Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(8), P. 236 - 236
Published: Aug. 22, 2024
Low
molecular
weight
chitosan
selenium
nanoparticles
(LCS-SeNPs),
a
biologically
active
compound
derived
from
polysaccharides,
have
demonstrated
potential
in
addressing
obesity.
However,
the
mechanism
through
which
LCS-SeNPs
alleviate
high-fat
diet
(HFD)-induced
non-alcoholic
fatty
liver
disease
(NAFLD)
remains
unclear.
Our
results
elucidated
that
significantly
inhibited
fat
accumulation
and
markedly
improved
intestinal
barrier
by
increasing
mucus
secretion
goblet
cells.
Moreover,
reshaped
flora
composition
abundance
of
mucus-associated
microbiota
(Bifidobacterium,
Akkermansia,
Muribaculaceae_unclassified)
decreasing
obesity-contributed
bacterium
(Anaerotruncus,
Lachnoclostridium,
Proteus).
The
modulation
influenced
several
metabolic
pathways,
including
bile
acid
secretion,
purine
metabolites,
tryptophan
derivation.
Meanwhile,
glycocholic
tauro-beta-muricholic
were
reduced
LCS-SeNP
group.
study
suggests
crucial
role
metabolism,
providing
new
theoretical
foundation
for
utilizing
polysaccharides
intervention
HFD-induced
NAFLD.
Journal of Advanced Research,
Journal Year:
2023,
Volume and Issue:
52, P. 151 - 170
Published: June 2, 2023
The
relationship
between
gut
microbiota
and
human
health
has
gradually
been
recognized.
Increasing
studies
show
that
the
disorder
of
is
related
to
occurrence
development
many
diseases.
Metabolites
produced
by
are
responsible
for
their
extensive
regulatory
roles.
In
addition,
naturally
derived
medicine
food
homology
species
with
low
toxicity
high
efficiency
have
clearly
defined
owing
outstanding
physiological
pharmacological
properties
in
disease
prevention
treatment.Based
on
supporting
evidence,
current
review
summarizes
representative
work
targeting
regulate
host
pathophysiology
discusses
challenges
prospects
this
field.
It
aims
facilitate
understanding
among
species,
microbiota,
further
stimulate
advancement
more
relevant
research.As
reveals,
from
initial
practical
application
mechanism
studies,
evolved
into
an
irrefutable
interaction.
On
one
hand,
through
affecting
population
structure,
metabolism,
function
maintain
homeostasis
intestinal
microenvironment
microbiota.
other
also
involved
bioconversion
active
ingredients
thus
influences
properties.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2838 - 2838
Published: Aug. 24, 2024
The
gut
microbiota
constitutes
a
complex
ecosystem,
comprising
trillions
of
microbes
that
have
co-evolved
with
their
host
over
hundreds
millions
years.
Over
the
past
decade,
growing
body
knowledge
has
underscored
intricate
connections
among
diet,
microbiota,
and
human
health.
Bioactive
polysaccharides
(BPs)
from
natural
sources
like
medicinal
plants,
seaweeds,
fungi
diverse
biological
functions
including
antioxidant,
immunoregulatory,
metabolic
activities.
Their
effects
are
closely
tied
to
which
metabolizes
BPs
into
health-influencing
compounds.
Understanding
how
interact
is
critical
for
harnessing
potential
health
benefits.
This
review
provides
an
overview
focusing
on
its
role
in
diseases
obesity,
type
II
diabetes
mellitus,
non-alcoholic
fatty
liver
disease,
cardiovascular
diseases.
It
explores
basic
characteristics
several
impact
microbiota.
Given
significance
health,
we
summarize
these
BPs,
particularly
terms
immunoregulatory
activities,
blood
sugar,
hypolipidemic
effect,
thus
providing
valuable
reference
understanding
benefits
treating
These
properties
make
promising
agents
preventing
comprehensive
mechanisms
by
exert
through
opens
new
avenues
developing
targeted
therapies
improve
Food & Function,
Journal Year:
2022,
Volume and Issue:
13(24), P. 12883 - 12895
Published: Jan. 1, 2022
The
chemical
structure
and
pharmacological
activity
of
Polygonatum
cyrtonema
Hua
polysaccharides
have
garnered
significant
attention
in
recent
years.
In
this
study,
a
homogeneous
polysaccharide,
PCP1,
was
extracted
from
P.
rhizomes
purified.
Monosaccharide
composition
analysis
showed
that
PCP1
is
primarily
composed
fructose,
glucose,
mannose.
Chemical
the
main
chain
mainly
→1)-β-D-Fruf-(2→
→1,6)-β-D-Fruf-(2→,
with
small
amounts
→6)-α-D-Glcp-(1→,
→4)-β-D-Manp-(1→,
β-D-Glcp-(1→.
side
β-D-Fruf-(2→
linked
at
C-6
→1,6)-β-D-Fruf-(2→.
vivo
experiments
mitigates
liver
pathological
damage,
improves
abnormal
lipid
metabolism
oxidative
stress,
promotes
production
short-chain
fatty
acids,
balances
intestinal
microbiota
non-alcoholic
disease
(NAFLD)
mice.
Thus,
can
be
used
as
natural
ingredient
functional
foods
for
treatment
NAFLD.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(17), P. 3722 - 3722
Published: Aug. 25, 2023
Metabolic
(dysfunction)
associated
fatty
liver
disease
(MAFLD)
is
recognized
as
the
most
prevalent
chronic
globally.
However,
its
pathogenesis
remains
incompletely
understood.
Recent
advancements
in
gut-liver
axis
offer
novel
insights
into
development
of
MAFLD.
Polysaccharides,
primarily
derived
from
fungal
and
algal
sources,
abundantly
exist
human
diet
exert
beneficial
effects
on
glycometabolism,
lipid
metabolism,
inflammation,
immune
modulation,
oxidative
stress,
release
Numerous
studies
have
demonstrated
that
these
bioactivities
polysaccharides
are
with
their
prebiotic
properties,
including
ability
to
modulate
gut
microbiome
profile,
maintain
barrier
integrity,
regulate
metabolites
produced
by
microbiota
such
lipopolysaccharide
(LPS),
short-chain
acids
(SCFAs),
bile
(BAs),
contribute
intestinal
homeostasis.
This
narrative
review
aims
present
a
comprehensive
summary
current
understanding
protective
MAFLD
through
interactions
metabolites.
Specifically,
we
highlight
potential
molecular
mechanisms
underlying
polysaccharides,
which
may
give
new
avenues
for
prevention
treatment
