Unnecessary Use of Corticosteroids for managing early mild symptoms of COVID-19 may lead to Rhino-ortibal-cerebral mucormycosis in Patients with Diabetes – a case series from Lahore, Pakistan DOI Creative Commons
Somia Iqtadar,

Masooma Hashmat,

Muhammad Nabeel Akbar Chaudhry

et al.

Therapeutic Advances in Infectious Disease, Journal Year: 2022, Volume and Issue: 9, P. 204993612210974 - 204993612210974

Published: Jan. 1, 2022

Rhino-orbital-cerebral mucormycosis (ROCM), a rare but fatal fungal infection, has recently emerged as serious complication after corticosteroids therapy in COVID-19 patients, predominantly diabetic and immunocompromised patients. The World Health Organization (WHO) current guidelines recommend administration hospitalized patients requiring supplementary oxygen or mechanical ventilation. Herein, we report case series of seven with COVID-19; three mild, moderate, one severe, from Lahore, Pakistan; all were using for managing their early mild symptoms at home around 2–3 weeks without physician’s advise, presented, admitted ROCM to Mayo hospital, March June 2021. Out the five had uncontrolled diabetes mellitus (DM) comorbidity. Eye pain, facial swelling nasal blockage, black coloration eyes, on palate, oral mucosa presenting complaints time admission. All radiographic imaging, including computed tomography (CT), paranasal sinuses (PNS), brain magnetic resonance imaging (MRI) carried out which confirmed mucosal thickening adjacent sinus bony erosions intracranial extension. treated local debridement infected necrotic tissue along intravenous liposomal Amphotericin B Posaconazole depending case. Due timely management, six prognosis was good due diagnosis treatment, while patient severe illness deteriorated died. misuse other can lead ROCM, further increase risk developing mortality. It is stressed that only recommended therapeutic advice should be followed self-isolation avoid unnecessary use corticosteroids. This also emphasizes need more vigilant monitoring high suspicion treatment invasive infection. Early management reduce morbidity

Language: Английский

Could cattle dung burning have contributed to the epidemic of COVID‐19‐associated mucormycosis in India? Results of an experimental aero‐mycological study DOI Open Access
Soundappan Kathirvel, Valliappan Muthu, Shivaprakash M. Rudramurthy

et al.

Mycoses, Journal Year: 2022, Volume and Issue: 65(11), P. 1024 - 1029

Published: June 21, 2022

Several hypotheses have been proposed for explaining the outbreak of coronavirus disease 2019 (COVID-19)-associated mucormycosis in India, including burning cattle dung cakes, though no study has yet conducted to support this claim.We an aero-mycological evaluate whether Mucorales air increased during or after cakes. We further compared growth indoor samples from houses with and without cattle. also cultured fresh dried soil Mucorales.We noted significant difference proportion growing (4/22 [18.2%]) (3/2 [13.6%]) than that collected immediately before [18.2%]). were isolated 15.4% obtained different (both rural urban); was not significantly households observed 6 8 [75%] 3 [50%] samples. The most common Lichtheimia corymbifera, while Rhizopus arrhizus species samples.We found increase cake before. It seems unlikely contributes occurrence mucormycosis.

Language: Английский

Citations

11
Serum glucose-regulated protein 78 (GRP78) levels in COVID-19-associated mucormycosis: results of a case–control study DOI Open Access
Valliappan Muthu, Manpreet Dhaliwal, Arunima Sharma

et al.

Mycopathologia, Journal Year: 2022, Volume and Issue: 187(4), P. 355 - 362

Published: June 21, 2022

Language: Английский

Citations

10
Alternating pattern of rhino-orbital–cerebral mucormycosis with COVID-19 in diabetic patients DOI Open Access
Çağlar Eker, Özgür Tarkan, Özgür Sürmelioğlu

et al.

European Archives of Oto-Rhino-Laryngology, Journal Year: 2022, Volume and Issue: 280(1), P. 219 - 226

Published: June 29, 2022

Language: Английский

Citations

10
Virulence traits and novel drug delivery strategies for mucormycosis post-COVID-19: a comprehensive review DOI Creative Commons
Md. Faiyazuddin, Anggun Sophia, Sumel Ashique

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 25, 2023

The outbreak of a fatal black fungus infection after the resurgence cadaverous COVID-19 has exhorted scientists worldwide to develop nutshell by repurposing or designing new formulations address crisis. Patients expressing are more susceptible Mucormycosis (MCR) and thus fall easy prey decease accounting for this global threat. Their mortality rates range around 32-70% depending on organs affected grow even higher despite treatment. many contemporary recommendations strongly advise using liposomal amphotericin B surgery as first-line therapy whenever practicable. MCR is dangerous that requires an antifungal drug administration appropriate prescription, typically one following: Amphotericin B, Posaconazole, Isavuconazole since fungi cause resistant other medications like fluconazole, voriconazole, echinocandins. Posaconazole administered through veins (intravenously), isavuconazole mouth (orally). From last several years so compounds developed against invasive fungal disease but only few them able induce effective treatment micorals. Adjuvant medicines, particularly, difficult assess without prospective randomized controlled investigations, which challenging conduct given lower incidence from Mucormycosis. present analysis provides insight into pathogenesis, epidemiology, clinical manifestations, underlying virulence, growth mechanisms. In addition, current in Post Covid-19 individuals includes conventional novel nano-based advanced management systems procuring deadly infection. study urges involving nanomedicine prevent at commencement infection, delay progression, mitigate fatality risk.

Language: Английский

Citations

6
Unnecessary Use of Corticosteroids for managing early mild symptoms of COVID-19 may lead to Rhino-ortibal-cerebral mucormycosis in Patients with Diabetes – a case series from Lahore, Pakistan DOI Creative Commons
Somia Iqtadar,

Masooma Hashmat,

Muhammad Nabeel Akbar Chaudhry

et al.

Therapeutic Advances in Infectious Disease, Journal Year: 2022, Volume and Issue: 9, P. 204993612210974 - 204993612210974

Published: Jan. 1, 2022

Rhino-orbital-cerebral mucormycosis (ROCM), a rare but fatal fungal infection, has recently emerged as serious complication after corticosteroids therapy in COVID-19 patients, predominantly diabetic and immunocompromised patients. The World Health Organization (WHO) current guidelines recommend administration hospitalized patients requiring supplementary oxygen or mechanical ventilation. Herein, we report case series of seven with COVID-19; three mild, moderate, one severe, from Lahore, Pakistan; all were using for managing their early mild symptoms at home around 2–3 weeks without physician’s advise, presented, admitted ROCM to Mayo hospital, March June 2021. Out the five had uncontrolled diabetes mellitus (DM) comorbidity. Eye pain, facial swelling nasal blockage, black coloration eyes, on palate, oral mucosa presenting complaints time admission. All radiographic imaging, including computed tomography (CT), paranasal sinuses (PNS), brain magnetic resonance imaging (MRI) carried out which confirmed mucosal thickening adjacent sinus bony erosions intracranial extension. treated local debridement infected necrotic tissue along intravenous liposomal Amphotericin B Posaconazole depending case. Due timely management, six prognosis was good due diagnosis treatment, while patient severe illness deteriorated died. misuse other can lead ROCM, further increase risk developing mortality. It is stressed that only recommended therapeutic advice should be followed self-isolation avoid unnecessary use corticosteroids. This also emphasizes need more vigilant monitoring high suspicion treatment invasive infection. Early management reduce morbidity

Language: Английский

Citations

9