Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study

Mini-Reviews in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(2), P. 246 - 270

Published: May 1, 2023

Abstract: Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold position of interest in the fields synthetic medicinal chemistry, pharmacology, material sciences physics. Spirobarbiturate which incorporate barbituric ring derivatives into spirocyclic structures emerged as attractive targets for drug discovery they are known to exhibit far-ranging pharmacological applications. In this review, we aim bring light extensive, contemporary research applied synthesis different spirobarbiturates having varied sizes (3, 5, 6 7 membered) classified manner. It presents reported methods along with their mechanistic pathways well activities some these synthesized biologically significant motifs.

Language: Английский

---

Synthesis of Benzofuran Derivatives via a DMAP-Mediated Tandem Cyclization Reaction Involving ortho-Hydroxy α-Aminosulfones

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3725 - 3725

Published: Aug. 6, 2024

An efficient cascade cyclization strategy was developed to synthesize aminobenzofuran spiroindanone and spirobarbituric acid derivatives utilizing 2-bromo-1,3-indandione, 5-bromo-1,3-dimethylbarbituric acid,

Language: Английский

---

Pd/Mengphos-Catalyzed High-order [4+4] Cycloaddition for Efficient Synthesis of Oxazocines

Synthesis, Journal Year: 2024, Volume and Issue: 56(24), P. 3870 - 3878

Published: Oct. 7, 2024

Abstract The development of new catalytic systems that enable regio- and chemoselective construction diversely functionalized oxazocines is an important topic in organic synthesis pharmacochemistry. Herein, a novel Pd/Mengphos complex was designed applied palladium-catalyzed high-order [4+4] cycloaddition 2-substituted allylic carbonates to α,β-unsaturated imines, allowing facile access versatile good yields with excellent b/l Z/E selectivities (up 92% yield complete selectivities). reaction exhibited broad substrate scope, mild conditions, functional group compatibility. In addition, asymmetric version has also been tested, affording the desired moderate enantioselectivity.

Language: Английский

---

Recent Advances in Palladium-Catalyzed Annulations for the Synthesis of Pyrrolidines

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141010 - 141010

Published: Dec. 1, 2024

Language: Английский

---