Lewis Acid-Mediated Deoxygenative Synthesis of Trivalent Sterically Hindered Phosphines from Aldehydes DOI
Xiaoqiang Wu,

Abuduwaili Alimu,

Wei Zhong

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

The efficient synthesis of trisubstituted trivalent phosphines remains challenging. Herein, we report a novel approach for rapid construction these compounds from aldehydes under Lewis acid-mediated conditions. By using sterically hindered disubstituted phosphines, can undergo deoxygenative reaction to afford phosphorus compounds. This modular and practical method is characterized by operational simplicity, broad substrate scope, excellent functional group tolerance, which holds great potential applications in organic synthesis.

Language: Английский

Lewis Acid-Mediated Deoxygenative Synthesis of Trivalent Sterically Hindered Phosphines from Aldehydes DOI
Xiaoqiang Wu,

Abuduwaili Alimu,

Wei Zhong

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

The efficient synthesis of trisubstituted trivalent phosphines remains challenging. Herein, we report a novel approach for rapid construction these compounds from aldehydes under Lewis acid-mediated conditions. By using sterically hindered disubstituted phosphines, can undergo deoxygenative reaction to afford phosphorus compounds. This modular and practical method is characterized by operational simplicity, broad substrate scope, excellent functional group tolerance, which holds great potential applications in organic synthesis.

Language: Английский

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