Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 29, 2025
Direct
chemiluminescence
(CL)
detection
requires
a
proper
luminophore
to
emit
light
through
nonenzymatic
activation.
Herein,
we
synthesized
new
class
of
3-aminophthalhydrazide-type
luminophores
(LM-1-LM-13)
with
intensive
CL
emission.
A
typical
analogue
LM-5
was
studied
in
detail,
which
exhibits
greatly
improved
properties
and
enhanced
storage
stability
compared
the
widely
used
N-(4-aminobutyl)-N-ethylisoluminol
(ABEI).
The
result
magnetic
bead-based
reveals
that
holds
great
potential
become
next-generation
biosensing
applications.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 5927 - 5939
Published: Feb. 21, 2024
Deep-tissue
optical
imaging
and
photodynamic
therapy
(PDT)
remain
a
big
challenge
for
the
diagnosis
treatment
of
cancer.
Chemiluminescence
(CL)
has
emerged
as
promising
tool
biological
in
vivo
therapy.
The
development
covalent-binding
chemiluminescence
agents
with
high
stability
resonance
energy
transfer
(CRET)
efficiency
is
urgent.
Herein,
we
design
synthesize
an
unprecedented
chemiluminescent
conjugated
polymer
PFV-Luminol,
which
consists
polyfluorene
vinylene
(PFV)
main
chains
isoluminol-modified
side
chains.
Notably,
isoluminol
groups
ability
are
covalently
linked
to
by
amide
bonds,
dramatically
narrow
their
distance,
greatly
improving
CRET
efficiency.
In
presence
pathologically
levels
various
reactive
oxygen
species
(ROS),
especially
singlet
(
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(21)
Published: March 19, 2024
Abstract
Advancing
the
development
of
point‐of‐care
testing
(POCT)
sensors
that
utilize
interstitial
fluid
(ISF)
presents
considerable
obstacles
in
terms
rapid
sampling
and
analysis.
Herein,
an
innovative
strategy
is
introduced
involves
use
a
3D‐printed,
hollow
microneedle
array
patch
(MAP),
tandem
with
vacuum
tube
(VT)
connected
through
hose,
to
improve
ISF
extraction
efficiency
facilitate
expedited
The
employment
negative
pressure
by
VT
allows
MAP
device
effectively
gather
≈18
µL
from
dermis
live
rabbit
ear
within
concise
period
5
min.
This
methodology
enables
immediate
minimally
invasive
measurement
glucose
levels
body,
employing
personal
healthcare
meters
for
quantification.
fusion
technologies
provides
their
effortless
integration
into
comprehensive
mobile
system
analysis,
accomplished
preloading
hose
custom
sensing
papers
designed
detect
specific
analytes.
Moreover,
design
functionality
this
integrated
VT‐MAP
are
intuitively
user‐friendly,
eliminating
requirement
specialized
medical
expertise.
feature
enhances
its
potential
make
significant
impact
on
field
decentralized
healthcare.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(8), P. 5263 - 5273
Published: Feb. 16, 2024
Identification
and
characterization
of
bacterial
species
in
clinical
industrial
settings
necessitate
the
use
diverse,
labor-intensive,
time-consuming
protocols
as
well
utilization
expensive
high-maintenance
equipment.
Furthermore,
while
cutting-edge
identification
technologies
such
mass
spectrometry
PCR
are
highly
effective
identifying
pathogens,
they
fall
short
providing
additional
information
for
bacteria
not
present
databases
upon
which
these
methods
rely.
In
response
to
challenges,
we
a
robust
general
approach
based
on
their
unique
enzymatic
activity
profiles.
This
method
delivers
results
within
90
min,
utilizing
an
array
sensitive
enzyme-selective
chemiluminescent
probes.
Leveraging
our
recently
developed
technology
luminophores,
emit
light
under
physiological
conditions,
have
crafted
probes
designed
rapidly
detect
various
activities.
The
includes
detecting
resistance
important
large
class
β-lactam
antibiotics.
analysis
fingerprints
from
diverse
range
prominent
pathogens
unveiled
distinct
profiles
each
strain.
reported
universally
applicable
procedure
offers
expeditious
means
delineate
fingerprints.
opens
new
avenues
characterizing
research,
clinical,
applications.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(21)
Published: March 25, 2024
Tumor-associated
macrophages
(TAMs)
play
a
role
in
both
pro-
and
anti-tumor
functions;
the
targeted
polarization
from
M2
to
M1
TAMs
has
become
an
effective
therapy
option.
Although
detection
of
is
imperative
assess
cancer
immunotherapeutic
efficacy,
existing
optical
probes
suffer
shallow
tissue
penetration
depth
poor
specificity
toward
TAMs.
Herein,
we
report
tandem-locked
NIR
chemiluminescent
(CL)
probe
for
specific
Through
combined
molecular
engineering
approach
via
atomic
alternation
introduction
electron-withdrawing
groups,
near-infrared
(NIR)
chemiluminophores
are
screened
out
possess
record-long
emission
(over
800
nm),
record-high
CL
quantum
yield
(2.7
%
einstein/mol),
prolonged
half-life
(7.7
h).
Based
on
ideal
chemiluminophore,
(DPD
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 2, 2025
Chemiluminescence
(CL)
is
a
self-illuminating
phenomenon
fueled
by
chemical
energy
instead
of
extra
excited
light,
which
features
superiority
in
sensitivity,
signal-to-background
ratios,
and
imaging
depth.
Strategies
to
synthesize
CL
emission
unimolecular
skeleton
the
second
near-infrared
window
(NIR-II)
probe
with
direct
duplex
NIR-II
[CL/fluorescence
(FL)]
are
lacking.
Here,
we
employ
modular
synthesis
routes
construct
series
directly
activated
probes
maximum
wavelength
up
1060
nm,
use
them
for
real-time
continuous
detection
superoxide
anion
generated
acetaminophen
induced
liver
injury
female
mice
model
under
both
FL
channels.
Thus,
this
study
establishes
activatable
skeleton,
validating
scalability
CL/FL
platform
bioactive
molecule
disease
diagnosis.
chemiluminescence
authors
NIRII
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
ABSTRACT
Compared
to
fluorescence
imaging,
chemiluminescence
imaging
does
not
need
external
excitation
light,
and
hence
presents
high
depth
signal‐to‐noise
ratio
without
autofluorescence
phototoxicity,
making
it
a
promising
tool
for
biological
detection
analysis.
However,
the
target‐specific
activatable
near‐infrared
emission
chemiluminescent
probes
still
be
developed
precise
diagnosis
of
diseases.
In
this
paper,
we
synthesized
four
direct
Schaap's
chemiluminophores
(AINCL,
AIFCL,
ABTCL,
APYCL)
by
incorporating
different
electronic
acceptors,
respectively,
studied
effect
acceptors
on
optical
properties
chemiluminophores.
To
achieve
specific
hydrogen
sulfide
(H
2
S)‐related
diseases,
used
H
S‐cleavable
2,4‐dinitrophenylsulfonate
cage
phenol
groups
in
It
was
demonstrated
that
endogenous
S
inflammations
tumors
could
activate
effectively
with
specificity,
which
provided
location
nidus
allowed
us
perform
surgical
resection.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(6)
Published: Oct. 19, 2023
Abstract
Activatable
fluorescent
and
chemiluminescent
dyes
with
near‐infrared
emission
have
indispensable
roles
in
the
fields
of
bioimaging,
molecular
prodrugs,
phototheranostic
agents.
As
one
most
popular
fluorophore
scaffolds,
dicyanomethylene‐4
H
‐pyran
scaffold
has
been
applied
to
fabricate
a
large
number
versatile
activatable
optical
for
analytes
detection
diseases
diagnosis
treatment
by
virtue
its
high
photostability,
Stokes
shift,
considerable
two‐photon
absorption
cross‐section,
structural
modifiability.
This
review
discusses
design
strategies,
recognition
mechanisms,
both
vitro
vivo
bio‐applications
(especially
therapy
tumors)
dyes.
The
final
section
describes
current
shortcomings
future
development
prospects
this
topic.
