Exploring the synergy of artificial intelligence in microbiology: Advancements, challenges, and future prospects

Deleted Journal, Journal Year: 2024, Volume and Issue: 1, P. 100005 - 100005

Published: June 1, 2024

The integration of artificial intelligence (AI) into microbiology has the transformative potential to advance our understanding and treatment microbial systems. This review examines various applications AI in microbiology, including activities such as predicting drug targets vaccine candidates, identifying microorganisms responsible for infectious diseases, classifying resistance antimicrobial drugs, disease outbreaks, well investigating interactions between microorganisms, quality assurance, Identification bacteria compliance with health standards. We summarized key algorithms Naive Bayes, Support Vector Machines, Deep Learning, Random Forests used microbiological studies. also address challenges criticisms associated microbiology. Finally, we discuss prospects AI, advances personalized medicine, reducing resistance, microbiome research, rapid diagnostics, environmental synthetic biology. Our includes a comprehensive analysis recent literature, evaluating research. systematic searches inclusion criteria ensure relevance reviewed Despite significant that brings data heterogeneity, model transparency, ethical considerations must be addressed. Interdisciplinary collaboration rigorous validation models are crucial overcome these challenges. future looks promising pathogen detection, monitoring. provides powerful tool revolutionize diagnosis, ecosystems.

Language: Английский

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Understanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animals

Virulence, Journal Year: 2021, Volume and Issue: 12(1), P. 2777 - 2786

Published: Oct. 26, 2021

Several animal species, including ferrets, hamsters, monkeys, and raccoon dogs, have been shown to be susceptible experimental infection by the human severe acute respiratory syndrome coronaviruses, such as SARS-CoV SARS-CoV-2, which were responsible for 2003 SARS outbreak 2019 coronavirus disease (COVID-19) pandemic, respectively. Emerging studies that SARS-CoV-2 natural of pet dogs cats is also possible, but its prevalence not fully understood. Experimentally, it has demonstrated replicates more efficiently in than can transmit virus through aerosols. With approximately 470 million 370 cohabitating with their owners worldwide, finding these household pets important implications potential zoonotic transmission events during COVID-19 pandemic well future SARS-related outbreaks. Here, we describe some ongoing worldwide surveillance efforts assess exposure companion, captive, wild, farmed animals, provide perspectives on intra- inter-species transmissions, evolution, human-animal interface along public health. Some develop implement a new vaccine animals are discussed. Surveillance initiatives track exposures necessary accurately determine impact veterinary health, define reservoir sources evolutionary dynamics.

Language: Английский

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Exceptional diversity and selection pressure on coronavirus host receptors in bats compared to other mammals

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 289(1979)

Published: July 27, 2022

Pandemics originating from non-human animals highlight the need to understand how natural hosts have evolved in response emerging human pathogens and which groups may be susceptible infection and/or potential reservoirs mitigate public health conservation concerns. Multiple zoonotic coronaviruses, such as severe acute respiratory syndrome-associated coronavirus (SARS-CoV), SARS-CoV-2 Middle Eastern (MERS-CoV), are hypothesized bats. We investigate angiotensin-converting enzyme 2 (ACE2), host protein bound by SARS-CoV SARS-CoV-2, dipeptidyl-peptidase 4 (DPP4 or CD26), MERS-CoV, largest bat datasets date. Both ACE2 DPP4 genes under strong selection pressure bats, more so than other mammals, residues that contact viruses. Additionally, mammalian vary their similarity humans SARS-CoV, increased binding is broadly predictive of susceptibility SARS-CoV-2. This work augments our understanding relationship between coronaviruses particularly provides taxonomically diverse data for studies proteins can inform surveillance, efforts.

Language: Английский

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SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City

Viruses, Journal Year: 2022, Volume and Issue: 14(12), P. 2770 - 2770

Published: Dec. 12, 2022

There is mounting evidence of SARS-CoV-2 spillover from humans into many domestic, companion, and wild animal species. Research indicates that have infected white-tailed deer, deer-to-deer transmission has occurred, indicating deer could be a wildlife reservoir source novel variants. We examined the hypothesis Omicron variant actively asymptomatically infecting free-ranging New York City. Between December 2021 February 2022, 155 on Staten Island, York, were anesthetized for gross abnormalities illnesses. Paired nasopharyngeal swabs blood samples collected analyzed presence RNA antibodies. Of 135 serum samples, 19 (14.1%) indicated exposure, 11 reacted most strongly to wild-type B.1 lineage. 71 swabs, 8 positive (4 4 Delta). Two animals had active infections robust neutralizing antibodies, revealing reinfection or early seroconversion in deer. Variants concern continue circulate among may reinfect US populations, establish enzootic cycles wild: this warrants coordinated One Health response, proactively surveil, identify, curtail variants before they can spill back humans.

Language: Английский

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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

PLoS Pathogens, Journal Year: 2023, Volume and Issue: 19(4), P. e1011206 - e1011206

Published: April 5, 2023

Investigation of potential hosts the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks spillover and spillback. SARS-CoV-2 has been reported be transmitted from humans various animals after requiring relatively few mutations. There significant interest in describing how virus interacts with mice as they are well adapted human environments, used widely infection models can infected. Structural binding data mouse ACE2 receptor Spike protein newly identified variants needed better understand impact immune system evading mutations present concern (VOC). Previous studies have developed mouse-adapted residues critical for heterologous receptors. Here we report cryo-EM structures bound trimeric ectodomains four different VOC: Beta, Omicron BA.1, BA.2.12.1 BA.4/5. These represent oldest newest known bind receptor. Our high-resolution structural complemented bio-layer interferometry (BLI) assays reveal a requirement combination that enable

Language: Английский

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One Health for All: Advancing Human and Ecosystem Health in Cities by Integrating an Environmental Justice Lens

Annual Review of Ecology Evolution and Systematics, Journal Year: 2022, Volume and Issue: 53(1), P. 403 - 426

Published: Sept. 2, 2022

We are facing interwoven global threats to public health and ecosystem function that reveal the intrinsic connections between human wildlife health. These challenges especially pressing in cities, where social-ecological interactions pronounced. The One Health concept provides an organizing framework promotes well-being of urban communities ecosystems. However, for be successful, it must incorporate societal inequities environmental disamenities, exposures, policy. Such affect all interfaces, including distribution services disservices, nature frequency ofhuman–wildlife interactions, legacies land use. Here, we review current literature on perspectives, pinpoint areas which justice lens, close with recommendations future work. Intensifying social, political, unrest underscores a dire need solutions informed by principles help build healthier, more resilient cities.

Language: Английский

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Molecular adaptations during viral epidemics

EMBO Reports, Journal Year: 2022, Volume and Issue: 23(8)

Published: July 18, 2022

Language: Английский

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Drug repurposing for identification of potential spike inhibitors for SARS-CoV-2 using molecular docking and molecular dynamics simulations

Methods, Journal Year: 2022, Volume and Issue: 203, P. 498 - 510

Published: Feb. 12, 2022

For the last two years, COVID-19 pandemic has continued to bring consternation on most of world. According recent WHO estimates, there have been more than 5.6 million deaths worldwide. The virus continues evolve all over world, thus requiring both vigilance and necessity find develop a variety therapeutic treatments, including identification specific antiviral drugs. Multiple studies confirmed that SARS-CoV-2 utilizes its membrane-bound spike protein recognize human angiotensin-converting enzyme 2 (ACE2). Thus, preventing spike-ACE2 interactions is potentially viable strategy for treatment as it would block from binding entering into host cell. This work aims identify potential drugs using an in silico approach. Molecular docking was carried out approved substances previously tested vivo. step followed by detailed analysis selected ligands molecular dynamics simulations best molecules thwart ability interact with ACE2 receptor. Because evolves rapidly due plethora immunocompromised hosts, compounds were against five different known lineages. As result, we could well individual lineages those showing broader efficacy. promising candidates among currently used zafirlukast simeprevir average affinity -22 kcal/mol proteins originating various first compound leukotriene receptor antagonist treat asthma, while latter protease inhibitor hepatitis C treatment. From vivo concurrently exhibit free energy ADME parameters (indicating possible oral administration) BDBM50136234. In conclusion, these are worth exploring further vitro SARS-CoV-2.

Language: Английский

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Susceptibility of Wild Canids to SARS-CoV-2

Emerging infectious diseases, Journal Year: 2022, Volume and Issue: 28(9), P. 1852 - 1855

Published: July 22, 2022

We assessed 2 wild canid species, red foxes (Vulpes vulpes) and coyotes (Canis latrans), for susceptibility to SARS-CoV-2. After experimental inoculation, became infected shed infectious virus. Conversely, experimentally challenged did not become infected; therefore, are unlikely be competent hosts

Language: Английский

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SARS-CoV-2 Infection in Captive Hippos (Hippopotamus amphibius), Belgium

Animals, Journal Year: 2023, Volume and Issue: 13(2), P. 316 - 316

Published: Jan. 16, 2023

Two adult female hippos in Zoo Antwerp who were naturally infected with SARS-CoV-2 showed nasal discharge for a few days. Virus was detected by immunocytochemistry and PCR swab samples faeces pool water. Serology also positive. No treatment necessary.

Language: Английский

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