being
cognitive
performance.
Subjective
was
assessed
Pittsburgh
Sleep
Quality
Index
(PSQI)
questionnaire,
while
measured
actigraphy.
Gut
sequencing
performed
stool
samples.
The
results
robust
positive
association
richness
adults,
independent
demographics,
lifestyle,
covariates.
no
significant
link
found
quality.
Specific
taxa
like
Bacteroidetes,
Ruminococcus,
Collinsella,
Veillonella,
Holdemania
were
tentatively
linked
These
findings
emphasize
connection
research
clinical
implications,
improving
our
understanding
mechanisms
underlying
sleep-gut
guiding
development
interventions
both
adults.
Genes,
Journal Year:
2024,
Volume and Issue:
15(10), P. 1263 - 1263
Published: Sept. 27, 2024
:
A
growing
body
of
research
supports
the
role
microbial
communities
residing
in
digestive
system
host's
cognitive
functioning.
Most
these
studies
have
been
focused
on
gut
microbiome
and
its
association
with
clinical
phenotypes
middle-aged
older
adults.
There
is
an
insufficiency
population-based
exploring
normative
functioning
particularly
oral
microbiota.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 26, 2024
The
gut-brain-metabolic
axis
has
emerged
as
a
critical
area
of
research,
highlighting
the
intricate
connections
between
gut
microbiome,
metabolic
processes,
and
cognitive
function.
This
review
article
delves
into
complex
interplay
these
interconnected
systems,
exploring
their
role
in
development
insulin
resistance
decline.
emphasizes
pivotal
influence
microbiota
on
central
nervous
system
(CNS)
function,
demonstrating
how
microbial
colonization
can
program
hypothalamic-pituitary-adrenal
(HPA)
for
stress
response
mice.
It
further
elucidates
mechanisms
by
which
carbohydrate
metabolism
contributes
to
resistance,
key
factor
pathogenesis
disorders
impairment.
Notably,
highlights
therapeutic
potential
targeting
through
various
interventions,
such
dietary
modifications,
probiotics,
prebiotics,
fecal
transplantation
(FMT).
These
approaches
have
shown
promising
results
improving
sensitivity
function
both
animal
models
human
studies.
also
need
research
elucidate
specific
species
metabolites
involved
modulating
gut-brain
axis,
well
long-term
effects
safety
interventions.
Advances
metagenomics,
metabolomics,
bioinformatics
are
expected
provide
deeper
insights
interactions
within
impact
host
health.
Overall,
this
comprehensive
underscores
significance
treatment
disorders,
offering
avenue
novel
strategies
system.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Mental
health
is
a
serious
issue,
with
mental
disorders
affecting
millions
of
people
globally.
Gut
microbiota
has
received
considerable
attention
because
its
potential
role
in
the
pathogenesis
disorders.
This
systematic
review
synthesized
15
studies
exploring
effects
gut
microbiome
on
depression,
anxiety,
schizophrenia,
and
bipolar
disorder,
qualitative
quantitative
insights.
The
were
conducted
different
countries
employed
various
methods
including
16S
rRNA
sequencing
metagenomic
analysis
sample
sizes
varying
from
50
to
600.
Some
key
findings
that
depression
was
associated
reduced
microbial
diversity
high
levels
Firmicutes,
anxiety
low
short-chain
fatty
acid
(SCFA)-producing
bacteria
Proteobacteria.
Schizophrenia
related
endotoxemia
reduction
Lactobacillus
count
whereas
disorder
displayed
shift
Firmicutes/Bacteroidetes
ratio.
Of
interest,
probiotics
dietary
changes
as
effective
drug
treatment
leading
symptom
alleviation
many
patients.
It
found
linked
less
diverse
while
an
increase
inflammatory
bacteria.
People
also
have
patterns.
emphasizes
importance
pathophysiology
promising
value
targeting
microbiomes
pharmacological
approaches.
Molecular Medicine Reports,
Journal Year:
2025,
Volume and Issue:
32(2), P. 1 - 21
Published: June 3, 2025
Postoperative
delirium
(POD)
is
a
common
postoperative
complication,
characterized
by
acute,
transient
and
fluctuating
declines
in
consciousness
attention,
with
an
incidence
that
increases
age.
POD
associated
various
adverse
outcomes,
including
prolonged
hospital
stays,
higher
medical
costs
increased
morbidity
mortality
rates.
Moreover,
it
has
been
suggested
POD,
as
early
manifestation
of
cognitive
impairment,
may
serve
precursor
to
long‑term
dysfunction.
Given
its
considerable
clinical
impact,
the
prevention
management
are
critical
importance.
However,
mechanisms
underlying
remain
insufficiently
understood.
Current
hypotheses
primarily
implicate
neuroinflammation,
oxidative
stress,
neurotransmitter
dysregulation
pathological
protein
changes,
such
β‑amyloid
deposition
tau
hyperphosphorylation.
Disruptions
sleep‑wake
cycle,
electroencephalographic
burst
suppression,
microbiota‑gut‑brain
axis,
olfactory‑brain
axis
genetic
susceptibility
also
contribute
occurrence.
Multiple
signaling
pathways
involved
Wnt/β‑catenin,
PI3K/AKT,
brain‑derived
neurotrophic
factor/tropomyosin
receptor
kinase
B,
toll‑like
NF‑κB
pathways.
These
findings
not
only
elucidate
potential
but
highlight
essential
therapeutic
targets
theoretical
foundations
for
management.
due
complexity
multifactorial
nature
pathogenesis
no
comprehensive
or
widely
accepted
measures
have
yet
established
treatment.
Both
non‑pharmacological
pharmacological
interventions
role
Non‑pharmacological
strategies
currently
prioritized,
training,
Hospital
Elder
Life
Program
geriatric
assessment.
Pharmacological
include
dexmedetomidine,
melatonin
non‑steroidal
anti‑inflammatory
drugs,
intranasal
insulin
emerging
promising
preventive
approach.
Additionally,
anesthesia
strategies,
depth
monitoring,
blood
pressure
regulation
multimodal
analgesia,
recognized
effective
reducing
risk
POD.
The
present
review
provides
overview
relevant
available
strategies.
By
deepening
understanding
aims
offer
practical
guidance
clinicians
optimizing
approaches.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 8, 2024
Abstract
Visceral
rhythms
orchestrate
the
physiological
states
underlying
human
emotion.
Chronic
aberrations
in
these
brain-body
interactions
are
implicated
a
broad
spectrum
of
mental
health
disorders.
However,
specific
contributions
gastric-brain
coupling
to
affective
symptoms
remain
poorly
understood.
We
investigated
relationship
between
this
novel
interoceptive
axis
and
243
participants,
using
cross
validated
machine
learning
approach.
find
that
frontal
parietal
brain
gastric
rhythm
indexes
dimensional
signature
spanning
anxiety,
depression,
stress,
well-being.
Control
analyses
confirm
specificity
axis.
Our
study
establishes
stomach
as
factor
pathology
health,
offers
new
targets
for
interventions
remediating
aberrant
coupling.
