Reproductive Benefits of Dietary Selenium Nanoparticles (SeNPs) in Asian Seabass (Lates calcarifer) Male Broodstock
Marine Biotechnology,
Journal Year:
2025,
Volume and Issue:
27(1)
Published: Feb. 1, 2025
Language: Английский
Changes in Cerebrospinal Fluid Concentrations of Selenium Species Induced by Tofersen Administration in Subjects with Amyotrophic Lateral Sclerosis Carrying SOD1 Gene Mutations
Biological Trace Element Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 17, 2024
Amyotrophic
lateral
sclerosis
(ALS)
is
a
fatal
neurodegenerative
disease
affecting
the
brain
and
spinal
cord
motor
neurons.
On
25
April
2023,
drug
tofersen,
an
antisense
oligonucleotide,
received
US
Food
Drug
Administration
approval
for
treating
ALS
in
adults
carrying
mutations
of
SOD1
gene.
We
aimed
at
assessing
whether
cerebrospinal
fluid
concentrations
selenium,
element
both
toxicological
nutritional
interest
possibly
involved
etiology
progression,
are
modified
by
tofersen
administration.
determined
selenium
species
anion
exchange
chromatography
hyphenated
to
inductively
coupled
plasma-dynamic
reaction
cell-mass
spectrometry
overall
using
plasma
sector-field
mass
spectrometry,
baseline
6
months
after
active
treatment
ten
Italian
patients
gene
mutation.
Concentrations
total
many
substantially
increased
intervention,
particularly
inorganic
(tetravalent
hexavalent)
organic
selenomethionine
compound
co-eluting
with
selenocystine
standard.
Overall,
these
findings
suggest
that
markedly
alters
status
probably
redox
within
central
nervous
system,
due
direct
effect
on
neurons
and/or
blood-brain
barrier.
Further
studies
required
investigate
biological
clinical
relevance
how
they
might
relate
pharmacological
effects
progression.
Language: Английский
Selenium Treatment Ameliorates the Adverse Effects Caused by Dynamin Gene Knockdown in Bombyx mori
Archives of Insect Biochemistry and Physiology,
Journal Year:
2024,
Volume and Issue:
117(1)
Published: Sept. 1, 2024
ABSTRACT
Our
previous
research
reported
the
influence
of
50
μM
selenium
(Se)
on
cytosolization
(endocytosis)
pathway,
which
in
turn
stimulates
growth
and
development
Bombyx
mori
.
Lately,
dynamin
is
recognized
as
one
key
proteins
endocytosis.
To
explore
underlying
mechanisms
Se
impact,
gene
was
knocked
down
by
injecting
siRNAs
(
Dynamin‐1
,
Dynamin‐2
Dynamin‐3
).
This
followed
an
analysis
target
levels
silk
protein
genes,
well
developmental
indices,
Se‐enrichment
capacity,
degree
oxidative
damage,
antioxidant
capacity
B.
findings
showed
a
considerable
decrease
relative
expression
all
tissues
24
h
after
interference
dramatic
silkworm
body
48
h.
RNAi
decreased
weight,
cocoon
shell
ratio
cocoon.
In
meantime,
malondialdehyde
level
increased
glutathione
superoxide
dismutase/catalase
activities
decreased.
markedly
ameliorated
these
physiological
deficits
decreases
expression.
On
other
hand,
there
were
no
significant
effects
fertility
(including
produced
eggs
laid
eggs)
between
treatments.
Additionally,
content
interference.
The
highly
expressed
gland
declined
significantly
Among
three
),
dynamin‐2
displayed
highest
to
results
demonstrated
that
effective
prevent
any
adverse
caused
knockdown
silkworms.
provides
practical
implications
for
B
breeding
industry.
Language: Английский
Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)
Cardiovascular Toxicology,
Journal Year:
2024,
Volume and Issue:
24(11), P. 1287 - 1300
Published: Aug. 30, 2024
Cardiovascular
diseases
are
a
rampant
public
health
threat.
Environmental
contaminants,
such
as
Cadmium
(Cd),
toxic
metal,
risk
factors
for
cardiovascular
diseases.
Given
that
human
exposure
to
Cd
is
increasing,
there
need
therapies
ameliorate
toxicity.
Selenium
(Se),
an
essential
trace
element,
has
been
proposed
rescue
the
effects
of
toxicity,
with
mixed
effects.
Se's
narrow
therapeutic
window
necessitates
precise
dosing
avoid
Here,
we
assessed
various
waterborne
and
Se
concentrations
sequences
on
cardiac
function
using
zebrafish
(Danio
rerio).
We
showed
induced
pericardial
edemas
modified
heart
rates
in
larvae
concentration-dependent
manner.
To
identify
range
Cd-induced
cardiotoxicity,
embryos
were
treated
0,
10,
50,
100,
150,
or
200
μg/L
1-4
days
prior
2.5
5
Cd.
found
50
µg/L
pre-treatment
before
Cd,
but
not
reduced
prevalence
ameliorated
bradycardia
zebrafish.
Zebrafish
exposed
10
up
4
typical
morphology,
whereas
other
Se-exposed
control
fish
presented
edemas.
Longer
durations
led
fewer
incidences
Overall,
this
study
highlights
importance
optimizing
periods
harness
its
protective
against
cardiotoxicity.
These
findings
provide
insights
into
potential
strategies
reducing
Cd-related
damage
humans.
Language: Английский