One-Pot Synthesis of 2-Sulfonamidobenzo[b]thiophenes Enabled by a Mild Protonative Activation of Ynamides DOI
Hee Nam Lim, Hyun‐Suk Yeom,

Solbin Kim

et al.

Synthesis, Journal Year: 2022, Volume and Issue: 54(24), P. 5451 - 5460

Published: Aug. 23, 2022

Abstract The silica gel promoted or solvent-promoted protonative intramolecular cyclization of ynamides containing an o-(methylthio)aryl group resulted in the one-pot formation biologically important ­benzo[b]thiophenes. Compared with ynamide activation methods that use strong Brønsted acids expensive transition metals, this protocol is mild and economical. Due to these merits, various functionalized 2-amidobenzo[b]thiophenes were furnished a convenient way.

Language: Английский

One-Pot Synthesis of 2-Sulfonamidobenzo[b]thiophenes Enabled by a Mild Protonative Activation of Ynamides DOI
Hee Nam Lim, Hyun‐Suk Yeom,

Solbin Kim

et al.

Synthesis, Journal Year: 2022, Volume and Issue: 54(24), P. 5451 - 5460

Published: Aug. 23, 2022

Abstract The silica gel promoted or solvent-promoted protonative intramolecular cyclization of ynamides containing an o-(methylthio)aryl group resulted in the one-pot formation biologically important ­benzo[b]thiophenes. Compared with ynamide activation methods that use strong Brønsted acids expensive transition metals, this protocol is mild and economical. Due to these merits, various functionalized 2-amidobenzo[b]thiophenes were furnished a convenient way.

Language: Английский

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