Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(19), P. 6024 - 6045

Published: Jan. 1, 2017

Progress on the design of diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems is summarized.

Language: Английский

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pH‐Responsive Polymer Nanoparticles for Drug Delivery

Macromolecular Rapid Communications, Journal Year: 2019, Volume and Issue: 40(10)

Published: March 5, 2019

Abstract Stimuli‐responsive nanoparticles have the potential to improve delivery of therapeutics a specific cell or region within body. There are many stimuli that shown for release cargo, including variation pH, redox potential, presence enzymes. pH has generated significant interest synthesis stimuli‐responsive because internalized into cells via vesicles acidified. Additionally, tumor microenvironment is known lower than surrounding tissue. In this review, different strategies design pH‐responsive discussed, focusing on use charge‐shifting polymers, acid labile linkages, and crosslinking.

Language: Английский

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Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

Nano Letters, Journal Year: 2016, Volume and Issue: 16(9), P. 5401 - 5408

Published: Aug. 4, 2016

Chemotherapeutic efficacy can be greatly improved by developing nanoparticulate drug delivery systems (nano-DDS) with high loading capacity and smart stimulus-triggered release in tumor cells. Herein, we report a novel redox dual-responsive prodrug-nanosystem self-assembled hydrophobic small-molecule conjugates of paclitaxel (PTX) oleic acid (OA). Thioether linked (PTX-S-OA) dithioether inserted (PTX-2S-OA) are designed to respond the redox-heterogeneity tumor. Dithioether has been reported show dual-responsiveness, but find that PTX-S-OA exhibits superior sensitivity over PTX-2S-OA, achieving more rapid selective free PTX from prodrug nanoassemblies triggered stimuli. PEGylated nanoassemblies, impressively (57.4%), exhibit potent antitumor activity human epidermoid carcinoma xenograft. This addresses concerns related low inefficient prodrugs PTX, provides possibilities for development dual-sensitive or polymers efficient anticancer delivery.

Language: Английский

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Multicomponent Plasmonic Nanoparticles: From Heterostructured Nanoparticles to Colloidal Composite Nanostructures

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(24), P. 12208 - 12278

Published: Dec. 3, 2019

Plasmonic nanostructures possessing unique and versatile optoelectronic properties have been vastly investigated over the past decade. However, full potential of plasmonic nanostructure has not yet fully exploited, particularly with single-component homogeneous structures monotonic properties, addition new components for making multicomponent nanoparticles may lead to new-yet-unexpected or improved properties. Here we define term "multi-component nanoparticles" as hybrid composed two more condensed nanoscale domains distinctive material compositions, shapes, sizes. We reviewed discussed designing principles synthetic strategies efficiently combine multiple form a functionality. In particular, it quite challenging precisely synthesize widely diverse structures, limiting realization heterostructures. To address this challenge, several approaches reported variety different nanoparticles, mainly based on heterogeneous nucleation, atomic replacements, adsorption supports, biomolecule-mediated assemblies. addition, synergistic features such combination pristine finely tuned plasmon resonance coupling, enhanced light-matter interactions, geometry-induced polarization, plasmon-induced energy charge transfer across heterointerface, were reported. review, comprehensively summarize latest advances state-of-art strategies, promising applications nanoparticles. These including heterostructured composite are prepared by direct synthesis physical force- assembly, which hold tremendous plasmon-mediated transfer, magnetic plasmonics, metamolecules, nanobiotechnology.

Language: Английский

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pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery

Journal of Colloid and Interface Science, Journal Year: 2018, Volume and Issue: 536, P. 224 - 234

Published: Oct. 20, 2018

Language: Английский

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PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

Applied Materials Today, Journal Year: 2018, Volume and Issue: 12, P. 177 - 190

Published: May 29, 2018

Language: Английский

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Basic concepts and recent advances in nanogels as carriers for medical applications

Drug Delivery, Journal Year: 2017, Volume and Issue: 24(1), P. 539 - 557

Published: Jan. 1, 2017

Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called next generation drug delivery systems due to their relatively high encapsulation capacity, uniformity, tunable size, ease preparation, minimal toxicity, stability the presence serum, stimuli responsiveness. show a great potential chemotherapy, diagnosis, organ targeting bioactive substances. The main subjects reviewed this article concentrates on: (i) Nanogel assimilation nanomedicine domain; (ii) Features advantages nanogels, characteristics, such as: swelling sensitivity, surface area, functionalization, bioconjugation substances, which taken into account designing structures according application; some data limitations preparation techniques; (iii) Recent progress nanogels carrier genetic material, protein vaccine. majority scientific literature presents multivalency bioconjugated various conditions. Today's research focuses over overcoming restrictions imposed by cost, medical requirements technological issues, for nanogels' commercial scale production integration new platform biomedicine.

Language: Английский

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Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 327, P. 316 - 349

Published: Aug. 12, 2020

Language: Английский

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Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Journal of the American Chemical Society, Journal Year: 2017, Volume and Issue: 139(13), P. 4584 - 4610

Published: Feb. 13, 2017

Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery therapeutics, so forth. Among drug systems (DDSs), smart nanocarriers that respond specific stimuli their environment represent growing field. Nanoplatforms can be activated by an external application light used wide variety photoactivated therapies, light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, addition, activation potential photodynamic therapy, photothermal radiotherapy, protected bioactive moieties, anticancer systems, theranostics (i.e., real-time monitoring tracking combined with therapeutic action different diseases sites organs). Combinations these approaches lead enhanced synergistic employing as trigger or activation. Nonlinear absorption mechanisms such two-photon photon upconversion been employed the design light-responsive DDSs. The integration stimulus into dual/multiresponsive provide spatiotemporal controlled release agents, nanosystems, two more on-demand under conditions, Overall, light-activated nanomedicines DDSs are expected effective therapies against serious cancers, inflammation, infections, cardiovascular disease reduced side effects will open doors toward treatment patients worldwide.

Language: Английский

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Nanoparticle-Mediated Delivery towards Advancing Plant Genetic Engineering

Trends in biotechnology, Journal Year: 2018, Volume and Issue: 36(9), P. 882 - 897

Published: April 24, 2018

Language: Английский

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