Supramolecular J‐ and H‐aggregation of Napthalimide‐conjugated Dipeptide in Mixed‐solvent Systems and Its Application in Cell Imaging

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(22)

Published: Aug. 6, 2024

Abstract In this work, a core‐substituted NMI‐conjugated dipeptide (4MNLV) was extensively studied in mixed solvent systems to explore the polarity effect on self‐assembly pattern and their photophysical property. 4MNLV adopted J‐ or H ‐ type aggregation depending upon index of system chosen. The process achieved through anti‐solvent effect. UV‐vis study suggested that if stock solution diluted with relatively more polar (compared solvent), then acquired by showing red‐shift absorption maxima (λ max ). Conversely, when less solvent, H‐ observed, where blue shift λ noticed. emission spectra lifetime self‐assembled materials were also influenced chosen system. chirotopic behaviour these CD spectroscopy. Morphological indicated formation helical nanofibrillar structures. bright green fluorescence highly biocompatible naphthalimide‐peptide conjugate used for cell imaging application, indicating its futuristic scope.

Language: Английский

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Supramolecular Gelation Based on Native Amino Acid Tyrosine and Its Charge-Transfer Complex Formation

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Self-assembly of amino acids and short-peptide derivatives attracted significant curiosity worldwide due to their unique self-assembly process wide variety applications. Amino acid is considered one the important synthons in supramolecular chemistry. processes applications unfunctionalized native have been less reported literature. In this article, we are first-time reporting tyrosine (Tyr), an aromatic acid, dimethyl sulfoxide (DMSO) solvent. Most studies related Tyr were different aqueous solutions. our work, studied several common organic solvents found that could self-assemble into a gel The was investigated by techniques, such as UV-vis, fluorescence, FTIR, NMR spectroscopy. Morphological features on nanoscale through scanning electron microscopy (SEM). SEM images indicated formation nanofibrils with high aspect ratios. property rheological experiments. Computational study DMSO medium suggested noncovalent interactions like hydrogen bonding π-π stacking among molecules played prominent role. Finally, charge-transfer complex ability electron-rich electron-deficient 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) studied. presence DDQ formation, converted reddish color solution, fibrillar morphologies collapsed.

Language: Английский

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Exploring the Photophysical Properties of Self-Assembled Phenylalanine: Aggregation-Induced Emission, Fluorescent Hydrogel Formation and Selective Interaction with Hemin

ACS Applied Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Cold Atmospheric Plasma-Driven Structural Transformation of Self-Assembled Fmoc-Trp and Fmoc-Phe into Supramolecular Aggregated Assemblies

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Supramolecular chemistry plays a key role in the design of functional nanomaterials, and self-assembly behavior amino acids modified with Fmoc group has gained significant attention for its potential nanotechnology biomedicine. This study investigates N-9-fluorenylmethoxycarbonyl(Fmoc)-modified impact cold atmospheric plasma (CAP) on their transformation from 2D into 3D supramolecular aggregates. Fmoc-phenylalanine (Fmoc-F), derivative phenylalanine, primarily relies π-π stacking interactions to form structures while Fmoc-tryptophan (Fmoc-W), tryptophan, engages both hydrogen bonding due presence an indole ring nitrogen atom, leading stronger more stable Upon CAP treatment, Fmoc-F forms aggregates containing β-sheet moieties binding thioflavin T (dye) at concentrations as low 10 μM, whereas Fmoc-W 68 μM. These differences aggregation behaviors can be attributed distinct molecular two derivatives. The rapid treatment time nonthermal properties regulate direct process, promoting formation complex structures, fluorescence spectra revealing aggregation-induced quenching (ACQ). Characterization techniques confirm assemblies, offering valuable insights Fmoc-amino acid-based materials applications biomimetic materials, cationic dye binding, drug delivery, tissue engineering.

Language: Английский

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Programmed Self-Assembly of Conjugated Oligomer-Based Helical Nanofibres through Hydrogen Bonding Interactions

Materials Advances, Journal Year: 2024, Volume and Issue: 6(1), P. 241 - 247

Published: Nov. 28, 2024

Self-assembly of m-phenylene vinylene derivatives with amino acid functional groups produces fluorescent nanofibres via hydrogen bonding, chiral centres inducing helicity. These nanostructures exhibit enhanced thermal stability and fluorescence properties, advancing biomimetic material design.

Language: Английский

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