The Impact of Physical Activity on the Circadian System: Benefits for Health, Performance and Wellbeing DOI Creative Commons

Dietmar Weinert,

Denis Gubin

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(18), P. 9220 - 9220

Published: Sept. 14, 2022

Circadian rhythms are an inherent property of all living systems and essential part the external internal temporal order. They enable organisms to be synchronized with their periodic environment guarantee optimal functioning organisms. Any disturbances, so-called circadian disruptions, may have adverse consequences for health, physical mental performance, wellbeing. The environmental light–dark cycle is main zeitgeber rhythms. Moreover, regular activity most useful. Not only does it general favorable effects on cardiovascular system, energy metabolism example, but also stabilize system via feedback suprachiasmatic nuclei (SCN), pacemaker. Regular helps maintain high-amplitude rhythms, particularly clock gene expression in SCN. It promotes entrainment periodicities improves synchronization various This turn health In experiments Djungarian hamsters, voluntary access a running wheel not stabilized rhythm, intensive even reestablished rhythm arrhythmic individuals. cognitive abilities were restored. hamsters phenotype which SCN do generate signal diminished social memory compromised. Voluntary restored these simultaneously reestablishment rhythm. Intensively exercising Syrian less anxious, more resilient defeat, show defensive/submissive behaviors, i.e., exercise promote self-confidence. Similar described humans. aim present paper summarize current knowledge concerning stability corresponding performance.

Language: Английский

Epigenetic regulation of aging: implications for interventions of aging and diseases DOI Creative Commons
Wang Kang, Huicong Liu, Qinchao Hu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 7, 2022

Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy

Language: Английский

Citations

335
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice DOI
Victoria A. Acosta-Rodríguez, Filipa Rijo‐Ferreira,

Mariko Izumo

et al.

Science, Journal Year: 2022, Volume and Issue: 376(6598), P. 1192 - 1202

Published: May 5, 2022

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising question if is calories, or time day that cause this increased span. We show here 30% CR was sufficient to extend span 10%; however, a daily fasting interval circadian alignment acted together 35% in male C57BL/6J mice. These effects were independent body weight. Aging induced widespread increases gene expression associated with inflammation decreases genes encoding components metabolic pathways liver from ad libitum-fed at night ameliorated these aging-related changes. Our results interventions promote longevity provide perspective further explore aging.

Language: Английский

Citations

260
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

213
Making sense of the ageing methylome DOI
Kirsten Seale, Steve Horvath, Andrew E. Teschendorff

et al.

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(10), P. 585 - 605

Published: May 2, 2022

Language: Английский

Citations

177
Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans DOI
Lorenzo Figà Talamanca, Cédric Gobet, Félix Naef

et al.

Science, Journal Year: 2023, Volume and Issue: 379(6631), P. 478 - 483

Published: Feb. 2, 2023

The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age sex is not defined in humans. We combined data from Genotype-Tissue Expression (GTEx) project with an algorithm that assigns phases to 914 donors, by integrating temporal information multiple tissues each individual, identify messenger RNA (mRNA) 46 tissues. Clock transcripts showed conserved timing relationships tight synchrony across body. mRNA varied breadth, covering global functions, including metabolic pathways systemic responses. structure was sexes groups. overall were highly sex-dimorphic more sustained females. Rhythmic programs generally dampened

Language: Английский

Citations

106
Defining the age-dependent and tissue-specific circadian transcriptome in male mice DOI Creative Commons
Christopher A. Wolff, Miguel A. Gutierrez‐Monreal, Lingsong Meng

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(1), P. 111982 - 111982

Published: Jan. 1, 2023

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in functions. To define age-dependent at the systems level, we profile transcriptome hypothalamus, lung, heart, kidney, skeletal muscle, adrenal gland three age groups. We find tissue-specific clock output changes. Aging reduces number of rhythmically expressed genes (REGs), indicative weakened control. REGs are enriched for hallmarks aging, adding another dimension to our understanding aging. Analyzing differential gene expression within tissue four different times day identifies distinct clusters differentially (DEGs). Increased variability across is common feature aged tissues. This analysis extends landscape aging highlights impact on function temporal expression.

Language: Английский

Citations

95
Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study DOI Creative Commons
Hongliang Feng, Lulu Yang, Yannis Yan Liang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 18, 2023

There is a growing interest in the role of timing daily behaviors improving health. However, little known about optimal physical activity to maximize health benefits. We perform cohort study 92,139 UK Biobank participants with valid accelerometer data and all-cause cause-specific mortality outcomes, comprising over 7 years median follow-up (638,825 person-years). Moderate-to-vigorous intensity (MVPA) at any time day associated lower risks for all-cause, cardiovascular disease, cancer mortality. In addition, compared morning group (>50% MVPA during 05:00-11:00), midday-afternoon (11:00-17:00) mixed groups, but not evening (17:00-24:00), have disease These protective associations are more pronounced among elderly, males, less physically active participants, or those preexisting diseases. Here, we show that may potential improve public

Language: Английский

Citations

88
DNA methylation networks underlying mammalian traits DOI
Amin Haghani, Caesar Z. Li, Todd R. Robeck

et al.

Science, Journal Year: 2023, Volume and Issue: 381(6658)

Published: Aug. 10, 2023

Using DNA methylation profiles (

Language: Английский

Citations

87
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases DOI Creative Commons

Shuaifei Ji,

Mingchen Xiong,

Huating Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Language: Английский

Citations

85
Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals DOI Creative Commons
Shaunak Deota, Terry Lin, Amandine Chaix

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(1), P. 150 - 165.e4

Published: Jan. 1, 2023

Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of and fasting. In both animals humans, TRF has pleiotropic health benefits arise from multiple organ systems, yet the molecular basis TRF-mediated not well understood. Here, we subjected mice to isocaloric ad libitum (ALF) or western diet examined gene expression changes in samples taken 22 organs brain regions collected every 2 h over 24-h period. We discovered profoundly impacts expression. Nearly 80% all genes show differential rhythmicity under at least one tissue. Functional annotation these revealed tissue- pathway-specific TRF. These findings resources provide critical foundation for future mechanistic studies will help guide human time-restricted eating (TRE) interventions treat various disease conditions with without pharmacotherapies.

Language: Английский

Citations

72