Implementation of Blockchain Technology Could Increase Equity and Transparency in Organ Transplantation: A Narrative Review of an Emergent Tool

Transplant International, Journal Year: 2023, Volume and Issue: 36

Published: Feb. 8, 2023

In the last few years, innovative technology and health care digitalization played a major role in all medical fields great effort worldwide to manage this large amount of data, terms security digital privacy has been made by different national systems. Blockchain technology, peer-to-peer distributed database without centralized authority, initially applied Bitcoin protocol, soon gained popularity, thanks its immutable nature several non-medical fields. Therefore, aim present review (PROSPERO N° CRD42022316661) is establish putative future blockchain distribution ledger (DLT) organ transplantation field overcome inequalities. Preoperative assessment deceased donor, supranational crossover programs with international waitlist databases, reduction black-market donations counterfeit drugs are some possible applications DLT, distributed, efficient, secure, trackable, reduce inequalities discrimination.

Language: Английский

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The respiratory syncytial virus vaccines are here: Implications for solid organ transplantation

American Journal of Transplantation, Journal Year: 2024, Volume and Issue: 24(6), P. 897 - 904

Published: Feb. 8, 2024

Language: Английский

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Comparison of Short-Term Outcomes in Kidney Transplant Recipients from SARS-CoV-2–Infected versus Noninfected Deceased Donors

Clinical Journal of the American Society of Nephrology, Journal Year: 2023, Volume and Issue: 18(11), P. 1466 - 1475

Published: Aug. 14, 2023

Acceptable post-transplant outcomes were reported in kidney transplant recipients from donors with coronavirus disease 2019 (COVID-19); however, there are no comparative studies well-matched controls.

Language: Английский

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Update on Covid-19: vaccines, timing of transplant after COVID-19 infection and use of positive donors

Current Opinion in Organ Transplantation, Journal Year: 2023, Volume and Issue: 28(2), P. 76 - 84

Published: Feb. 15, 2023

Purpose of review SARS-CoV-2 resulted in a global pandemic that had chilling effect on transplantation early the and continues to result significant morbidity mortality transplant recipients. Over past 2.5 years, our understanding clinical utility vaccination mAbs prevent COVID-19 solid organ (SOT) recipients has been studied. Likewise, approach donors candidates with better understood. This will attempt summarize current these important topics. Recent findings Vaccination against is effective reducing risk severe disease death among patients. Unfortunately, humoral and, lesser extent, cellular immune response existing vaccines reduced SOT compared healthy controls. Additional doses vaccine are required optimize protection this population still may be insufficient those who highly immunosuppressed, receiving belatacept, rituximab other B-cell active mAbs. Until recently, were options for prevention but markedly less recent omicron variants. SARS-CoV-2-infected can generally used nonlung, nonsmall bowel transplants unless they have died acute or COVID-19-associated clotting disorders. Summary Our require three-dose mRNA adenovirus-vector one dose optimally protected initially; then need receive bivalent booster 2+ months after completing their initial series. Most utilized as donors.

Language: Английский

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Favorable experience of transplant strategy including liver grafts from COVID‐19 donors: One‐year follow‐up results

Transplant Infectious Disease, Journal Year: 2023, Volume and Issue: 25(5)

Published: Aug. 16, 2023

Since November 2020, Italy was the first country to carry out a protocol and use liver from COVID-19 donors. We aimed evaluate medium-term outcome of patients who underwent transplant (LT) with those grafts.We consecutively enrolled 283 LT 2020 December 2022 in our Center (follow-up 468 days). Twenty-five (8.8%, study population) received graft donors previous (4%) or active (96%) SARS-CoV-2 infection, 258/283 (91.2%, control group) COVID-19-negative SARS-CoV-2-RNA tested on tissue their recipients weekly evaluation nasal swabs for month after LT.One-year 2-year patient survival 88.5% group versus 94.5% 93.5% group, respectively (p = .531). In population there no evidence donor-recipient virus transmission, but three (12%) (vs. 7 [2.7%] p .048) developed hepatic artery thrombosis (HAT): they were negative at 1/3 grafts positive tissue. donor independently associated HAT (odds ratio (OR) 4.85, 95% confidence interval (CI) 1.10-19.15; .037). By comparing acute rejection biliary complication rates not significantly different (16% vs. 8.1%, .26; 16% 16.3% .99, respectively).Our 1-year results strategy including favorable. only higher rate transplanted compared group.

Language: Английский

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Updates in Kidney Transplantation From the 2022 Banff-Canadian Society of Transplantation Joint Meeting: Conference Report

Canadian Journal of Kidney Health and Disease, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

The 2022 Banff-Canadian Society of Transplantation Meeting in Banff, Alberta, brought together transplant professionals to review new developments across various aspects solid organ transplantation (SOT) Canada.Presentations included consensus recommendations from expert-led forums; experiences with procedures and legislation; reports public health data repositories; original clinical laboratory research; industry updates regarding novel technologies. Speakers referenced articles published peer-reviewed journals online, unpublished preliminary findings.All authors attended presentations in-person or virtually. Recordings select were available for later review. Summaries emphasize concepts indicated by speakers as clinically relevant.The COVID-19 pandemic disproportionately affected recipients (SOTRs), who experience worse outcomes infection than the general population. Vaccinations demonstrate an attenuated immunological response SOTRs yet provide meaningful protection. Monoclonal antibodies are effective both passive immunization treatment SOTRs. Infection control protocols have driven development virtual methods research, such using home blood draws follow-up evaluate vaccine efficacy SOTRs; patient care delivery, employing telerehabilitation post transplant. Access living kidney donation is limited disincentives experienced potential donors, which may be overcome more efficient evaluations including a One-Day Living Kidney Donor Assessment Clinic. International Donation Legislative Policy Forum provided means establishing guidance (ODT) program policy standardize delivery jurisdictions. implementation deemed consent model tissue Nova Scotia insight whether this indeed improves access organs. Canada's Indigenous population unique barriers transplantation, prompting efforts inclusive ODT policy-making. Pan-Canadian Data Performance Reporting System Project has defined performance quality indicators, iTransplant other point-of-care software solutions facilitate collection; however, these endeavors ultimately require information technology infrastructure that exceeds capabilities existing Canadian Organ Replacement Register Transplant Registry. Pig-to-human xenotransplantation requires genetic modification pigs xenoantibody testing but prove viable. Serum cell-free DNA, urine biomarkers, markers offer alternative routine biopsy identifying subclinical rejection. Modified perfusion temperatures hydrogen sulfide donor compounds improve preservation. Molecular compatibility tools another improving SOTR outcomes, Genome Canada Consortium been examining important considerations their implementation.We unable capture all topics at meeting due sizable quantity variety. Topics excluded summary include those pathology Banff Classification updates; extra-renal SOT; well numerous abstract poster presentations, allied provider forums, business meetings. A portion material was presented prior peer-review publication.The conference summarized report identify individual clinicians provincial programs access, SOT Canada, while additionally gaps literature investigators encouraged pursue.En 2022, le congrès annuel de la Société canadienne qui s’est tenu à (Alberta) réuni des professionnels se sont penchés sur les nouveaux développements dans divers d’organes solides (TOS) au Canada.Les présentations portaient notamment : recommandations consensuelles issues forums dirigés par experts; l’expérience avec nouvelles procédures et lois; rapports provenant dépôts données santé publique; recherches cliniques laboratoire originales; mises jour du secteur Les intervenants ont fait référence publiés en ligne revues évaluées pairs, ainsi qu’à non publiées conclusions préliminaires.Tous auteurs assisté aux personne ou virtuellement. enregistrements certaines étaient disponibles pour visionnement ultérieur. résumés mettent l’accent jugés comme cliniquement pertinents intervenants.La pandémie affecté receveurs d’une d’organe solide (RTOS) manière disproportionnée; ces derniers ayant suivi une évolution plus défavorable que générale suite COVID-19. La vaccination, bien qu’elle offre protection significative, montre réponse immunologique faible chez RTOS. anticorps monoclonaux efficaces fois l’immunization traitement protocoles contrôle infections mené développement méthodes virtuelles recherche clinique (p. ex. prélèvements sanguins domicile, virtuel évaluer l’efficacité vaccin RTOS) prestation soins patients rééducation distance) après transplantation. L’accès don rein vivant est limité facteurs dissuasifs donneurs potentiels, mais obstacles peuvent être surmontés évaluations efficaces, d’un candidature vivants rein. Le législatif politique international fourni un moyen d’établir lignes directrices dons (DOT), l’objectif normaliser juridiction l’autre. mise œuvre Nouvelle-Écosse consentement présumé tissus pourrait aider déterminer si tel modèle améliore effectivement l’accès organes. populations autochtones confrontées uniques matière ce encourage visant l’élaboration politiques inclusives DOT. Projet système pancanadien mesure DOT défini indicateurs performance, dont d’autres logicielles points soins, faciliter collecte données; nécessitent toutefois informatique dépasse capacités Registre canadien insuffisances transplantations xénogreffe porc humain requiert génétique porcs dépistage xénoanticorps receveurs, elle peut encore s’avérer L’ADN acellulaire sérique, biomarqueurs urinaires marqueurs génétiques offrent biopsie identifier rejets subcliniques. Des températures modifiées contenant composés générateurs sulfure d’hydrogène améliorer conservation outils compatibilité moléculaire autre d’améliorer résultats RTOS, examiné importants prendre considération leur œuvre.Nous n’avons pas été d’assister toutes raison grand nombre grande diversité sujets abordés. exclus résumé incluent pathologie, classification Banff; propres TOS extrarénale; nombreux d’affiches, prestataires alliés réunions d’affaires. Une partie matériel présenté l’a avant l’examen pairs publication.Les résumées présent rapport identifient provinciaux cliniciens pourraient employer l’accès, qualité soulignent lacunes littérature chercheurs encouragés creuser.

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The learning curve of COVID-19 and organ donation: Potential missed opportunities in the COVID era

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32086 - e32086

Published: May 31, 2024

Early in the COVID-19 pandemic, positive status often disqualified potential organ donors due to perceived risks, despite limited evidence. Subsequent studies have clarified that of donors, particularly when incidental and not cause death, does adversely affect non-lung transplant outcomes. This study quantifies loss eligible corresponding impact on availability during initial phase pandemic.

Language: Английский

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Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization

Transplantation Direct, Journal Year: 2024, Volume and Issue: 10(4), P. e1590 - e1590

Published: March 7, 2024

Background. The COVID-19 pandemic has led to an increase in SARS-CoV-2–test positive potential organ donors. benefits of life-saving liver transplantation (LT) must be balanced against the risk donor-derived viral transmission. Although emerging evidence suggests that use COVID-19–positive donor organs may safe, granular series thoroughly evaluating safety are still needed. Results 29 consecutive LTs from donors at a single center presented here. Methods. A retrospective cohort study LT recipients between April 2020 and December 2022 was conducted. Differences (n = total; 25 index, 4 redo) COVID-19–negative 472 454 18 deceased grafts were compared. Results. significantly younger ( P 0.04) had lower kidney profile indices than Recipients older but otherwise similar negative Donor SARS-CoV-2 infection status not associated with overall survival (hazard ratio, 1.11; 95% confidence interval, 0.24-5.04; 0.89). There 3 deaths among No death seemed virally mediated because there no qualitative association peri-LT antispike antibody titers, post-LT prophylaxis, or variants. Conclusions. utilization decreased recipients. suggestion transmission recipient. results this large single-center suggest used safely expand pool.

Language: Английский

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IPNA clinical practice recommendations on care of pediatric patients with pre-existing kidney disease during seasonal outbreak of COVID-19

Pediatric Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

The coronavirus disease 2019 (COVID-19) pandemic, instigated by the severe acute respiratory syndrome 2 (SARS-CoV-2), has profoundly impacted healthcare infrastructures around globe. While children are usually asymptomatic or have mild symptoms, with pre-existing kidney conditions require specialized attention. This pivotal report, championed International Pediatric Nephrology Association (IPNA), delivers precise and actionable recommendations tailored for pediatric patients ailments in this pandemic landscape. Central to our findings rigorous infection control protocols. These particularly stringent high-risk zones, emphasizing telehealth's indispensable role, significance of curtailing in-person consultations, imperative following guidelines regions heightened COVID-19 prevalence. Additionally, report delves into vaccination approaches issues, highlighting that choice vaccine is often governed regional accessibility policy frameworks, rather than a universal preference. A notable observation potential correlation between vaccines specific disorders. However, establishing direct causal link remains elusive. In summary, research accentuates critical need care during global health crises reaffirms continuous imperative, especially regarding ramifications.

Language: Английский

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Utilization and discard of organs from donors with COVID‐19 in the United States

Clinical Transplantation, Journal Year: 2022, Volume and Issue: 37(3)

Published: Dec. 24, 2022

Language: Английский

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