Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
Colorectal
cancer
(CRC)
usually
creates
an
immunosuppressive
microenvironment,
thereby
hindering
immunotherapy
response.
Effective
treatment
options
remain
elusive.
Using
scRNA‐seq
analysis
in
a
tumor‐bearing
murine
model,
it
is
found
that
lobeline,
alkaloid
from
the
herbal
medicine
lobelia,
promotes
polarization
of
tumor‐associated
macrophages
(TAMs)
toward
M1‐like
TAMs
while
inhibiting
their
M2‐like
TAMs.
Additionally,
lobeline
upregulates
mRNA
expression
secreted
Ly‐6/UPAR‐related
protein
1
(
Slurp1
)
cells.
The
inhibitory
effects
on
tumor
load
and
TAM
are
almost
completely
eliminated
when
Slurp1‐deficient
MC38
cells
subcutaneously
injected
into
mice,
suggesting
exerts
antitumor
effect
Slurp1‐dependent
manner.
Furthermore,
using
target‐responsive
accessibility
profiling,
MAPK14
identified
as
direct
target
lobeline.
Mechanistically,
upon
binding
to
colon
cells,
prevents
nuclear
translocation
MAPK14,
resulting
decreased
levels
phosphorylated
p53.
Consequently,
negative
transcriptional
regulation
SLURP1
by
p53
suppressed,
leading
enhanced
transcription
secretion
SLURP1.
Finally,
combination
therapy
anti‐PD1
exhibits
stronger
effects.
Taken
together,
these
findings
suggest
remodeling
microenvironment
small‐molecule
may
represent
promising
therapeutic
strategy
for
CRC.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Sept. 1, 2022
Abstract
The
current
understanding
of
lactate
extends
from
its
origins
as
a
byproduct
glycolysis
to
role
in
tumor
metabolism,
identified
by
studies
on
the
Warburg
effect.
shuttle
hypothesis
suggests
that
plays
an
important
bridging
signaling
molecule
coordinates
among
different
cells,
organs
and
tissues.
Lactylation
is
posttranslational
modification
initially
reported
Professor
Yingming
Zhao’s
research
group
2019.
Subsequent
confirmed
lactylation
vital
component
function
involved
proliferation,
neural
excitation,
inflammation
other
biological
processes.
An
indispensable
substance
for
various
physiological
cellular
functions,
regulatory
aspects
energy
metabolism
signal
transduction.
Therefore,
comprehensive
review
summary
presented
clarify
disease
provide
reference
direction
future
research.
This
offers
systematic
overview
homeostasis
roles
pathological
processes,
well
effects
diseases,
particularly
cancer.
Cell,
Journal Year:
2023,
Volume and Issue:
186(19), P. 4007 - 4037
Published: Sept. 1, 2023
The
TGF-β
regulatory
system
plays
crucial
roles
in
the
preservation
of
organismal
integrity.
signaling
controls
metazoan
embryo
development,
tissue
homeostasis,
and
injury
repair
through
coordinated
effects
on
cell
proliferation,
phenotypic
plasticity,
migration,
metabolic
adaptation,
immune
surveillance
multiple
types
shared
ecosystems.
Defects
signaling,
particularly
epithelial
cells,
fibroblasts,
disrupt
tolerance,
promote
inflammation,
underlie
pathogenesis
fibrosis
cancer,
contribute
to
resistance
these
diseases
treatment.
Here,
we
review
how
coordinates
multicellular
response
programs
health
disease
this
knowledge
can
be
leveraged
develop
treatments
for
system.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(23)
Published: June 1, 2023
Colorectal
cancer
(CRC)
is
the
most
common
of
digestive
system
with
high
mortality
and
morbidity
rates.
Gut
microbiota
found
in
intestines,
especially
colorectum,
has
structured
crosstalk
interactions
host
that
affect
several
physiological
processes.
The
gut
include
CRC-promoting
bacterial
species,
such
as
Fusobacterium
nucleatum,
Escherichia
coli,
Bacteroides
fragilis,
CRC-protecting
Clostridium
butyricum,
Streptococcus
thermophilus,
Lacticaseibacillus
paracasei,
which
along
other
microorganisms,
viruses
fungi,
play
critical
roles
development
CRC.
Different
features
are
identified
patients
early-onset
CRC,
combined
different
patterns
between
fecal
intratumoral
microbiota.
may
be
beneficial
diagnosis
treatment
CRC;
some
bacteria
serve
biomarkers
while
others
regulators
chemotherapy
immunotherapy.
Furthermore,
metabolites
produced
by
essential
CRC
cells.
Harmful
primary
bile
acids
short-chain
fatty
acids,
whereas
others,
including
ursodeoxycholic
acid
butyrate,
impede
tumor
progression.
This
review
focuses
on
its
metabolites,
their
potential
development,
diagnosis,
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 901 - 901
Published: April 9, 2023
Colorectal
cancer
(CRC)
represents
the
second
leading
cause
of
cancer-related
deaths
worldwide.
The
pathogenesis
CRC
is
a
complex
multistep
process.
Among
other
factors,
inflammation
and
oxidative
stress
(OS)
have
been
reported
to
be
involved
in
initiation
development
CRC.
Although
OS
plays
vital
part
life
all
organisms,
its
long-term
effects
on
human
body
may
different
chronic
diseases,
including
diseases.
Chronic
can
lead
oxidation
biomolecules
(nucleic
acids,
lipids
proteins)
or
activation
inflammatory
signaling
pathways,
resulting
several
transcription
factors
dysregulation
gene
protein
expression
followed
by
tumor
cell
survival.
In
addition,
it
well
known
that
intestinal
diseases
such
as
bowel
disease
(IBD)
are
associated
with
an
increased
risk
cancer,
link
between
IBD
progression
has
reported.
This
review
focuses
role
causative
agent
colorectal
cancer.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 115015 - 115015
Published: June 15, 2023
Among
the
most
extensively
researched
processes
in
development
and
treatment
of
cancer
is
inflammatory
condition.
Although
acute
inflammation
essential
for
wound
healing
reconstruction
tissues
that
have
been
damaged,
chronic
may
contribute
to
onset
growth
a
number
diseases,
including
cancer.
By
disrupting
signaling
cells,
which
result
induction,
invasion,
development,
variety
molecules
are
linked
The
microenvironment
surrounding
tumor
greatly
influenced
by
cells
their
subsequent
secretions,
also
significantly
tumor's
growth,
survivability,
potential
migration.
These
variables
mentioned
several
publications
as
prospective
diagnostic
tools
anticipating
Targeting
with
various
therapies
can
reduce
response
potentially
limit
or
block
proliferation
cells.
scientific
medical
literature
from
past
three
decades
has
studied
determine
how
chemicals
cell
pathways
related
invasion
metastasis
related.
current
narrative
review
updates
relevant
while
highlighting
specifics
possible
therapeutic
possibilities.
Cancer Communications,
Journal Year:
2022,
Volume and Issue:
42(12), P. 1347 - 1366
Published: Oct. 8, 2022
Abstract
Background
N‐acetyltransferase
10
(
NAT10
)
is
the
only
enzyme
known
to
mediate
N4‐acetylcytidine
(ac4C)
modification
of
mRNA
and
crucial
for
stability
translation
efficiency.
However,
its
role
in
cancer
development
prognosis
has
not
yet
been
explored.
This
study
aimed
examine
possible
colon
cancer.
Methods
The
expression
levels
were
evaluated
by
immunohistochemical
analyses
with
a
tissue
microarray,
prognostic
value
patients
was
further
analyzed.
Quantitative
real‐time
polymerase
chain
reaction
(qRT‐PCR)
Western
blotting
performed
analyze
harvested
tissues
cell
lines.
Stable
‐knockdown
‐overexpressing
lines
constructed
using
lentivirus.
biological
functions
analyzed
vitro
Cell
Counting
Kit‐8
(CCK‐8),
wound
healing,
Transwell,
cycle,
ferroptosis
assays.
Xenograft
models
used
effect
on
tumorigenesis
metastasis
cells
vivo.
Dot
blotting,
acetylated
RNA
immunoprecipitation‐qPCR,
explore
mechanism
which
progression.
Results
upregulated
various
increased
associated
shorter
patient
survival.
Knockdown
two
(HT‐29
LoVo)
impaired
proliferation,
migration,
invasion,
tumor
formation
these
cells,
whereas
overexpression
promoted
abilities.
Further
analysis
revealed
that
exerted
strong
suppressor
protein
1
FSP1
HT‐29
LoVo
cells.
In
found
be
modified
ac4C
acetylation,
this
epigenetic
inhibition
ferroptosis.
Conclusions
Our
plays
critical
affecting
ferroptosis,
suggesting
could
novel
therapeutic
target
