A Review on Functionalization of Benzo‐5,6‐Fused Bicyclic Heteroaromatic Compounds

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(22)

Published: July 16, 2024

Abstract Over the decades, functionalized heteroaromatic compounds and their scaffolds have drawn significant attention in synthetic organic chemistry as well interdisciplinary sciences due to prevalence natural products, hormones, vitamins, applications pharmaceuticals, agrochemicals, veterinary dyes pigments, bio‐imaging, semiconductors, optoelectronics, etc. This review explores various strategies for functionalization of numerous 5,6 benzo‐fused derivatives such indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, benzothiazole benzotriazole through methods including C−H activation, cross‐coupling, metal catalysis, photo‐catalysis, electrocatalysis organocatalysis recent years (2019–2023). Highly heterocyclic are important precursors synthesizing many bioactive drugs like fenbendazole, viozan, griseofulvin, zileuton, flunoxaprofen, optoelectronic materials,

Language: Английский

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Photocatalytic synthesis of unsymmetrical Bis-N-heterocycles

Journal of Catalysis, Journal Year: 2024, Volume and Issue: 438, P. 115673 - 115673

Published: July 27, 2024

Language: Английский

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Co(III) ‐Catalyzed Regioselective [4+2]‐Annulation of N‐Chlorobenzamide with Allenes and Vinyl Acetate

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 28, 2023

Abstract A regioselective annulation protocol of N ‐chlorobenzamide with allenes and vinyl acetate is reported using a less expensive catalytic system, i. e . Co(III) catalysis Na 2 CO 3 as base. (CO) NH−Cl acts both, an internal oxidant directing group. Allenes are successfully annulated ‐chlorobenzamide, providing different exocyclic isoquinolone derivatives in good to moderate yield. Notably, acetylene surrogate undergoes the developed provide excellent Interestingly, situ deprotection acetyl group allowed quantitative synthesis hydroxyisoquinolone.

Language: Английский

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Cobalt Catalysis: C7 Alkynylation of Indolines with a Bromoalkyne

Synthesis, Journal Year: 2023, Volume and Issue: 56(05), P. 751 - 757

Published: Nov. 28, 2023

Abstract A method for the cobalt-catalyzed C-7 alkynylation of indolines with (bromoethynyl)triisopropylsilane under mild conditions is described, leading to a diverse range alkynylated in good excellent yields. Kinetic isotope studies indicate that formation cobaltacycle might be turnover-limiting step. Additionally, gram-scale synthesis and oxidation an indoline indole have been carried out successfully

Language: Английский

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Rh-Catalyzed Functionalization of N-Heterocycles Through C–H Activation

Topics in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 89 - 157

Published: Jan. 1, 2024

Language: Английский

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Thiophene and benzo[b]thiophene

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 89 - 122

Published: Jan. 1, 2024

Language: Английский

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Six-membered ring systems: Pyridines and benzo analogs

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 309 - 354

Published: Jan. 1, 2024

Language: Английский

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Rh-Catalyzed Unsymmetrical Heterobiaryl Synthesis via a Dual C–H Activation Cross-Coupling Process

Synfacts, Journal Year: 2023, Volume and Issue: 19(10), P. 0996 - 0996

Published: Sept. 14, 2023

Key words rhodium catalysis - C–H activation directing groups heterobiaryl synthesis silver

Language: Английский

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