Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(37)
Published: May 22, 2024
Abstract
Though
platinum
(Pt)‐based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep‐seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near‐infrared
(NIR)
light‐activated
and
lysosomal
targeted
Pt(II)
metallacycle
(
1
)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
response
via
multiple‐regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth‐activated
ROS
production
(~7
mm),
accompanied
by
strong
anti‐diffusion
anti‐ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer‐oxaliplatin
(300
μM).
vivo
,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
+
/CD4
T
Foxp3
depletion
negligible
adverse
effects.
This
study
pioneers
promising
avenue
safe
metal‐based
agents
immunotherapy.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(14), P. 5360 - 5360
Published: July 12, 2023
Near-infrared
(NIR)
fluorescence
is
a
noninvasive,
highly
sensitive,
and
high-resolution
modality
with
great
potential
for
in
vivo
imaging.
Compared
“Always-On”
probes,
activatable
NIR
fluorescent
probes
“Turn-Off/On”
or
“Ratiometric”
signals
at
target
sites
exhibit
better
signal-to-noise
ratio
(SNR),
wherein
enzymes
are
one
of
the
ideal
triggers
probe
activation,
which
play
vital
roles
variety
biological
processes.
In
this
review,
we
provide
an
overview
enzyme-activatable
concentrate
on
design
strategies
sensing
mechanisms.
We
focus
aggregation/dispersion
state
fluorophores
after
interaction
finally
discuss
current
challenges
some
perspective
ideas
construction
probes.
Small,
Journal Year:
2023,
Volume and Issue:
20(2)
Published: Sept. 1, 2023
Abstract
Discrete
organometallic
complexes
with
defined
structures
are
proceeding
rapidly
in
combating
malignant
tumors
due
to
their
multipronged
treatment
modalities.
Many
innovative
superiorities,
such
as
high
antitumor
activity,
extremely
low
systemic
toxicity,
active
targeting
ability,
and
enhanced
cellular
uptake,
make
them
more
competent
for
clinical
applications
than
individual
precursors.
In
particular,
coordination‐induced
regulation
of
luminescence
photophysical
properties
organic
light‐emitting
ligands
has
demonstrated
significant
potential
the
timely
evaluation
therapeutic
efficacy
by
bioimaging
enabled
synergistic
photodynamic
therapy
(PDT)
or
photothermal
(PTT).
This
review
highlights
instructive
examples
multimodal
radiochemotherapy
platforms
cancer
ablation
based
on
self‐assembled
metallacycles/metallacages,
which
would
be
classified
functions
a
progressive
manner.
Finally,
essential
demands
some
plausible
prospects
this
field
also
presented.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(37)
Published: May 22, 2024
Abstract
Though
platinum
(Pt)‐based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep‐seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near‐infrared
(NIR)
light‐activated
and
lysosomal
targeted
Pt(II)
metallacycle
(
1
)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
response
via
multiple‐regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth‐activated
ROS
production
(~7
mm),
accompanied
by
strong
anti‐diffusion
anti‐ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer‐oxaliplatin
(300
μM).
vivo
,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
+
/CD4
T
Foxp3
depletion
negligible
adverse
effects.
This
study
pioneers
promising
avenue
safe
metal‐based
agents
immunotherapy.
