Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 7, 2025
Metals
have
long
held
a
significant
role
in
the
human
body
and
been
utilized
as
mineral
medicines
for
thousands
of
years.
The
modern
advancement
metals
pharmacology,
particularly
metallodrugs,
has
become
crucial
disease
treatment.
As
machanism
metallodurgsare
increasingly
uncovered,
some
metallodrugs
are
already
approved
by
FDA
widely
used
treating
antitumor,
antidiabetes,
antibacterial.
Therefore,
thorough
understanding
metallodrug
development
is
essential
advancing
future
study.
This
review
offers
an
in-depth
examination
evolution
applications
within
contemporary
medicine.
We
specifically
aim
to
summarize
historical
trajectory
Traditional
Chinese
Mineral
Medicine
analyzing
key
texts
representative
medicines.
Additionally,
we
discuss
recent
advancements
metallodrugs'
mechanisms,
such
protein
interactions,
enzyme
inhibition,
DNA
reactive
oxygen
species
(ROS)
generation,
cellular
structure
targeting.
Furthermore,
address
challenges
propose
potential
solutions.
Lastly,
outline
directions
enhance
their
efficacy
effectiveness.
progression
broadened
contributed
significantly
patient
health,
creating
good
healthcare
solutions
global
population.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(10)
Published: Feb. 5, 2023
Due
to
radiation
resistance
and
the
immunosuppressive
microenvironment
of
metastatic
osteosarcoma,
novel
radiosensitizers
that
can
sensitize
radiotherapy
(RT)
antitumor
immunity
synchronously
urgently
needed.
Here,
authors
developed
a
nanoscale
metal-organic
framework
(MOF,
named
TZM)
by
co-doping
high-atomic
elements
Ta
Zr
as
metal
nodes
porphyrinic
molecules
(tetrakis(4-carboxyphenyl)porphyrin
(TCPP))
photosensitizing
ligand.
Given
3D
arrays
ultra-small
heavy
metals,
porous
TZM
serves
an
efficient
attenuator
absorbing
X-ray
energy
sensitizing
hydroxyl
radical
generation
for
RT.
Ta-Zr
narrowed
highest
occupied
molecular
orbital-lowest
unoccupied
orbital
(HOMO-LUMO)
gap
exhibited
close
levels
between
singlet
triplet
photoexcited
states,
facilitating
transfer
photosensitizer
TCPP
oxygen
(
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(23), P. 6457 - 6466
Published: Jan. 1, 2023
A
photo-responsive
full-color
lanthanide
supramolecular
switch
was
constructed
from
a
synthetic
2,6-pyridine
dicarboxylic
acid
(DPA)-modified
pillar[5]arene
(H)
complexing
with
ion
(Ln3+
=
Tb3+
and
Eu3+)
dicationic
diarylethene
derivative
(G1)
through
noncovalent
assembly.
Benefiting
the
strong
complexation
between
DPA
Ln3+
3
:
1
stoichiometric
ratio,
complex
H/Ln3+
presented
an
emerging
emission
in
aqueous
organic
phase.
Subsequently,
network
polymer
formed
by
further
encapsulating
G1via
hydrophobic
cavity
of
pillar[5]arene,
which
greatly
contributed
to
increased
intensity
lifetime,
also
resulted
formation
light
switch.
Moreover,
luminescence,
especially
white
emission,
achieved
(CIE:
0.31,
0.32)
dichloromethane
0.33)
solutions
adjustment
different
ratios
Eu3+.
Notably,
photo-reversible
luminescence
properties
assembly
were
tuned
via
alternant
UV/vis
irradiation
due
conformation-dependent
photochromic
energy
transfer
open/closed-ring
diarylethene.
Ultimately,
prepared
successfully
applied
anti-counterfeiting
use
intelligent
multicolored
writing
inks,
presents
new
opportunities
for
design
advanced
stimuli-responsive
on-demand
color
tuning
luminescent
materials.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(27)
Published: Feb. 25, 2024
Abstract
Despite
multifunctional
theranostics
hold
vast
potential
in
deep
tissue
bioimaging
and
tumor
therapy,
activatable
nanomedicine
with
integration
of
precise
diagnosis
effective
treatment
is
usually
achieved
at
the
cost
complicated
synthesis
chemistries.
Here,
a
facile
way
to
design
bioresponsive
Ag
2
S‐Ag
Janus
probes
coated
by
polyethylene
glycol
(PEG)
(denoted
as
AAP)
showed,
active
second
near‐infrared
window
(NIR‐II,
1000–1700
nm).
In
microenvironment,
part
can
yield
hydroxyl
radicals
(·OH)
consuming
H
O
for
high‐efficiency
chemodynamic
therapy
(CDT),
while
S
has
impressive
photothermal
(PTT).
The
synergistic
benefits
from
parts
further
boosted
CDT
effect
AAP
high
conversion
efficiency
up
56.8%.
Moreover,
multiple
lines
evidence
supported
that
extremely
faint
fluorescence
be
significantly
activated
overexpressed
levels
,
showing
bright
NIR‐II
emission
≈1270
nm
over
5.6
×
10
3
‐fold
increase
signal
intensity.
are
easily
imaging
tumor‐specific
identification,
effectively
ablate
tissues
inhibition
rate
96.2%.
This
study
expects
probe
will
open
new
route
achieve
window.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(7), P. 4620 - 4631
Published: Feb. 8, 2024
Pancreatic
cancer
is
highly
lethal.
New
diagnostic
and
treatment
modalities
are
desperately
needed.
We
report
here
that
an
expanded
porphyrin,
cyclo[8]pyrrole
(CP),
with
a
high
extinction
coefficient
(89.16
L/g·cm)
within
the
second
near-infrared
window
(NIR-II),
may
be
formulated
αvβ3-specific
targeting
peptide,
cyclic-Arg-Gly-Asp
(cRGD),
to
form
cRGD-CP
nanoparticles
(cRGD-CPNPs)
promising
NIR-II
photothermal
(PT)
therapeutic
photoacoustic
(PA)
imaging
properties.
Studies
ring-array
PA
tomography
system,
coupled
analysis
of
control
lacking
element
(CPNPs),
revealed
cRGD
conjugation
promoted
delivery
NPs
through
abnormal
vessels
around
tumor
solid
core.
This
proved
true
in
both
subcutaneous
orthotopic
pancreatic
mice
models,
as
confirmed
by
immunofluorescent
studies.
In
combination
laser
photoirradiation,
cRGD-CPNPs
provided
near-baseline
growth
inhibition
PTT
vitro
vivo.
Notably,
present
photoirradiation
was
found
inhibit
intra-abdominal
metastases
mouse
model.
The
also
displayed
good
biosafety
profiles,
inferred
from
tomography,
blood
analyses,
H&E
staining.
They
thus
appear
for
use
combined
PT
cancer.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(3), P. 688 - 688
Published: Feb. 1, 2024
Rare
earths,
scandium,
yttrium,
and
the
fifteen
lanthanoids
from
lanthanum
to
lutetium,
are
classified
as
critical
metals
because
of
their
ubiquity
in
daily
life.
They
present
magnets
cars,
especially
electric
cars;
green
electricity
generating
systems
computers;
steel
manufacturing;
glass
light
emission
materials
for
safety
lighting
lasers;
exhaust
catalysts
supports;
artificial
rubber
production;
agriculture
animal
husbandry;
health
cancer
diagnosis
treatment;
a
variety
electronic
products
essential
modern
living.
have
potential
replace
toxic
chromates
corrosion
inhibition,
magnetic
refrigeration,
new
materials,
role
may
expand.
This
review
examines
sustainability,
environment,
recycling,
crop
production,
feedstocks,
catalysis,
health,
well
considering
future
uses.
iRadiology,
Journal Year:
2023,
Volume and Issue:
1(1), P. 36 - 60
Published: March 1, 2023
Abstract
Emerging
stimuli‐responsive
composite
probes
active
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
hold
vast
potential
for
improving
vivo
imaging
performance
with
minimized
noise
interference.
The
interactions
among
external
irradiation,
shell
species,
and
emissive
core
are
key
factors
design
of
smart
structures.
irradiation
provides
energy
species
to
generate
intense
NIR‐II
fluorescence
signals,
while
transfer
process
hinders
emission
inner
structure
probes.
However,
if
pathophysiological
stimuli
interrupt
above
processes,
then
signals
recovered.
This
review
covers
based
on
diverse
fluorescent
responding
various
biological
stimuli,
including
ONOO
−
,
overexpressed
reactive
sulfur
abnormally
expressed
enzymes,
abnormal
levels
physiological
metabolites.
Finally,
appreciate
these
advances,
challenges
perspectives
highlighted.
Small,
Journal Year:
2023,
Volume and Issue:
19(46)
Published: July 13, 2023
Macrocyclic
confinement-induced
supramolecular
luminescence
materials
have
important
application
value
in
the
fields
of
bio-sensing,
cell
imaging,
and
information
anti-counterfeiting.
Herein,
a
tunable
multicolor
lanthanide
assembly
with
white
light
emission
is
reported,
which
constructed
by
co-assembly
cucurbit[7]uril
(CB[7])
encapsulating
naphthylimidazolium
dicarboxylic
acid
(G1
)/Ln
(Eu3+
/Tb3+
)
complex
carbon
quantum
dots
(CD).
Benefiting
from
macrocyclic
confinement
effect
CB[7],
not
only
extends
fluorescence
intensity
G1
36
times,
but
also
increases
yield
28
times
lifetime
12
times.
Furthermore,
CB[7]/G1
/Ln
can
further
co-assemble
CD
diarylethene
derivatives
(DAE)
to
realize
intelligently-regulated
full-color
spectrum
including
light,
results
competitive
encapsulation
adamantylamine
change
pH,
photochromic
DAE.
The
multi-level
logic
gate
based
on
successfully
applied
anti-counterfeiting
system
storage,
providing
an
effective
method
for
research
new
luminescent
intelligent
materials.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(16), P. 6356 - 6365
Published: April 8, 2024
Renal
fibrosis
poses
a
significant
threat
to
individuals
suffering
from
chronic
progressive
kidney
disease.
Given
the
absence
of
effective
medications
for
treating
renal
fibrosis,
it
becomes
crucial
assess
extent
in
real
time
and
explore
development
novel
drugs
with
substantial
therapeutic
benefits.
Due
accumulation
tissue
damage
uncontrolled
deposition
fibrotic
matrix
during
course
disease,
there
is
an
increase
viscosity
both
intracellularly
extracellularly.
Therefore,
viscosity-sensitive
near-infrared
fluorescence
(NIRF)
photoacoustic
(PA)
imaging
probe,
