Expert Opinion on Investigational Drugs,
Journal Year:
2023,
Volume and Issue:
32(7), P. 643 - 654
Published: July 3, 2023
Introduction
Sensorineural
hearing
loss
results
in
irreversible
of
inner
ear
hair
cells
and
spiral
ganglion
neurons.
Reduced
sound
detection
speech
discrimination
can
span
all
ages,
sensorineural
rehabilitation
is
limited
to
amplification
with
aids
or
cochlear
implants.
Recent
insights
into
experimental
drug
treatments
for
regeneration
otoprotection
have
paved
the
way
clinical
trials
order
restore
a
more
physiological
experience.
Paired
development
innovative
minimally
invasive
approaches
delivery
ear,
new,
emerging
protection
restoration
are
within
reach.Areas
covered
This
expert
opinion
provides
an
overview
latest
therapies
protect
from
loss.Expert
The
degree
type
cellular
damage
cochlea,
responsiveness
remaining,
endogenous
regenerative
treatments,
duration
availability
fluids
will
determine
success
restoration.
npj Regenerative Medicine,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Oct. 25, 2022
Mammalian
sensory
hair
cells
(HCs)
have
limited
capacity
for
regeneration,
which
leads
to
permanent
hearing
loss
after
HC
death.
Here,
we
used
in
vitro
RNA-sequencing
show
that
the
Hippo
signaling
pathway
is
involved
damage
and
self-repair
processes.
Turning
off
through
Mst1/2
inhibition
or
Yap
overexpression
induces
YAP
nuclear
accumulation,
especially
supporting
cells,
supernumerary
production
regeneration
injury.
Mechanistically,
these
effects
of
work
synergistically
with
Notch
pathway.
Importantly,
HCs
not
only
express
markers,
but
also
cilia
structures
are
able
form
neural
connections
auditory
regions
vivo.
Taken
together,
regulating
suggests
new
strategies
promoting
cochlear
cell
proliferation,
reconnection
neurons
mammals.
Expert Opinion on Biological Therapy,
Journal Year:
2022,
Volume and Issue:
22(6), P. 689 - 705
Published: April 29, 2022
More
than
5%
of
the
world's
population
have
a
disabling
hearing
loss
which
can
be
managed
by
aids
or
implanted
electrical
devices.
However,
outcomes
are
highly
variable,
and
sound
perceived
recipients
is
far
from
perfect.
Sparked
discovery
progenitor
cells
in
cochlea
rapid
progress
drug
delivery
to
cochlea,
biological
pharmaceutical
therapies
currently
development
improve
function
cochlear
implant
eliminate
need
for
it
altogether.This
review
highlights
emerging
regenerative
strategies
restore
adjunct
augment
implant.
Novel
approaches
include
reprogramming
sensory
hair
cell
gene
therapy,
editing
treat
hereditary
acquired
loss.
A
detailed
optogenetics
also
presented
as
technique
that
could
enable
optical
stimulation
spiral
ganglion
neurons,
replacing
complementing
stimulation.Increasing
evidence
substantial
reversal
animal
models,
alongside
advances
learnings
clinical
trials
will
amalgamate
into
therapy
replace
complement
Development,
Journal Year:
2022,
Volume and Issue:
149(12)
Published: June 15, 2022
ABSTRACT
It
is
well
established
that
humans
and
other
mammals
are
minimally
regenerative
compared
with
organisms
such
as
zebrafish,
salamander
or
amphibians.
In
recent
years,
however,
the
identification
of
potential
in
neonatal
mouse
tissues
normally
heal
poorly
adults
has
transformed
our
understanding
capacity
mammals.
this
Review,
we
survey
mammalian
for
which
improved
healing
been
established,
including
heart,
cochlear
hair
cells,
brain
spinal
cord,
dense
connective
tissues.
We
also
highlight
common
and/or
tissue-specific
mechanisms
regeneration,
involve
signaling
pathways,
extracellular
matrix,
immune
cells
factors.
The
features
across
may
direct
therapeutic
strategies
will
be
broadly
applicable
to
multiple
adult
Genes,
Journal Year:
2023,
Volume and Issue:
14(2), P. 380 - 380
Published: Jan. 31, 2023
The
precise
control
of
neural
crest
stem
cell
delamination,
migration
and
differentiation
ensures
proper
craniofacial
head
development.
Sox2
shapes
the
ontogeny
cranial
to
ensure
precision
flow
in
developing
head.
Here,
we
review
how
orchestrates
signals
that
these
complex
developmental
processes.
Expert Opinion on Investigational Drugs,
Journal Year:
2023,
Volume and Issue:
32(7), P. 643 - 654
Published: July 3, 2023
Introduction
Sensorineural
hearing
loss
results
in
irreversible
of
inner
ear
hair
cells
and
spiral
ganglion
neurons.
Reduced
sound
detection
speech
discrimination
can
span
all
ages,
sensorineural
rehabilitation
is
limited
to
amplification
with
aids
or
cochlear
implants.
Recent
insights
into
experimental
drug
treatments
for
regeneration
otoprotection
have
paved
the
way
clinical
trials
order
restore
a
more
physiological
experience.
Paired
development
innovative
minimally
invasive
approaches
delivery
ear,
new,
emerging
protection
restoration
are
within
reach.Areas
covered
This
expert
opinion
provides
an
overview
latest
therapies
protect
from
loss.Expert
The
degree
type
cellular
damage
cochlea,
responsiveness
remaining,
endogenous
regenerative
treatments,
duration
availability
fluids
will
determine
success
restoration.
