Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 8, 2025

Abstract Gastric cancer (GC) is one of the most common malignant tumors worldwide, and its treatment has been a focus medical research. Herein we systematically review current status advancements in targeted therapy immunotherapy for GC, which have emerged as important strategies recent years with great potential, summarize efficacy safety such treatments. Targeted therapies against key targets including epidermal growth factor receptor (EGFR), human 2 (HER2), vascular endothelial (VEGF)/VEGF (VEGFR), shown remarkable therapeutic efficacies by inhibiting tumor progression and/or blood supply. In particular, markable breakthroughs made HER2-targeting drugs HER2-positive GC patients. To address intrinsic acquired resistances to drugs, novel agents bispecific antibodies antibody–drug conjugates (ADC) targeting HER2 developed. Immunotherapy enhances recognition elimination cells activating body anticancer immune system. Programmed cell death protein 1 (PD-1) programmed death-ligand (PD-L1) are commonly used immunotherapeutic some success treatment. Innovative modalities, adoptive therapy, vaccines, non-specific immunomodulators oncolytic viruses promise early-stage clinical trials GC. Clinical supported that can significantly improve survival quality life However, effects need be further improved more personalized, advancement researches on microenvironment. Further studies remain needed issues drug resistance adverse events pertaining The combined application individualized should explored developed, provide effective treatments

Language: Английский

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Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375

Published: March 15, 2025

Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions

Language: Английский

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Nanoparticles, a promising treatment for gastric cancer

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Global research on nanomaterials for liver cancer from 2004 to 2023: a bibliometric and visual analysis

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 26, 2024

Abstract Background Primary liver cancer, particularly hepatocellular carcinoma, is one of the most common gastrointestinal cancers. An increasing number studies indicate that nanomaterials play a significant role in diagnosis and treatment cancer. However, despite extensive diverse research on bibliometric this field have not yet been reported. This study aims to comprehensively evaluate application prospects development trends primary cancer over past 20 years. By elucidating current state we intend provide valuable reference information for researchers field. Methods We conducted comprehensive search Web Science Core Collection publications related from January 1, 2004, December 31, 2023. Relevant literature was selected based specific inclusion exclusion criteria. These were subsequently analyzed using CiteSpace, VOSviewer, R package "bibliometrix" identify trends, influential countries, institutions, authors, journals, hotspots Results included total 1641 publications, with an annual growth rate 25.45%. China United States are leading field, accounting 67.46% 11.27% respectively. The Chinese Academy Sciences Shao D cited institution author, International Journal Nanomedicine journal while Biomaterials highly co-cited journal. Research mainly focus improving drug delivery efficiency, inducing cell apoptosis, photodynamic therapy, photothermal combination treatments. Emerging directions include tumor microenvironment, polyethylene glycol, immunogenic death. Conclusion results gradually becoming area, enhancing therapeutic efficacy, reducing side effects.

Language: Английский

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Revolutionizing healthcare: inorganic medicinal nanoarchitectonics for advanced theranostics

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 10(3), P. 460 - 483

Published: Nov. 22, 2024

Over the last two decades, advancements in nanomaterials and nanoscience have paved path for emergence of nano-medical convergence science, significantly impacting healthcare. In our review, we highlight how these are applied various biomedical technologies such as drug delivery systems, bio-imaging diagnostic therapeutic purposes. Recently, novel inorganic nanohybrid drugs been developed, combining multifunctional with agents (known medicinal nanoarchitectonics). These innovative actively utilized cutting-edge medical treatments, including targeted anti-cancer therapy, photo radiation immunotherapy. This review provides a detailed overview current development status nanoarchitectonics explores potential future directions their advancements.

Language: Английский

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