Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies – A stakeholder meeting report DOI Creative Commons
Irina Meln, Victor M. Cnossen, Nicoletta Corti

et al.

Biologicals, Journal Year: 2025, Volume and Issue: 90, P. 101818 - 101818

Published: Jan. 17, 2025

Language: Английский

Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study DOI Creative Commons
Sho Nakakubo,

Naoki Kishida,

Kenichi Okuda

et al.

The Lancet Infectious Diseases, Journal Year: 2023, Volume and Issue: 23(11), P. 1244 - 1256

Published: June 30, 2023

Language: Английский

Citations

31
Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion DOI Creative Commons
Tabea M. Eser,

Olga Baranov,

Manuel Huth

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 24, 2023

Abstract Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components early immune response protect against development severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis nasopharyngeal peripheral blood samples obtained during acute phase infection with SARS-CoV-2. We find that soluble transcriptional markers systemic inflammation peak first week after symptom onset correlate directly upper airways viral loads (UA-VLs), whereas contemporaneous frequencies circulating nucleocapsid (NC)-specific CD4 + CD8 T cells inversely various inflammatory UA-VLs. In addition, show high activated are present in acutely infected tissue, many express genes encoding effector molecules, such as cytotoxic proteins IFN-γ. The presence IFNG mRNA-expressing epithelium is further linked common patterns gene expression among virus-susceptible target better local control Collectively, these results identify an protection could inform more effective vaccines to combat chronic illnesses attributable

Language: Английский

Citations

24
Broad-spectrum pan-genus and pan-family virus vaccines DOI Creative Commons
Chee Wah Tan, Sophie Valkenburg, Leo L. M. Poon

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(6), P. 902 - 916

Published: June 1, 2023

Language: Английский

Citations

24
Silent battles: immune responses in asymptomatic SARS-CoV-2 infection DOI
Nina Le Bert, Taraz Samandari

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(2), P. 159 - 170

Published: Jan. 15, 2024

Language: Английский

Citations

9
Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies – A stakeholder meeting report DOI Creative Commons
Irina Meln, Victor M. Cnossen, Nicoletta Corti

et al.

Biologicals, Journal Year: 2025, Volume and Issue: 90, P. 101818 - 101818

Published: Jan. 17, 2025

Language: Английский

Citations

1