Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(29), P. 4078 - 4081
Published: Jan. 1, 2020
A
novel
method
for
the
synthesis
of
3-(2-quinolyl)
chromones
through
a
tandem
[3+2]
cycloaddition/ring-opening/O-arylation
from
ynones
and
quinoline
N-oxides
has
been
developed.
This
protocol
proceeds
under
transition
metal-
additive-free
conditions
can
be
amplified
to
gram
level
in
91%
yield.
3-(1-Isoquinolyl)
3-(2-pyridyl)
are
also
successfully
synthesized
using
isoquinoline
pyridine
basic
conditions.
Various
heteroarene-contaning
were
afforded
30-98%
yields,
which
difficult
obtained
compounds
interest
pharmaceutical
chemistry
chemical
biology.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(9), P. 5586 - 5596
Published: April 6, 2023
Herein,
we
present
a
practical
strategy
for
the
direct
construction
of
structurally
diverse
trifluoromethyl
carbinol-containing
compounds,
especially
CF3-substituted
tertiary
alcohol
with
chromone
derivatives
from
easily
available
o-hydroxyaryl
enaminones
and
trifluoroacetaldehyde/ketone
under
metal-free
conditions.
This
reaction
features
broad
substrate
scope
good
yields
is
scaled
up.
Notably,
one-pot
in
two-steps
obtained
products
amidines
also
developed
to
provide
series
multi-substituted
pyrimidine
bearing
two
unique
hydroxyls
one
containing
functional
units.
Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
362(1), P. 65 - 86
Published: Sept. 20, 2019
Abstract
Dimethyl
sulfoxide
(DMSO)
has
had
a
long
history
of
use
as
polar
solvent
and
active
pharmaceutical
ingredient
in
the
past
decades.
However,
this
decade
DMSO
attracted
attention
scientists
source
oxygen,
carbon
or
sulfur
wide
range
organic
reactions.
In
review,
we
have
summarized
classified
latest
findings
area
based
on
applications
single
dual
synthon.
magnified
image
Asian Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
8(6), P. 767 - 776
Published: April 23, 2019
Abstract
Chromone
is
a
heterocyclic
entity
presents
in
number
of
natural
products,
clinical
pharmaceuticals,
as
well
molecules
with
enriched
biological
functions.
As
cutting‐edge
area,
the
synthesis
chromones
has
seen
spectacular
progress
over
past
decade.
Among
available
synthetic
modes
toward
chromone
scaffolds,
annulation
ortho
‐hydroxyphenyl
functionalized
N,N
‐disubstituted
enaminones
turned
out
to
be
one
most
reliable
and
practical
ones.
By
combining
this
featured
transformation
vinyl
α‐C−H
bond
enaminone
structure,
large
tandem
reactions
providing
structurally
diverse
C3‐functionalization
have
been
recently
realized.
strategy
valuable
an
important
branch
enaminone‐based
organic
synthesis,
such
are
highly
instructive
for
chemistry
many
other
disciplines
related
moiety.
Herein,
we
present
first
time
research
advances
on
C3‐functionalized
via
C−H
elaboration
tertiary
enaminones.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(18), P. 2770 - 2775
Published: Jan. 1, 2020
The
synthesis
of
3-trifluoromethyl
chromones
has
been
realized
via
transition
metal-free
reactions
o-hydroxyphenyl
enaminones
and
the
Langlois
reagent
cascade
C–H
trifluoromethylation
chromone
annulation.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 7188 - 7198
Published: May 12, 2023
Rongalite
has
been
used
as
a
cheap
and
efficient
carbon
synthon
for
the
synthesis
of
divergent
N-heteroaromatics,
including
different
pyridines
quinolines.
The
selective
products
can
be
achieved
by
employing
enaminones
or
enaminones/anilines
reaction
partners.
In
addition,
compared
with
using
conventional
aldehyde
synthons,
rongalite
displays
an
evident
advantage
in
providing
considerably
higher
product
yields
under
milder
conditions.
GC-MS
analysis
process
performed
to
probe
possible
mechanism.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(9), P. 1107 - 1112
Published: Jan. 1, 2020
The
synthesis
of
C2-nitrogenated
chromones
has
been
performed
via
reactions
enaminones
and
nitrogen
nucleophiles
based
on
an
unconventional
β-C–H
bond
functionalization
a
featured
chromone
annulation
enaminones.
Chemistry - A European Journal,
Journal Year:
2020,
Volume and Issue:
26(72), P. 17289 - 17317
Published: May 29, 2020
Abstract
Sulfur‐containing
scaffold,
as
a
ubiquitous
structural
motif,
has
been
frequently
used
in
natural
products,
bioactive
chemicals
and
pharmaceuticals,
particularly
C−S/N−S
bonds
are
indispensable
many
biological
important
compounds
pharmaceuticals.
Development
of
mild
general
methods
for
formation
great
significance
modern
research.
Iodine
its
derivatives
have
recognized
inexpensive,
environmentally
benign
easy‐handled
catalysts
or
reagents
to
promote
the
construction
under
reaction
conditions,
with
good
regioselectivities
broad
substrate
scope.
Especially
based
on
this,
several
new
strategies,
such
oxidation
relay
strategy,
greatly
developed
accelerated
advancement
this
field.
This
review
focuses
recent
advances
iodine
promoted
hybridized
formation.
The
features
mechanisms
corresponding
reactions
summarized
results
some
cases
compared
those
previous
reports.
In
addition,
future
domain
is
discussed.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
24(1), P. 223 - 227
Published: Dec. 16, 2021
Rongalite
has
been
used
in
several
challenging
synthetic
transformations
with
operationally
simple
and
effective
protocols.
However,
the
employment
of
multiple
characteristics
rongalite
chemistry
is
comparatively
little
known.
Herein
we
report
a
separate-embedding
type
sulfonylmethylation
sulfoxonium
ylides
which
concurrently
acted
as
sulfone
source,
C1
synthon,
radical
initiator,
potential
reducing
reagent
for
first
time.
Notably,
this
facile
easy-handling
reaction
does
not
require
catalyst
or
prefunctionalized
reagents.
