Multicenter Case–Control Study of COVID-19–Associated Mucormycosis Outbreak, India

Emerging infectious diseases, Journal Year: 2023, Volume and Issue: 29(1), P. 8 - 19

Published: Jan. 1, 2023

Abstract We performed a case–control study across 25 hospitals in India for the period of January–June 2021 to evaluate reasons an COVID-19–associated mucormycosis (CAM) outbreak. investigated whether COVID-19 treatment practices (glucocorticoids, zinc, tocilizumab, and others) were associated with CAM. included 1,733 cases CAM 3,911 age-matched controls. found cumulative glucocorticoid dose (odds ratio [OR] 1.006, 95% CI 1.004–1.007) zinc supplementation (OR 2.76, 2.24–3.40), along elevated C-reactive protein 1.004, 1.002–1.006), host factors (renal transplantation [OR 7.58, 3.31–17.40], diabetes mellitus 6.72, 5.45–8.28], diabetic ketoacidosis during 4.41, 2.03–9.60]), rural residence 2.88, 2.12–3.79), significantly Mortality rate at 12 weeks was 32.2% (473/1,471). emphasize judicious use therapies optimal glycemic control prevent

Language: Английский

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Risk factors, mortality, and predictors of survival in COVID-19-associated pulmonary mucormycosis: a multicentre retrospective study from India

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 30(3), P. 368 - 374

Published: Dec. 9, 2023

Language: Английский

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Epidemiology of COVID-19–Associated Mucormycosis

Current Fungal Infection Reports, Journal Year: 2023, Volume and Issue: 17(2), P. 156 - 175

Published: May 3, 2023

Language: Английский

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Risk factors for pulmonary mucormycosis in subjects with diabetes mellitus—A case‐control study

Mycoses, Journal Year: 2023, Volume and Issue: 66(9), P. 787 - 794

Published: May 16, 2023

Abstract Background Factors associated with pulmonary mucormycosis (PM) among subjects diabetes mellitus (DM) remain unclear. Following the coronavirus disease (COVID‐19)‐associated outbreak in India, specific environmental exposures (especially cattle dung exposure) were proposed as possible aetiology. We hypothesized that factors are PM. compared DM (cases) and without PM (controls). Methods In this case‐control study, for each case, we included five unmatched diabetic controls (hospital [ n = 2], community 3]) collected information on demography, COVID‐19 infection, glycated haemoglobin% (HbA1c), type of house (pucca vs. kutcha) where participants reside, other factors. The primary exposure tested was (CDE; using cakes fuel or handling). performed a multivariate logistic regression to explore report association an adjusted odds ratio (OR) 95% confidence intervals (CI). Results enrolled 39 cases 199 80], 119]). CDE (OR 0.68, CI [0.14‐3.31]; p 0.63) not increased DM. found male sex 4.07, [1.16‐14.31]), higher HbA1c 1.51, [1.18‐16.32]), 28.25, [7.02‐113.6]) residence at kutcha 4.84, [1.33‐17.52]) Conclusion Cattle Instead, sex, poor glycaemic control, housing mucormycosis.

Language: Английский

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COVID-19, mucormycosis, and the cow: Damned lies!

Indian Journal of Medical Microbiology, Journal Year: 2023, Volume and Issue: 44, P. 100382 - 100382

Published: May 24, 2023

Language: Английский

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Association of COVID with Mycosis in General

Infectious Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 24(6)

Published: Jan. 22, 2024

Background: The COVID-19 pandemic caused by SARS-CoV-2 is a respiratory disease which created havoc worldwide, was accompanied another peculiar, otherwise rare, secondary fungal infection Mucormycosis observed at exceptionally high incidence in India during the second wave of COVID-19. article explores possible links between two infectious diseases to understand higher-than-normal occurrence patients. Coronavirus enters patients through ACE-2 and many other receptors like- NRP-1, TfR, CD-126, CD-26. Virus bind cells possessing these affect their proper functioning, disturbing homeostatic metabolism resulting conditions like hyperglycemia, Diabetic Ketoacidosis (DKA), low serum pH, iron overload, anemia, hypoxia, immunosuppression as explained article. All outcomes provide very supportive environment for attack spread fungi. major receptor humans GRP-78. Its expression upregulated coronavirus entry hyperferritinemia, acidic prevalent COVID patients, thus providing an easy species. Upregulation GRP-78 furthermore damages pancreatic β-cells intensifies showing quite synergic relationship. Inordinate rise cases might be facts large proportion diabetic emergence deadly strain coronavirus- Delta strain, higher doses steroids antibodies used treat against this overburdened health care services, sudden much need oxygen supply use industrial could explain outbreak Objective: present review discusses functional interdependence summarizes Mucormycosis. Conclusion: metabolic pathways affected result severe physiological conditions- DKA, immunosuppression, hypoxia. not only increase GRP-78, fungi but also play crucial role quality media fungus establish grow. Hence explains epidemic India.

Language: Английский

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Pathogenesis of COVID-19-Associated Mucormycosis: An Updated Evidence-Based Review

Current Fungal Infection Reports, Journal Year: 2024, Volume and Issue: 18(1), P. 69 - 75

Published: Feb. 1, 2024

Language: Английский

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Aspergillus sensitization in non-smokers versus smokers with chronic obstructive pulmonary disease

Lung India, Journal Year: 2024, Volume and Issue: 41(5), P. 387 - 391

Published: Aug. 31, 2024

Language: Английский

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Non-Aspergillus Pulmonary Mold Infections

Published: Jan. 1, 2024

Language: Английский

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Re: “COVID-19, mucormycosis, and the cow: Damned lies!”

Indian Journal of Medical Microbiology, Journal Year: 2023, Volume and Issue: 46, P. 100462 - 100462

Published: Sept. 1, 2023

Language: Английский

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