Occurrence, evaluation, and human health risk assessment of ochratoxin a in infant formula and cereal-based baby food: a global literature systematic review DOI
Mohammad Shakil Ahmad, Yousef Abud Alanazi,

Yousef Alrohaimi

et al.

Food Additives & Contaminants Part A, Journal Year: 2024, Volume and Issue: 41(9), P. 1171 - 1186

Published: July 15, 2024

This study reviews global levels of ochratoxin A (OTA) in infant formula and cereal-based foods, using Monte Carlo simulation to assess risks. The review found 24 studies on OTA food products, databases including PubMed, Scopus, Web Science Embase until March 2024. We estimated exposure based concentration, intake body weight. hazard quotient margin were calculated BMDL10 TDI values. evaluated human health risks from foods. 14 countries shows varying levels, surpassing EU limits Tunisia, Ecuador, the USA, generally Africa, notably cereals, which had higher than formula. Globally, was present 29.3% 3348 samples analyzed, with Lebanon at 95.2% Brazil 0%. Analysis indicates only non-carcinogenic risk for infants. While infants are mostly low, ongoing research monitoring vital minimize food.

Language: Английский

Prosopis farcta biochar neutralizes aflatoxin B1 and enhances health and productivity in quails DOI Creative Commons

Majid Raz,

Farzad Bagherzadeh Kasmani, Mohammad Amir Karimi Torshizi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: March 11, 2025

Language: Английский

Citations

1
Natural Phenolic Compounds against Trichothecenes: From Protective Mechanisms to Future Perspectives DOI
Aimei Liu, Kan Zhu,

Chenchen Song

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Trichothecenes (TCNs), Fusarium-derived mycotoxins exemplified by deoxynivalenol and T-2 toxin, threaten global health through multisystem toxicity widespread contamination. Natural phenolic compounds (NPCs), leveraging their intrinsic safety natural abundance, demonstrate multimechanistic efficacy in counteracting TCN toxicity. This article reviews both domestic international research on the protective mechanisms of NPCs against TCN-induced exert effects multitiered mechanisms: (1) molecular regulation via Nrf2-centric antioxidant activation MAPK/NF-κB inflammatory axis suppression, coupled with coordinated inhibition programmed cell death pathways (apoptosis/ferroptosis/pyroptosis) autophagy modulation, where GPX4 emerges as a critical ferroptosis regulator; (2) restoring microbiome balance, enhancing intestinal barrier function, optimizing nutrient transport. Gut microflora may also serve an additional target for mitigating TCNs. further inhibit Fusarium proliferation mycotoxin biosynthesis. While there is demonstrated potential food sustainable feed development, challenges persist bioavailability optimization, pharmacokinetic profiling, microbiota-metabolite crosstalk. analysis advances NPC-based strategies detoxification agriculture.

Language: Английский

Citations

0
T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks DOI Creative Commons

Keying An,

Bozhi Shi,

Xueze Lv

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117169 - 117169

Published: Oct. 12, 2024

Language: Английский

Citations

2
Occurrence, evaluation, and human health risk assessment of ochratoxin a in infant formula and cereal-based baby food: a global literature systematic review DOI
Mohammad Shakil Ahmad, Yousef Abud Alanazi,

Yousef Alrohaimi

et al.

Food Additives & Contaminants Part A, Journal Year: 2024, Volume and Issue: 41(9), P. 1171 - 1186

Published: July 15, 2024

This study reviews global levels of ochratoxin A (OTA) in infant formula and cereal-based foods, using Monte Carlo simulation to assess risks. The review found 24 studies on OTA food products, databases including PubMed, Scopus, Web Science Embase until March 2024. We estimated exposure based concentration, intake body weight. hazard quotient margin were calculated BMDL10 TDI values. evaluated human health risks from foods. 14 countries shows varying levels, surpassing EU limits Tunisia, Ecuador, the USA, generally Africa, notably cereals, which had higher than formula. Globally, was present 29.3% 3348 samples analyzed, with Lebanon at 95.2% Brazil 0%. Analysis indicates only non-carcinogenic risk for infants. While infants are mostly low, ongoing research monitoring vital minimize food.

Language: Английский

Citations

0