Peptide Coacervates: Formation, Mechanism, and Biological Applications

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Biomolecular coacervates, dynamic compartments formed via liquid-liquid phase separation (LLPS), are essential for orchestrating intracellular processes and have emerged as versatile tools in bioengineering. Peptides, with their modular amino acid sequences, exhibit unique potential coacervate design due to ability undergo LLPS while offering precise control over molecular architecture environmental responsiveness. Their simplicity, synthetic accessibility, tunability make peptide-based coacervates particularly attractive biomedical materials applications. However, the formation stability of these systems depend on a delicate balance intrinsic factors (e.g., sequence charge, hydrophobicity, chain length) extrinsic conditions pH, ionic strength, temperature), necessitating deeper understanding interplay. This review synthesizes recent advances mechanisms driving peptide coacervation, emphasizing how cues govern behavior. We further highlight groundbreaking applications, from drug delivery platforms protocell mimics, discuss strategies translate mechanistic insights into functional materials. By bridging fundamental principles innovative this work aims accelerate development programmable, multifunctional systems, roadmap next-generation biochemical technologies.

Language: Английский

Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3520 - 3520

Published: July 26, 2024

Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering rich source bioactive compounds with therapeutic potential. However, the clinical application TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, development advanced polymer nanocarriers has emerged promising strategy delivery TCMs. This review focuses on introduction common active recent advancements in design enhancing efficacy safety We begin discussing unique properties inherent associated their delivery. then delve into types polymeric nanocarriers, including micelles, vesicles, hydrogels, drug conjugates, highlighting The main body presents comprehensive analysis state-of-the-art nanocarrier systems introduces impact stability, bioavailability TCM components. On basis this, we provide an outlook future directions underscores transformative potential revolutionizing delivery, pathway to harness full while ensuring modern medical context.

Language: Английский