Overview of Cancer Metabolism and Signaling Transduction DOI Open Access
Heesuk Chae, Seong‐Tshool Hong

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 12 - 12

Published: Dec. 20, 2022

Despite the remarkable progress in cancer treatment up to now, we are still far from conquering disease. The most substantial change after malignant transformation of normal cells into is alteration their metabolism. Cancer reprogram metabolism support elevated energy demand as well acquisition and maintenance malignancy, even nutrient-poor environments. metabolic alterations, under aerobic conditions, such upregulation glucose uptake glycolysis (the Warburg effect), increase ROS (reactive oxygen species) glutamine dependence, which prominent features Among these high dependency has attracted serious attention research community. In addition, oncogenic signaling pathways well-known important genetic mutations play regulatory roles, either directly or indirectly, central carbon identification convergent phenotypes crucial targeting cells. this review, investigate relationship between signal transduction pathways, highlight recent developments anti-cancer therapy that target

Language: Английский

Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options DOI Open Access
Piero Portincasa, Mohamad Khalil, Laura Mahdi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5640 - 5640

Published: May 22, 2024

The epidemiological burden of liver steatosis associated with metabolic diseases is continuously growing worldwide and in all age classes. This condition generates possible progression damage (i.e., inflammation, fibrosis, cirrhosis, hepatocellular carcinoma) but also independently increases the risk cardio-metabolic cancer. In recent years, terminological evolution from “nonalcoholic fatty disease” (NAFLD) to “metabolic dysfunction-associated (MAFLD) and, finally, steatotic (MASLD) has been paralleled by increased knowledge mechanisms linking local hepatic) systemic pathogenic pathways. As a consequence, need for an appropriate classification individual phenotypes oriented investigation innovative therapeutic tools. Besides well-known role lifestyle change, number pharmacological approaches have explored, ranging antidiabetic drugs agonists acting on gut–liver axis at level (mainly farnesoid X receptor (FXR) agonists, PPAR thyroid hormone agonists), anti-fibrotic anti-inflammatory agents. intrinsically complex pathophysiological history MASLD makes selection single effective treatment major challenge, so far. this evolving scenario, cooperation between different stakeholders (including subjects risk, health professionals, pharmaceutical industries) could significantly improve management disease implementation primary secondary prevention measures. high healthcare search new, effective, safe pressing need, together accurate characterization phenotypes. Recent promising advances indicate that we may soon enter era precise personalized therapy MASLD/MASH.

Language: Английский

Citations

21
Lipid unsaturation promotes BAX and BAK pore activity during apoptosis DOI Creative Commons
Shashank Dadsena, Rodrigo Cuevas Arenas,

Guilherme de Jesus Vieira

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 3, 2024

Abstract BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, molecular architecture apoptotic pore remains key open question especially little is known about contribution lipids to MOMP. By performing comparative lipidomics analysis proximal environment isolated lipid nanodiscs, we find significant enrichment unsaturated species nearby conditions. We then demonstrate promote activity model membranes, mitochondria cellular systems, which further supported by dynamics simulations. Accordingly, fatty acid desaturase FADS2 not only enhances sensitivity, but also activation cGAS/STING pathway downstream mtDNA release. The correlation levels with sensitization different lung kidney cancer cell lines co-treatment acids supports relevance our findings. Altogether, work provides an insight on how local affects function during apoptosis.

Language: Английский

Citations

21
Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy DOI Creative Commons
Yuting Wu, Xi Pu, Xu Wang

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 1, 2024

Abstract Lipid metabolism in cancer cells has garnered increasing attention recent decades. Cancer thrive hypoxic conditions, nutrient deficiency, and oxidative stress cannot be separated from alterations lipid metabolism. Therefore, exhibit increased metabolism, uptake, lipogenesis storage to adapt a progressively challenging environment, which contribute their rapid growth. Lipids aid cell activation. absorb lipids with the help of transporter translocase proteins obtain energy. Abnormal levels series synthases over-accumulation tumor microenvironment (TME). reprogramming plays an essential role TME. are closely linked several immune phenotypic transformation. The further promotes immunosuppression, leads escape. This event significantly affects progression, treatment, recurrence, metastasis cancer. present review describes TME examines connection between immunotherapy.

Language: Английский

Citations

17
Energy metabolism in health and diseases DOI Creative Commons
Hui Liu, Shuo Wang, Jianhua Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 18, 2025

Language: Английский

Citations

8
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy DOI Creative Commons

Qinglong Ma,

Wenyang Zhang, Kongming Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis fatty acids nucleotides. However, beyond mechanisms KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related alterations cells explore prevalence significance mutation shaping tumor microenvironment influencing epigenetic modification via various molecular activities. Given rely these changes sustain cell growth survival, targeting processes may represent a promising therapeutic strategy for KRAS-driven cancers.

Language: Английский

Citations

4
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation DOI
Lei Wang,

Runze Shi,

Shuo Wang

et al.

Nature Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

2
Regulation of osteoclast-mediated bone resorption by lipids DOI

Fang Luo,

Tianyi Chen, Song Chen

et al.

Bone, Journal Year: 2025, Volume and Issue: 193, P. 117423 - 117423

Published: Feb. 9, 2025

Language: Английский

Citations

2
Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer DOI Creative Commons
Hao Zhang, Yuan Tian, Chunjie Xu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 26, 2025

Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.

Language: Английский

Citations

2
Nanomedicines Targeting Metabolic Pathways in the Tumor Microenvironment: Future Perspectives and the Role of AI DOI Creative Commons

Shuai Fan,

Wenyu Wang,

Wieqi Che

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 201 - 201

Published: March 13, 2025

Background: Tumor cells engage in continuous self-replication by utilizing a large number of resources and capabilities, typically within an aberrant metabolic regulatory network to meet their own demands. This dysregulation leads the formation tumor microenvironment (TME) most solid tumors. Nanomedicines, due unique physicochemical properties, can achieve passive targeting certain tumors through enhanced permeability retention (EPR) effect, or active deliberate design optimization, resulting accumulation TME. The use nanomedicines target critical pathways holds significant promise. However, requires careful selection relevant drugs materials, taking into account multiple factors. traditional trial-and-error process is relatively inefficient. Artificial intelligence (AI) integrate big data evaluate delivery efficiency nanomedicines, thereby assisting nanodrugs. Methods: We have conducted detailed review key papers from databases, such as ScienceDirect, Scopus, Wiley, Web Science, PubMed, focusing on reprogramming, mechanisms action development metabolism, application AI empowering nanomedicines. integrated content present current status research metabolism potential future directions this field. Results: Nanomedicines possess excellent TME which be utilized disrupt cells, including glycolysis, lipid amino acid nucleotide metabolism. disruption selective killing disturbance Extensive has demonstrated that AI-driven methodologies revolutionized nanomedicine development, while concurrently enabling precise identification molecular regulators involved oncogenic reprogramming pathways, catalyzing transformative innovations targeted cancer therapeutics. Conclusions: great Additionally, will accelerate discovery metabolism-related targets, empower optimization help minimize toxicity, providing new paradigm for development.

Language: Английский

Citations

2
Role of hypoxia in the tumor microenvironment and targeted therapy DOI Creative Commons

Gaoqi Chen,

Kaiwen Wu, Hao Li

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Sept. 23, 2022

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid tumors. As a current research hotspot the TME, hypoxia expected to become key element break through bottleneck of tumor treatment. More and more results show that variety biological behaviors cells are affected many factors TME closely related hypoxia. In order inhibiting immune response plays an important role cell metabolism anti-apoptosis. Therefore, exploring molecular mechanism mediated malignant behavior therapeutic targets provide new ideas for anti-tumor therapy. this review, we discussed effects on its interaction with from perspectives cells, metabolism, oxidative stress inducible factor (HIF), listed or signal pathways found so far. Finally, summarize therapies targeting such as glycolysis inhibitors, anti-angiogenesis drugs, HIF hypoxia-activated prodrugs, hyperbaric medicine.

Language: Английский

Citations

66