Dehydrogenative α,γ-Diphosphinylation of Allylamines Enabled by Photoinduced Cobaloxime Catalysis DOI
Jun Guo, Yana Zhang, Miaomiao Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

A regioselective radical α,γ-diphosphinylation of allylamines with secondary phosphine oxides by photoinduced cobaloxime catalysis is described. The reaction tolerates a wide range and oxides, affording α-amino diphosphine dioxides in moderate to good yields hydrogen evolution. synthesis new monoxide ligands the promising antitumor activities products demonstrate great potential applications this approach drug discovery. detailed mechanism studies indicate that likely proceeds through dehydrogenative allylic phosphinylation nucleophilic addition process.

Language: Английский

Dehydrogenative α,γ-Diphosphinylation of Allylamines Enabled by Photoinduced Cobaloxime Catalysis DOI
Jun Guo, Yana Zhang, Miaomiao Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

A regioselective radical α,γ-diphosphinylation of allylamines with secondary phosphine oxides by photoinduced cobaloxime catalysis is described. The reaction tolerates a wide range and oxides, affording α-amino diphosphine dioxides in moderate to good yields hydrogen evolution. synthesis new monoxide ligands the promising antitumor activities products demonstrate great potential applications this approach drug discovery. detailed mechanism studies indicate that likely proceeds through dehydrogenative allylic phosphinylation nucleophilic addition process.

Language: Английский

Citations

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